Wnt canonical signaling pathway
Wnt canonical signaling pathway. A. When the wnt signaling pathway is not active, β-catenin is bound to the degradation complex composed by APC, axin, and the serine/theronine kinases CK1 and GSK3. The main role of the degradation complex is to phosphorylate β-catenin leading to its degradation by means of the proteasome-ubiquitin pathway. There are several negative regulators that operate at the receptor-ligand level; such as, Cer1, DKK, WIF1 and sFRP, whose function is to modulate positive signals induced by Wnts. B. The contact of wnt with its receptors leads to the stabilization of β-catenin and its accumulation in cytoplasm and nucleus. β-catenin displaces the transcriptional repressor groucho from the LEF/TCF complex, leading to the activation of target genes, such as c-myc and cyclinD1, which are involved in cell proliferation and cell cycle progression.

Publication
Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway. (2008) Carlos Perez-Plasencia, et al. Int Arch Med. 2008;1:10-10. Figure: F2.Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
---|---|---|---|---|---|---|
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT1 | 7471 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT2 | 7472 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT2B | 7482 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT3 | 7473 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT3A | 89780 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT4 | 54361 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT6 | 7475 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT7A | 7476 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT7B | 7477 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT8A | 7478 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT8B | 7479 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT9A | 7483 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT9B | 7484 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT10A | 80326 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT10B | 7480 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT11 | 7481 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT16 | 51384 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT5A | 7474 |
Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT5B | 81029 |
Homo sapiens | Primates | Cer1 | CER1 | ncbigene_symbol | CER1 | 9350 |
Homo sapiens | Primates | Cer1 | CER1 | ncbigene_synonym | C3CER1 | 23739 |
Homo sapiens | Primates | WIF1 | WIF1 | ncbigene_symbol | WIF1 | 11197 |
Homo sapiens | Primates | LRP | LRP | ncbigene_synonym | RPSA | 3921 |
Homo sapiens | Primates | LRP | LRP | ncbigene_synonym | LRP1 | 4035 |
Homo sapiens | Primates | LRP | LRP | ncbigene_synonym | PTPRA | 5786 |
Homo sapiens | Primates | LRP | LRP | ncbigene_synonym | MVP | 9961 |
Homo sapiens | Primates | GSK3 | GSK3 | famplex_relations | GSK3A | 2931 |
Homo sapiens | Primates | GSK3 | GSK3 | famplex_relations | GSK3B | 2932 |
Homo sapiens | Primates | Dvl | DVL | ncbigene_synonym | DVL1 | 1855 |
Homo sapiens | Primates | Dvl | DVL | ncbigene_synonym | DVL1P1 | 8215 |
Homo sapiens | Primates | Dvl | DVL | famplex_relations | DVL2 | 1856 |
Homo sapiens | Primates | Dvl | DVL | famplex_relations | DVL3 | 1857 |
Homo sapiens | Primates | Dvl | DV1 | ncbigene_synonym | IFT81 | 28981 |
Homo sapiens | Primates | APC | APC | ncbigene_symbol | APC | 324 |
Homo sapiens | Primates | APC | APC | ncbigene_synonym | PROC | 5624 |
Homo sapiens | Primates | CK1 | CK1 | ncbigene_synonym | CSNK1A1 | 1452 |
Homo sapiens | Primates | CK1 | CK1 | ncbigene_synonym | KRT1 | 3848 |
Homo sapiens | Primates | CK1 | CK1 | ncbigene_synonym | CSNK1A1L | 122011 |
Homo sapiens | Primates | Axin | AXIN | ncbigene_synonym | AXIN1 | 8312 |
Homo sapiens | Primates | Axin | AXIN | famplex_relations | AXIN2 | 8313 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMA1 | 5682 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMA2 | 5683 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMA3 | 5684 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMA4 | 5685 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMA5 | 5686 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMA6 | 5687 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMA7 | 5688 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMA8 | 143471 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMB1 | 5689 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMB10 | 5699 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMB2 | 5690 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMB3 | 5691 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMB4 | 5692 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMB5 | 5693 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMB6 | 5694 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMB7 | 5695 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMB8 | 5696 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMB9 | 5698 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMC1 | 5700 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMC2 | 5701 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMC3 | 5702 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMC4 | 5704 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMC5 | 5705 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMC6 | 5706 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMD1 | 5707 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMD10 | 5716 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMD11 | 5717 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMD12 | 5718 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMD13 | 5719 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMD14 | 10213 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMD2 | 5708 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMD3 | 5709 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMD4 | 5710 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMD5 | 5711 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMD6 | 9861 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMD7 | 5713 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMD8 | 5714 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMD9 | 5715 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSME1 | 5720 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSME2 | 5721 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSME3 | 10197 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | PSMF1 | 9491 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | SEM1 | 7979 |
Homo sapiens | Primates | Proteasome | PROTEASOME | famplex_relations | USP5 | 8078 |
Homo sapiens | Primates | TCF | TCF | ncbigene_synonym | HNF4A | 3172 |
Homo sapiens | Primates | HDAC | HDAC | ncbigene_synonym | HDAC9 | 9734 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | HDAC1 | 3065 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | HDAC2 | 3066 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | HDAC3 | 8841 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | HDAC8 | 55869 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | HDAC4 | 9759 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | HDAC5 | 10014 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | HDAC7 | 51564 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | HDAC6 | 10013 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | HDAC10 | 83933 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | SIRT1 | 23411 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | SIRT2 | 22933 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | SIRT3 | 23410 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | SIRT4 | 23409 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | SIRT5 | 23408 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | SIRT6 | 51548 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | SIRT7 | 51547 |
Homo sapiens | Primates | HDAC | HDAC | famplex_relations | HDAC11 | 79885 |
Homo sapiens | Primates | myc | MYC | ncbigene_symbol | MYC | 4609 |
Homo sapiens | Primates | cyclinD | CYCLIND | famplex_relations | CCND1 | 595 |
Homo sapiens | Primates | cyclinD | CYCLIND | famplex_relations | CCND2 | 894 |
Homo sapiens | Primates | cyclinD | CYCLIND | famplex_relations | CCND3 | 896 |
Homo sapiens | Primates | jún | JUN | ncbigene_symbol | JUN | 3725 |
Homo sapiens | Primates | jún | JUN | famplex_relations | JUNB | 3726 |
Homo sapiens | Primates | jún | JUN | famplex_relations | JUND | 3727 |
Homo sapiens | Primates | MMP7 | MMP7 | ncbigene_symbol | MMP7 | 4316 |
Mus musculus | Rodents | Cer1 | CER1 | ncbigene_symbol | Cer1 | 12622 |
Mus musculus | Rodents | Cer1 | CER1 | ncbigene_synonym | Acer1 | 171168 |
Mus musculus | Rodents | WIF1 | WIF1 | ncbigene_symbol | Wif1 | 24117 |
Mus musculus | Rodents | LRP | LRP | ncbigene_synonym | Lrp1 | 16971 |
Mus musculus | Rodents | LRP | LRP | ncbigene_synonym | Mvp | 78388 |
Mus musculus | Rodents | LRP | LRP | ncbigene_synonym | Txlng | 353170 |
Mus musculus | Rodents | GSK3 | GSK3 | ncbigene_synonym | Gsk3b | 56637 |
Mus musculus | Rodents | Dvl | DVL | ncbigene_synonym | Dvl1 | 13542 |
Mus musculus | Rodents | APC | APC | ncbigene_symbol | Apc | 11789 |
Mus musculus | Rodents | CK1 | CK1 | ncbigene_synonym | Gm12892 | 666937 |
Mus musculus | Rodents | Axin | AXIN | ncbigene_synonym | Axin1 | 12005 |
Mus musculus | Rodents | myc | MYC | ncbigene_symbol | Myc | 17869 |
Mus musculus | Rodents | myc | MYC | ncbigene_synonym | Nol3 | 78688 |
Mus musculus | Rodents | jún | JUN | ncbigene_symbol | Jun | 16476 |
Mus musculus | Rodents | MMP7 | MMP7 | ncbigene_symbol | Mmp7 | 17393 |
Drosophila melanogaster | Invertebrates | WNT | WNT | ncbigene_synonym | Wnt5 | 32838 |
Drosophila melanogaster | Invertebrates | WNT | WNT | ncbigene_synonym | Wnt4 | 34007 |
Drosophila melanogaster | Invertebrates | WNT | WNT | ncbigene_synonym | wg | 34009 |
Drosophila melanogaster | Invertebrates | WNT | WNT | ncbigene_synonym | Wnt2 | 35975 |
Drosophila melanogaster | Invertebrates | LRP | LRP | ncbigene_synonym | arr | 44279 |
Drosophila melanogaster | Invertebrates | Fz | FZ | ncbigene_symbol | fz | 45307 |
Drosophila melanogaster | Invertebrates | GSK3 | GSK3 | ncbigene_synonym | sgg | 31248 |
Drosophila melanogaster | Invertebrates | Dvl | DVL | ncbigene_synonym | dsh | 32078 |
Drosophila melanogaster | Invertebrates | PPp | PPP | ncbigene_synonym | amon | 43215 |
Drosophila melanogaster | Invertebrates | APC | APC | ncbigene_symbol | Apc | 44642 |
Drosophila melanogaster | Invertebrates | APC | APC | ncbigene_synonym | Apc2 | 42871 |
Drosophila melanogaster | Invertebrates | APC | APC | ncbigene_synonym | Axn | 43565 |
Drosophila melanogaster | Invertebrates | APC | APC | ncbigene_synonym | Fs(3)Apc | 49116 |
Drosophila melanogaster | Invertebrates | Bcat | BCAT | ncbigene_synonym | arm | 31151 |
Drosophila melanogaster | Invertebrates | Bcat | BCAT | ncbigene_synonym | CG1673 | 32297 |
Drosophila melanogaster | Invertebrates | CK1 | CK1 | ncbigene_synonym | CkIalpha | 32221 |
Drosophila melanogaster | Invertebrates | CK1 | CK1 | ncbigene_synonym | gish | 49701 |
Drosophila melanogaster | Invertebrates | Pygo | PYGO | ncbigene_symbol | pygo | 43718 |
Drosophila melanogaster | Invertebrates | Groucho | GROUCHO | ncbigene_synonym | gro | 43162 |
Drosophila melanogaster | Invertebrates | TCF | TCF | ncbigene_synonym | pan | 43769 |
Drosophila melanogaster | Invertebrates | HDAC | HDAC | ncbigene_synonym | HDAC4 | 32278 |
Drosophila melanogaster | Invertebrates | HDAC | HDAC | ncbigene_synonym | HDAC6 | 32461 |
Drosophila melanogaster | Invertebrates | HDAC | HDAC | ncbigene_synonym | HDAC1 | 38565 |
Drosophila melanogaster | Invertebrates | HDAC | HDAC | ncbigene_synonym | HDAC3 | 44446 |
Drosophila melanogaster | Invertebrates | myc | MYC | ncbigene_symbol | Myc | 31310 |
Drosophila melanogaster | Invertebrates | cyclinD | CYCLIND | ncbigene_synonym | CycD | 32551 |
Drosophila melanogaster | Invertebrates | jún | JUN | ncbigene_synonym | Jra | 36057 |
Drosophila melanogaster | Invertebrates | EN | EN | ncbigene_symbol | en | 36240 |
Danio rerio | Vertebrates | WIF1 | WIF1 | ncbigene_symbol | wif1 | 30476 |
Danio rerio | Vertebrates | SFRP | SFRP | ncbigene_synonym | szl | 353294 |
Danio rerio | Vertebrates | SFRP | SFRP | ncbigene_synonym | tlc | 386615 |
Danio rerio | Vertebrates | LRP | LRP | ncbigene_synonym | cby1 | 326875 |
Danio rerio | Vertebrates | Krm | KRM | ncbigene_synonym | kremen1 | 100141352 |
Danio rerio | Vertebrates | GSK3 | GSK3 | ncbigene_synonym | gsk3ba | 30654 |
Danio rerio | Vertebrates | GSK3 | GSK3 | ncbigene_synonym | gsk3ab | 30664 |
Danio rerio | Vertebrates | APC | APC | ncbigene_symbol | apc | 386762 |
Danio rerio | Vertebrates | TCF | TCF | ncbigene_synonym | elk4 | 30093 |
Danio rerio | Vertebrates | myc | MYC | ncbigene_synonym | myca | 30686 |
Danio rerio | Vertebrates | myc | MYC | ncbigene_synonym | mycbp2 | 368439 |
Danio rerio | Vertebrates | jún | JUN | ncbigene_symbol | jun | 335916 |
Word | Match | MeSH | Name | ChEBI |
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Disease mentions
Word | Match | MeSH | Name | DOID |
---|---|---|---|---|
Cancer | NA |