Wnt canonical signaling pathway

Wnt canonical signaling pathway. A. When the wnt signaling pathway is not active, β-catenin is bound to the degradation complex composed by APC, axin, and the serine/theronine kinases CK1 and GSK3. The main role of the degradation complex is to phosphorylate β-catenin leading to its degradation by means of the proteasome-ubiquitin pathway. There are several negative regulators that operate at the receptor-ligand level; such as, Cer1, DKK, WIF1 and sFRP, whose function is to modulate positive signals induced by Wnts. B. The contact of wnt with its receptors leads to the stabilization of β-catenin and its accumulation in cytoplasm and nucleus. β-catenin displaces the transcriptional repressor groucho from the LEF/TCF complex, leading to the activation of target genes, such as c-myc and cyclinD1, which are involved in cell proliferation and cell cycle progression.
Wnt canonical signaling pathway

Publication

Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway. (2008) Carlos Perez-Plasencia, et al. Int Arch Med. 2008;1:10-10. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates WNT WNT famplex_relations WNT1 7471
Homo sapiens Primates WNT WNT famplex_relations WNT2 7472
Homo sapiens Primates WNT WNT famplex_relations WNT2B 7482
Homo sapiens Primates WNT WNT famplex_relations WNT3 7473
Homo sapiens Primates WNT WNT famplex_relations WNT3A 89780
Homo sapiens Primates WNT WNT famplex_relations WNT4 54361
Homo sapiens Primates WNT WNT famplex_relations WNT6 7475
Homo sapiens Primates WNT WNT famplex_relations WNT7A 7476
Homo sapiens Primates WNT WNT famplex_relations WNT7B 7477
Homo sapiens Primates WNT WNT famplex_relations WNT8A 7478
Homo sapiens Primates WNT WNT famplex_relations WNT8B 7479
Homo sapiens Primates WNT WNT famplex_relations WNT9A 7483
Homo sapiens Primates WNT WNT famplex_relations WNT9B 7484
Homo sapiens Primates WNT WNT famplex_relations WNT10A 80326
Homo sapiens Primates WNT WNT famplex_relations WNT10B 7480
Homo sapiens Primates WNT WNT famplex_relations WNT11 7481
Homo sapiens Primates WNT WNT famplex_relations WNT16 51384
Homo sapiens Primates WNT WNT famplex_relations WNT5A 7474
Homo sapiens Primates WNT WNT famplex_relations WNT5B 81029
Homo sapiens Primates Cer1 CER1 ncbigene_symbol CER1 9350
Homo sapiens Primates Cer1 CER1 ncbigene_synonym C3CER1 23739
Homo sapiens Primates WIF1 WIF1 ncbigene_symbol WIF1 11197
Homo sapiens Primates LRP LRP ncbigene_synonym RPSA 3921
Homo sapiens Primates LRP LRP ncbigene_synonym LRP1 4035
Homo sapiens Primates LRP LRP ncbigene_synonym PTPRA 5786
Homo sapiens Primates LRP LRP ncbigene_synonym MVP 9961
Homo sapiens Primates GSK3 GSK3 famplex_relations GSK3A 2931
Homo sapiens Primates GSK3 GSK3 famplex_relations GSK3B 2932
Homo sapiens Primates Dvl DVL ncbigene_synonym DVL1 1855
Homo sapiens Primates Dvl DVL ncbigene_synonym DVL1P1 8215
Homo sapiens Primates Dvl DVL famplex_relations DVL2 1856
Homo sapiens Primates Dvl DVL famplex_relations DVL3 1857
Homo sapiens Primates Dvl DV1 ncbigene_synonym IFT81 28981
Homo sapiens Primates APC APC ncbigene_symbol APC 324
Homo sapiens Primates APC APC ncbigene_synonym PROC 5624
Homo sapiens Primates CK1 CK1 ncbigene_synonym CSNK1A1 1452
Homo sapiens Primates CK1 CK1 ncbigene_synonym KRT1 3848
Homo sapiens Primates CK1 CK1 ncbigene_synonym CSNK1A1L 122011
Homo sapiens Primates Axin AXIN ncbigene_synonym AXIN1 8312
Homo sapiens Primates Axin AXIN famplex_relations AXIN2 8313
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA1 5682
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA2 5683
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA3 5684
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA4 5685
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA5 5686
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA6 5687
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA7 5688
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA8 143471
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB1 5689
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB10 5699
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB2 5690
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB3 5691
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB4 5692
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB5 5693
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB6 5694
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB7 5695
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB8 5696
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB9 5698
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC1 5700
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC2 5701
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC3 5702
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC4 5704
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC5 5705
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC6 5706
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD1 5707
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD10 5716
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD11 5717
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD12 5718
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD13 5719
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD14 10213
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD2 5708
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD3 5709
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD4 5710
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD5 5711
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD6 9861
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD7 5713
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD8 5714
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD9 5715
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSME1 5720
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSME2 5721
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSME3 10197
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMF1 9491
Homo sapiens Primates Proteasome PROTEASOME famplex_relations SEM1 7979
Homo sapiens Primates Proteasome PROTEASOME famplex_relations USP5 8078
Homo sapiens Primates TCF TCF ncbigene_synonym HNF4A 3172
Homo sapiens Primates HDAC HDAC ncbigene_synonym HDAC9 9734
Homo sapiens Primates HDAC HDAC famplex_relations HDAC1 3065
Homo sapiens Primates HDAC HDAC famplex_relations HDAC2 3066
Homo sapiens Primates HDAC HDAC famplex_relations HDAC3 8841
Homo sapiens Primates HDAC HDAC famplex_relations HDAC8 55869
Homo sapiens Primates HDAC HDAC famplex_relations HDAC4 9759
Homo sapiens Primates HDAC HDAC famplex_relations HDAC5 10014
Homo sapiens Primates HDAC HDAC famplex_relations HDAC7 51564
Homo sapiens Primates HDAC HDAC famplex_relations HDAC6 10013
Homo sapiens Primates HDAC HDAC famplex_relations HDAC10 83933
Homo sapiens Primates HDAC HDAC famplex_relations SIRT1 23411
Homo sapiens Primates HDAC HDAC famplex_relations SIRT2 22933
Homo sapiens Primates HDAC HDAC famplex_relations SIRT3 23410
Homo sapiens Primates HDAC HDAC famplex_relations SIRT4 23409
Homo sapiens Primates HDAC HDAC famplex_relations SIRT5 23408
Homo sapiens Primates HDAC HDAC famplex_relations SIRT6 51548
Homo sapiens Primates HDAC HDAC famplex_relations SIRT7 51547
Homo sapiens Primates HDAC HDAC famplex_relations HDAC11 79885
Homo sapiens Primates myc MYC ncbigene_symbol MYC 4609
Homo sapiens Primates cyclinD CYCLIND famplex_relations CCND1 595
Homo sapiens Primates cyclinD CYCLIND famplex_relations CCND2 894
Homo sapiens Primates cyclinD CYCLIND famplex_relations CCND3 896
Homo sapiens Primates jún JUN ncbigene_symbol JUN 3725
Homo sapiens Primates jún JUN famplex_relations JUNB 3726
Homo sapiens Primates jún JUN famplex_relations JUND 3727
Homo sapiens Primates MMP7 MMP7 ncbigene_symbol MMP7 4316
Mus musculus Rodents Cer1 CER1 ncbigene_symbol Cer1 12622
Mus musculus Rodents Cer1 CER1 ncbigene_synonym Acer1 171168
Mus musculus Rodents WIF1 WIF1 ncbigene_symbol Wif1 24117
Mus musculus Rodents LRP LRP ncbigene_synonym Lrp1 16971
Mus musculus Rodents LRP LRP ncbigene_synonym Mvp 78388
Mus musculus Rodents LRP LRP ncbigene_synonym Txlng 353170
Mus musculus Rodents GSK3 GSK3 ncbigene_synonym Gsk3b 56637
Mus musculus Rodents Dvl DVL ncbigene_synonym Dvl1 13542
Mus musculus Rodents APC APC ncbigene_symbol Apc 11789
Mus musculus Rodents CK1 CK1 ncbigene_synonym Gm12892 666937
Mus musculus Rodents Axin AXIN ncbigene_synonym Axin1 12005
Mus musculus Rodents myc MYC ncbigene_symbol Myc 17869
Mus musculus Rodents myc MYC ncbigene_synonym Nol3 78688
Mus musculus Rodents jún JUN ncbigene_symbol Jun 16476
Mus musculus Rodents MMP7 MMP7 ncbigene_symbol Mmp7 17393
Drosophila melanogaster Invertebrates WNT WNT ncbigene_synonym Wnt5 32838
Drosophila melanogaster Invertebrates WNT WNT ncbigene_synonym Wnt4 34007
Drosophila melanogaster Invertebrates WNT WNT ncbigene_synonym wg 34009
Drosophila melanogaster Invertebrates WNT WNT ncbigene_synonym Wnt2 35975
Drosophila melanogaster Invertebrates LRP LRP ncbigene_synonym arr 44279
Drosophila melanogaster Invertebrates Fz FZ ncbigene_symbol fz 45307
Drosophila melanogaster Invertebrates GSK3 GSK3 ncbigene_synonym sgg 31248
Drosophila melanogaster Invertebrates Dvl DVL ncbigene_synonym dsh 32078
Drosophila melanogaster Invertebrates PPp PPP ncbigene_synonym amon 43215
Drosophila melanogaster Invertebrates APC APC ncbigene_symbol Apc 44642
Drosophila melanogaster Invertebrates APC APC ncbigene_synonym Apc2 42871
Drosophila melanogaster Invertebrates APC APC ncbigene_synonym Axn 43565
Drosophila melanogaster Invertebrates APC APC ncbigene_synonym Fs(3)Apc 49116
Drosophila melanogaster Invertebrates Bcat BCAT ncbigene_synonym arm 31151
Drosophila melanogaster Invertebrates Bcat BCAT ncbigene_synonym CG1673 32297
Drosophila melanogaster Invertebrates CK1 CK1 ncbigene_synonym CkIalpha 32221
Drosophila melanogaster Invertebrates CK1 CK1 ncbigene_synonym gish 49701
Drosophila melanogaster Invertebrates Pygo PYGO ncbigene_symbol pygo 43718
Drosophila melanogaster Invertebrates Groucho GROUCHO ncbigene_synonym gro 43162
Drosophila melanogaster Invertebrates TCF TCF ncbigene_synonym pan 43769
Drosophila melanogaster Invertebrates HDAC HDAC ncbigene_synonym HDAC4 32278
Drosophila melanogaster Invertebrates HDAC HDAC ncbigene_synonym HDAC6 32461
Drosophila melanogaster Invertebrates HDAC HDAC ncbigene_synonym HDAC1 38565
Drosophila melanogaster Invertebrates HDAC HDAC ncbigene_synonym HDAC3 44446
Drosophila melanogaster Invertebrates myc MYC ncbigene_symbol Myc 31310
Drosophila melanogaster Invertebrates cyclinD CYCLIND ncbigene_synonym CycD 32551
Drosophila melanogaster Invertebrates jún JUN ncbigene_synonym Jra 36057
Drosophila melanogaster Invertebrates EN EN ncbigene_symbol en 36240
Danio rerio Vertebrates WIF1 WIF1 ncbigene_symbol wif1 30476
Danio rerio Vertebrates SFRP SFRP ncbigene_synonym szl 353294
Danio rerio Vertebrates SFRP SFRP ncbigene_synonym tlc 386615
Danio rerio Vertebrates LRP LRP ncbigene_synonym cby1 326875
Danio rerio Vertebrates Krm KRM ncbigene_synonym kremen1 100141352
Danio rerio Vertebrates GSK3 GSK3 ncbigene_synonym gsk3ba 30654
Danio rerio Vertebrates GSK3 GSK3 ncbigene_synonym gsk3ab 30664
Danio rerio Vertebrates APC APC ncbigene_symbol apc 386762
Danio rerio Vertebrates TCF TCF ncbigene_synonym elk4 30093
Danio rerio Vertebrates myc MYC ncbigene_synonym myca 30686
Danio rerio Vertebrates myc MYC ncbigene_synonym mycbp2 368439
Danio rerio Vertebrates jún JUN ncbigene_symbol jun 335916

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA