Regulation of NFKB pathway by PPAR agonists in CNS diseases

Regulation of NF-κB pathway by PPAR agonists in CNS diseases. The activation of microglia, macrophage and dendritic cells through toll-like receptor, CD40 or cytokine associated NF-κB pathway leads to secretion of inflammatory cytokines leading to pathogenesis of CNS diseases. PPAR agonists inhibit NF-κB pathway resulting in inhibition of CNS diseases.
Regulation of NFKB pathway by PPAR agonists in CNS diseases
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Publication

PPAR Regulation of Inflammatory Signaling in CNS Diseases. (2008) John J. Bright, et al. PPAR Res. 2008;2008:658520. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Rattus norvegicus Rodents PPAR PPAR ncbigene_synonym Ppara 25747
Rattus norvegicus Rodents IL-12 IL12 ncbigene_synonym Il12b 64546
Rattus norvegicus Rodents LBP LBP ncbigene_symbol Lbp 29469
Rattus norvegicus Rodents LBP LBP ncbigene_synonym Ehhadh 171142
Rattus norvegicus Rodents CD40L CD40L ncbigene_synonym Cd40lg 84349
Rattus norvegicus Rodents CD14 CD14 ncbigene_symbol Cd14 60350
Rattus norvegicus Rodents MD2 MD2 ncbigene_synonym Ly96 448830
Rattus norvegicus Rodents CD40 CD40 ncbigene_symbol Cd40 171369
Rattus norvegicus Rodents TLR4 TLR4 ncbigene_symbol Tlr4 29260
Rattus norvegicus Rodents TLR9 TLR9 ncbigene_symbol Tlr9 338457
Rattus norvegicus Rodents MyD88 MYD88 ncbigene_symbol Myd88 301059
Rattus norvegicus Rodents TRIF TRIF ncbigene_synonym Rnf138 94196
Rattus norvegicus Rodents TRAF6 TRAF6 ncbigene_symbol Traf6 311245
Rattus norvegicus Rodents p65 P65 ncbigene_synonym Syt1 25716
Rattus norvegicus Rodents IL-27 IL27 ncbigene_symbol Il27 365368
Homo sapiens Primates PPAR PPAR ncbigene_synonym PPARA 5465
Homo sapiens Primates PPAR PPAR famplex_relations PPARD 5467
Homo sapiens Primates PPAR PPAR famplex_relations PPARG 5468
Homo sapiens Primates IL-12 IL12 famplex_relations IL12A 3592
Homo sapiens Primates IL-12 IL12 famplex_relations IL12B 3593
Homo sapiens Primates LPS LPS ncbigene_synonym IRF6 3664
Homo sapiens Primates LBP LBP ncbigene_symbol LBP 3929
Homo sapiens Primates LBP LBP ncbigene_synonym EHHADH 1962
Homo sapiens Primates LBP LBP ncbigene_synonym RPSA 3921
Homo sapiens Primates CD40L CD40L ncbigene_synonym CD40LG 959
Homo sapiens Primates CD14 CD14 ncbigene_symbol CD14 929
Homo sapiens Primates CD14 CD14 ncbigene_synonym NDUFA2 4695
Homo sapiens Primates MD2 MD2 ncbigene_synonym LY96 23643
Homo sapiens Primates CD40 CD40 ncbigene_symbol CD40 958
Homo sapiens Primates TLR4 TLR4 ncbigene_symbol TLR4 7099
Homo sapiens Primates TLR9 TLR9 ncbigene_symbol TLR9 54106
Homo sapiens Primates MyD88 MYD88 ncbigene_symbol MYD88 4615
Homo sapiens Primates TRIF TRIF ncbigene_synonym TRIM69 140691
Homo sapiens Primates TRIF TRIF ncbigene_synonym TICAM1 148022
Homo sapiens Primates TRAF6 TRAF6 ncbigene_symbol TRAF6 7189
Homo sapiens Primates TRAF TRAF famplex_relations TRAF1 7185
Homo sapiens Primates TRAF TRAF famplex_relations TRAF2 7186
Homo sapiens Primates TRAF TRAF famplex_relations TRAF3 7187
Homo sapiens Primates TRAF TRAF famplex_relations TRAF4 9618
Homo sapiens Primates TRAF TRAF famplex_relations TRAF5 7188
Homo sapiens Primates TRAF TRAF famplex_relations TRAF7 84231
Homo sapiens Primates RXR RXR famplex_relations RXRA 6256
Homo sapiens Primates RXR RXR famplex_relations RXRB 6257
Homo sapiens Primates RXR RXR famplex_relations RXRG 6258
Homo sapiens Primates NIK NIK ncbigene_synonym MAP3K14 9020
Homo sapiens Primates NIK NIK ncbigene_synonym MAP4K4 9448
Homo sapiens Primates IKK IKK famplex_relations CHUK 1147
Homo sapiens Primates IKK IKK famplex_relations IKBKB 3551
Homo sapiens Primates IKK IKK famplex_relations IKBKG 8517
Homo sapiens Primates IKK IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKK IKK famplex_relations TBK1 29110
Homo sapiens Primates p65 P65 ncbigene_synonym RELA 5970
Homo sapiens Primates p65 P65 ncbigene_synonym SYT1 6857
Homo sapiens Primates p65 P65 ncbigene_synonym GORASP1 64689
Homo sapiens Primates p65 P65 ncbigene_synonym WNK1 65125
Homo sapiens Primates p50 P50 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates p50 P50 ncbigene_synonym ASCC1 51008
Homo sapiens Primates p50 P50 ncbigene_synonym H3P40 115482723
Homo sapiens Primates IL-23, IL-23 ncbigene_synonym IL37 27178
Homo sapiens Primates IL-23, IL-23 ncbigene_synonym IL23A 51561
Homo sapiens Primates IL-27 IL-27 ncbigene_synonym IL27 246778
Homo sapiens Primates Th1, TH1 ncbigene_synonym NELFCD 51497
Mus musculus Rodents PPAR PPAR ncbigene_synonym Ppara 19013
Mus musculus Rodents LPS LPS ncbigene_synonym Tlr4 21898
Mus musculus Rodents LBP LBP ncbigene_symbol Lbp 16803
Mus musculus Rodents LBP LBP ncbigene_synonym Ehhadh 74147
Mus musculus Rodents CD40L CD40L ncbigene_synonym Cd40lg 21947
Mus musculus Rodents CD14 CD14 ncbigene_symbol Cd14 12475
Mus musculus Rodents MD2 MD2 ncbigene_synonym Ly96 17087
Mus musculus Rodents CD40 CD40 ncbigene_symbol Cd40 21939
Mus musculus Rodents TLR9 TLR9 ncbigene_symbol Tlr9 81897
Mus musculus Rodents MyD88 MYD88 ncbigene_symbol Myd88 17874
Mus musculus Rodents TRIF TRIF ncbigene_synonym Rnf138 56515
Mus musculus Rodents TRIF TRIF ncbigene_synonym Trim69 70928
Mus musculus Rodents TRIF TRIF ncbigene_synonym Ticam1 106759
Mus musculus Rodents TRIF TRIF ncbigene_synonym Ticam2 225471
Mus musculus Rodents TRAF6 TRAF6 ncbigene_symbol Traf6 22034
Mus musculus Rodents NIK NIK ncbigene_synonym Map4k4 26921
Mus musculus Rodents NIK NIK ncbigene_synonym Map3k14 53859
Mus musculus Rodents I-KB IKB ncbigene_synonym Nfkbib 18036
Mus musculus Rodents p65 P65 ncbigene_synonym Rela 19697
Mus musculus Rodents p65 P65 ncbigene_synonym Gorasp1 74498
Mus musculus Rodents p50 P50 ncbigene_synonym Cdc37 12539
Mus musculus Rodents p50 P50 ncbigene_synonym Lsp1 16985
Mus musculus Rodents p50 P50 ncbigene_synonym Nfkb1 18033
Mus musculus Rodents p50 P50 ncbigene_synonym Pold2 18972
Mus musculus Rodents p50 P50 ncbigene_synonym Dctn2 69654
Mus musculus Rodents IL-23, IL-23 ncbigene_synonym Il23a 83430
Mus musculus Rodents IL-27 IL-27 ncbigene_synonym Ebi3 50498
Mus musculus Rodents IL-27 IL-27 ncbigene_synonym Il27 246779
Mus musculus Rodents Th1, TH1 ncbigene_synonym Hand1 15110
Mus musculus Rodents Th1, TH1 ncbigene_synonym Nelfcd 57314
Drosophila melanogaster Invertebrates LBP LBP ncbigene_synonym Mtpalpha 34276
Drosophila melanogaster Invertebrates TLR4 TLR4 ncbigene_synonym Toll-4 34235
Drosophila melanogaster Invertebrates MyD88 MYD88 ncbigene_symbol Myd88 35956
Drosophila melanogaster Invertebrates TRAF6 TRAF6 ncbigene_symbol Traf6 31746
Drosophila melanogaster Invertebrates TRAF TRAF ncbigene_synonym Traf4 33638
Drosophila melanogaster Invertebrates NIK NIK ncbigene_symbol Ni-K 252004
Drosophila melanogaster Invertebrates NIK NIK ncbigene_synonym msn 44030
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym IKKepsilon 35329
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym key 37967
Drosophila melanogaster Invertebrates IKK IKK ncbigene_synonym IKKbeta 44432
Drosophila melanogaster Invertebrates p65 P65 ncbigene_synonym dl 35047
Drosophila melanogaster Invertebrates p65 P65 ncbigene_synonym wash 36311
Drosophila melanogaster Invertebrates p50 P50 ncbigene_synonym Hrb27C 33968
Drosophila melanogaster Invertebrates p50 P50 ncbigene_synonym betaTub60D 37888
Drosophila melanogaster Invertebrates p50 P50 ncbigene_synonym Rpt5 42805
Drosophila melanogaster Invertebrates p50 P50 ncbigene_synonym DCTN2-p50 44086
Drosophila melanogaster Invertebrates Th1, TH1 ncbigene_symbol TH1 32607
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Danio rerio Vertebrates CD40 CD40 ncbigene_symbol cd40 100270764
Danio rerio Vertebrates TLR9 TLR9 ncbigene_symbol tlr9 403128
Danio rerio Vertebrates MyD88 MYD88 ncbigene_symbol myd88 403145
Danio rerio Vertebrates TRIF TRIF ncbigene_synonym ticam1 403147
Danio rerio Vertebrates TRAF6 TRAF6 ncbigene_symbol traf6 554561
Danio rerio Vertebrates RXR RXR ncbigene_synonym rxrga 30464
Danio rerio Vertebrates RXR RXR ncbigene_synonym rxrbb 30486
Danio rerio Vertebrates RXR RXR ncbigene_synonym rxrba 30530
Danio rerio Vertebrates RXR RXR ncbigene_synonym rxrab 793011
Danio rerio Vertebrates p65 P65 ncbigene_synonym rela 415099
Danio rerio Vertebrates p50 P50 ncbigene_synonym nfkb1 565756

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID