Chemical Rescue of ΔF508-CFTR Mimics Genetic Repair in Cystic Fibrosis Bronchial Epithelial Cells

CFTR-interacting HSP70 chaperones regulate cytokine expression. Literature-based HSP70 system protein-regulated expression of cytokine connectivity map was created using Pathway Architect software by customizing software tools for regulatory pathway specific for cytokine regulation. Blue squares, protein-protein interactions; purple squares, protein expression; green squares, regulation with positive/negative signs; green triangles, transport mechanism of cytokines; red ovals, specific set of HSP70 system proteins modulated by 4-PBA; blue ovals, multiple cytokines; and yellow ovals, receptor-associated factors regulated by 4-PBA-modulated proteins. The entire map is documented by 88 literature citations. TRAF, TNF receptor-associated factor; IKB, inhibitor of κ light polypeptide gene enhancer in B cells; NFKB, nuclear factor of κ light polypeptide gene enhancer in B cells; IFNG, interferon γ; STAT3, signal transducer and activator of transcription 3).

Publication

Chemical Rescue of ΔF508-CFTR Mimics Genetic Repair in Cystic Fibrosis Bronchial Epithelial Cells. (2008) Om V. Singh, et al. Mol Cell Proteomics. 2008 Jun;7(6):1099-1110. Figure: F6. Homo sapiens

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