Aged Retinal Pigment Epithelium/Choroid: A Potential Substratum for the Pathogenesis of Age-Related Macular Degeneration
Color nodes: genes that changed significantly in RPE/choroid from old animals with a fold change >2. Red: upregulation; green: downregulation. The diagram was modified from Ingenuity Pathway Analysis (Ingenuity® Systems).
Publication
The Aged Retinal Pigment Epithelium/Choroid: A Potential Substratum for the Pathogenesis of Age-Related Macular Degeneration. (2008) Huiyi Chen, et al. PLoS One. 2008;3(6):e2339. Figure: F3.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Mus musculus | Rodents | Tail | TA2 | ncbigene_synonym | Targ1 | 21360 |
| Mus musculus | Rodents | Tail | TA2 | ncbigene_synonym | Taar4 | 209513 |
| Mus musculus | Rodents | WASP | WASP | ncbigene_synonym | Was | 22376 |
| Mus musculus | Rodents | RhoA | RHOA | ncbigene_symbol | Rhoa | 11848 |
| Mus musculus | Rodents | Vav | VAV | ncbigene_synonym | Vav1 | 22324 |
| Mus musculus | Rodents | SPA-1 | SPA1 | ncbigene_synonym | Sipa1 | 20469 |
| Mus musculus | Rodents | SPA-1 | SPA1 | ncbigene_synonym | Spha1 | 100034905 |
| Mus musculus | Rodents | PYK2 | PYK2 | ncbigene_synonym | Ptk2b | 19229 |
| Mus musculus | Rodents | RAPL | RAPL | ncbigene_synonym | Rassf5 | 54354 |
| Mus musculus | Rodents | ÉRM | ERM | ncbigene_synonym | Etv5 | 104156 |
| Mus musculus | Rodents | Rep1 | REP1 | ncbigene_symbol | Rep1 | 104354 |
| Mus musculus | Rodents | Rep1 | REP1 | ncbigene_synonym | Chm | 12662 |
| Mus musculus | Rodents | Rep1 | REP1 | ncbigene_synonym | Msh3 | 17686 |
| Mus musculus | Rodents | Rep1 | REP1 | ncbigene_synonym | Sfpq | 71514 |
| Mus musculus | Rodents | ČD13 | CD13 | ncbigene_synonym | Anpep | 16790 |
| Mus musculus | Rodents | ÉPAC | EPAC | ncbigene_synonym | Rapgef3 | 223864 |
| Mus musculus | Rodents | CD44 | CD44 | ncbigene_symbol | Cd44 | 12505 |
| Mus musculus | Rodents | RhoH | RHOH | ncbigene_symbol | Rhoh | 74734 |
| Mus musculus | Rodents | SGL | SGL | ncbigene_symbol | sgl | 24054 |
| Mus musculus | Rodents | CAM | CAM | ncbigene_synonym | Calm1 | 12313 |
| Mus musculus | Rodents | CAM | CAM | ncbigene_synonym | Tmem50a | 71817 |
| Mus musculus | Rodents | THY1 | THY1 | ncbigene_symbol | Thy1 | 21838 |
| Mus musculus | Rodents | JAM | JAM | ncbigene_synonym | F11r | 16456 |
| Mus musculus | Rodents | MLLT4 | MLLT4 | ncbigene_synonym | Afdn | 17356 |
| Mus musculus | Rodents | Rap1 | RAP1 | ncbigene_synonym | Terf2ip | 57321 |
| Mus musculus | Rodents | Rap1 | RAP1 | ncbigene_synonym | Rap1a | 109905 |
| Mus musculus | Rodents | JAM2 | JAM2 | ncbigene_symbol | Jam2 | 67374 |
| Mus musculus | Rodents | Rac1 | RAC1 | ncbigene_symbol | Rac1 | 19353 |
| Mus musculus | Rodents | PÉCAN | PCAN | ncbigene_synonym | Podn | 242608 |
| Mus musculus | Rodents | ÍTGB) | TGB | ncbigene_synonym | Epm2a | 13853 |
| Mus musculus | Rodents | ÍTGB) | TGB | ncbigene_synonym | Ppbp | 57349 |
| Mus musculus | Rodents | NCF4 | NCF4 | ncbigene_symbol | Ncf4 | 17972 |
| Mus musculus | Rodents | FAK | FAK | ncbigene_synonym | Ptk2 | 14083 |
| Mus musculus | Rodents | CD99 | CD99 | ncbigene_symbol | Cd99 | 673094 |
| Mus musculus | Rodents | TIMP | TIMP | ncbigene_synonym | Timp1 | 21857 |
| Mus musculus | Rodents | CAS | CAS | ncbigene_synonym | Bcar1 | 12927 |
| Mus musculus | Rodents | CAS | CAS | ncbigene_synonym | Cse1l | 110750 |
| Mus musculus | Rodents | PXN | PXN | ncbigene_symbol | Pxn | 19303 |
| Mus musculus | Rodents | SHP2 | SHP2 | ncbigene_synonym | Ptpn11 | 19247 |
| Mus musculus | Rodents | CRK | CRK | ncbigene_symbol | Crk | 12928 |
| Homo sapiens | Primates | WASP | WASP | ncbigene_synonym | WAS | 7454 |
| Homo sapiens | Primates | RhoA | RHOA | ncbigene_symbol | RHOA | 387 |
| Homo sapiens | Primates | Vav | VAV | ncbigene_synonym | VAV1 | 7409 |
| Homo sapiens | Primates | Vav | VAV | famplex_relations | VAV2 | 7410 |
| Homo sapiens | Primates | Vav | VAV | famplex_relations | VAV3 | 10451 |
| Homo sapiens | Primates | SPA-1 | SPA1 | ncbigene_synonym | SIPA1 | 6494 |
| Homo sapiens | Primates | SPA-1 | SPA1 | ncbigene_synonym | SFTPA1 | 653509 |
| Homo sapiens | Primates | PYK2 | PYK2 | ncbigene_synonym | PTK2B | 2185 |
| Homo sapiens | Primates | RAPL | RAPL | ncbigene_synonym | RASSF5 | 83593 |
| Homo sapiens | Primates | Actin | ACTIN | famplex_relations | ACTA1 | 58 |
| Homo sapiens | Primates | Actin | ACTIN | famplex_relations | ACTA2 | 59 |
| Homo sapiens | Primates | Actin | ACTIN | famplex_relations | ACTB | 60 |
| Homo sapiens | Primates | Actin | ACTIN | famplex_relations | ACTC1 | 70 |
| Homo sapiens | Primates | Actin | ACTIN | famplex_relations | ACTG1 | 71 |
| Homo sapiens | Primates | Actin | ACTIN | famplex_relations | ACTG2 | 72 |
| Homo sapiens | Primates | ÉRM | ERM | ncbigene_synonym | ETV5 | 2119 |
| Homo sapiens | Primates | ÉRM | ERM | famplex_relations | EZR | 7430 |
| Homo sapiens | Primates | ÉRM | ERM | famplex_relations | RDX | 5962 |
| Homo sapiens | Primates | ÉRM | ERM | famplex_relations | MSN | 4478 |
| Homo sapiens | Primates | Rep1 | REP1 | ncbigene_synonym | CHM | 1121 |
| Homo sapiens | Primates | ČD13 | CD13 | ncbigene_synonym | ANPEP | 290 |
| Homo sapiens | Primates | ÉPAC | EPAC | ncbigene_synonym | RAPGEF3 | 10411 |
| Homo sapiens | Primates | ÉPAC | EPAC | ncbigene_synonym | RAPGEF4 | 11069 |
| Homo sapiens | Primates | CD44 | CD44 | ncbigene_symbol | CD44 | 960 |
| Homo sapiens | Primates | RhoH | RHOH | ncbigene_symbol | RHOH | 399 |
| Homo sapiens | Primates | TGB2 | TGB2 | ncbigene_synonym | PPBPP1 | 728045 |
| Homo sapiens | Primates | CAM | CAM | ncbigene_synonym | CALM1 | 801 |
| Homo sapiens | Primates | CAM | CAM | ncbigene_synonym | CALM2 | 805 |
| Homo sapiens | Primates | CAM | CAM | ncbigene_synonym | CALM3 | 808 |
| Homo sapiens | Primates | CAM | CAM | ncbigene_synonym | KRIT1 | 889 |
| Homo sapiens | Primates | CAM | CAM | ncbigene_synonym | CAMKMT | 79823 |
| Homo sapiens | Primates | THY1 | THY1 | ncbigene_symbol | THY1 | 7070 |
| Homo sapiens | Primates | JAM | JAM | ncbigene_synonym | F11R | 50848 |
| Homo sapiens | Primates | MLLT4 | MLLT4 | ncbigene_synonym | AFDN | 4301 |
| Homo sapiens | Primates | Rap1 | RAP1 | ncbigene_synonym | RAP1A | 5906 |
| Homo sapiens | Primates | Rap1 | RAP1 | ncbigene_synonym | RABGEF1 | 27342 |
| Homo sapiens | Primates | Rap1 | RAP1 | ncbigene_synonym | TERF2IP | 54386 |
| Homo sapiens | Primates | Rap1 | RAP1 | famplex_relations | RAP1B | 5908 |
| Homo sapiens | Primates | API | API | ncbigene_synonym | SERPINF2 | 5345 |
| Homo sapiens | Primates | JAM2 | JAM2 | ncbigene_symbol | JAM2 | 58494 |
| Homo sapiens | Primates | JAM2 | JAM2 | ncbigene_synonym | JAM3 | 83700 |
| Homo sapiens | Primates | Rac1 | RAC1 | ncbigene_symbol | RAC1 | 5879 |
| Homo sapiens | Primates | Rac1 | RAC1 | ncbigene_synonym | RNASE1 | 6035 |
| Homo sapiens | Primates | PÉCAN | PCAN | ncbigene_synonym | PODN | 127435 |
| Homo sapiens | Primates | ÍTGB) | TGB | ncbigene_synonym | PPBP | 5473 |
| Homo sapiens | Primates | ÍTGB) | ITGB | famplex_relations | ITGB1 | 3688 |
| Homo sapiens | Primates | ÍTGB) | ITGB | famplex_relations | ITGB2 | 3689 |
| Homo sapiens | Primates | ÍTGB) | ITGB | famplex_relations | ITGB3 | 3690 |
| Homo sapiens | Primates | ÍTGB) | ITGB | famplex_relations | ITGB4 | 3691 |
| Homo sapiens | Primates | ÍTGB) | ITGB | famplex_relations | ITGB5 | 3693 |
| Homo sapiens | Primates | ÍTGB) | ITGB | famplex_relations | ITGB6 | 3694 |
| Homo sapiens | Primates | ÍTGB) | ITGB | famplex_relations | ITGB7 | 3695 |
| Homo sapiens | Primates | ÍTGB) | ITGB | famplex_relations | ITGB8 | 3696 |
| Homo sapiens | Primates | ÍTGB) | ITGB | famplex_relations | ITGBL1 | 9358 |
| Homo sapiens | Primates | NCF4 | NCF4 | ncbigene_symbol | NCF4 | 4689 |
| Homo sapiens | Primates | FAK | FAK | ncbigene_synonym | PTK2 | 5747 |
| Homo sapiens | Primates | CD99 | CD99 | ncbigene_symbol | CD99 | 4267 |
| Homo sapiens | Primates | TIMP | TIMP | ncbigene_synonym | TIMP1 | 7076 |
| Homo sapiens | Primates | CAS | CAS | ncbigene_synonym | CSE1L | 1434 |
| Homo sapiens | Primates | CAS | CAS | ncbigene_synonym | CTNND1 | 1500 |
| Homo sapiens | Primates | CAS | CAS | ncbigene_synonym | BCAR1 | 9564 |
| Homo sapiens | Primates | CAS | CAS | ncbigene_synonym | TMX2-CTNND1 | 100528016 |
| Homo sapiens | Primates | AMP | AMP | ncbigene_synonym | APRT | 353 |
| Homo sapiens | Primates | AMP | AMP | ncbigene_synonym | MFAP1 | 4236 |
| Homo sapiens | Primates | PXN | PXN | ncbigene_symbol | PXN | 5829 |
| Homo sapiens | Primates | PXN | PXN | ncbigene_synonym | PXDN | 7837 |
| Homo sapiens | Primates | SHP2 | SHP2 | ncbigene_synonym | PTPN11 | 5781 |
| Homo sapiens | Primates | CRK | CRK | ncbigene_symbol | CRK | 1398 |
| Homo sapiens | Primates | CDHS | CDHS | ncbigene_synonym | PAX3 | 5077 |
| Rattus norvegicus | Rodents | Tail | TA2 | ncbigene_synonym | Taar4 | 294122 |
| Rattus norvegicus | Rodents | WASP | WASP | ncbigene_synonym | Was | 317371 |
| Rattus norvegicus | Rodents | RhoA | RHOA | ncbigene_symbol | Rhoa | 117273 |
| Rattus norvegicus | Rodents | Vav | VAV | ncbigene_synonym | Vav1 | 25156 |
| Rattus norvegicus | Rodents | SPA-1 | SPA-1 | ncbigene_synonym | Sipa1l1 | 246212 |
| Rattus norvegicus | Rodents | PYK2 | PYK2 | ncbigene_synonym | Ptk2b | 50646 |
| Rattus norvegicus | Rodents | ÉPAC | EPAC | ncbigene_synonym | Rapgef3 | 59326 |
| Rattus norvegicus | Rodents | CD44 | CD44 | ncbigene_symbol | Cd44 | 25406 |
| Rattus norvegicus | Rodents | RhoH | RHOH | ncbigene_symbol | Rhoh | 305341 |
| Rattus norvegicus | Rodents | CAM | CAM | ncbigene_synonym | Calm2 | 50663 |
| Rattus norvegicus | Rodents | THY1 | THY1 | ncbigene_symbol | Thy1 | 24832 |
| Rattus norvegicus | Rodents | CAM1 | CAM1 | ncbigene_synonym | Calm1 | 24242 |
| Rattus norvegicus | Rodents | MLLT4 | MLLT4 | ncbigene_synonym | Afdn | 26955 |
| Rattus norvegicus | Rodents | JAM2 | JAM2 | ncbigene_symbol | Jam2 | 619374 |
| Rattus norvegicus | Rodents | Rac1 | RAC1 | ncbigene_symbol | Rac1 | 363875 |
| Rattus norvegicus | Rodents | Rac1 | RAC1 | ncbigene_synonym | Rnase1l1 | 364303 |
| Rattus norvegicus | Rodents | NCF4 | NCF4 | ncbigene_symbol | Ncf4 | 500904 |
| Rattus norvegicus | Rodents | FAK | FAK | ncbigene_synonym | Ptk2 | 25614 |
| Rattus norvegicus | Rodents | CD99 | CD99 | ncbigene_symbol | Cd99 | 652929 |
| Rattus norvegicus | Rodents | TIMP | TIMP | ncbigene_synonym | Timp1 | 116510 |
| Rattus norvegicus | Rodents | CAS | CAS | ncbigene_synonym | Bcar1 | 25414 |
| Rattus norvegicus | Rodents | AMP | AMP | ncbigene_synonym | Tmprss5 | 266681 |
| Rattus norvegicus | Rodents | PXN | PXN | ncbigene_symbol | Pxn | 360820 |
| Rattus norvegicus | Rodents | SHP2 | SHP2 | ncbigene_synonym | Ptpn11 | 25622 |
| Rattus norvegicus | Rodents | CRK | CRK | ncbigene_symbol | Crk | 54245 |
| Capra hircus | Mammals | RhoA | RHOA | ncbigene_symbol | RHOA | 102181169 |
| Capra hircus | Mammals | CD44 | CD44 | ncbigene_symbol | CD44 | 102182426 |
| Capra hircus | Mammals | RhoH | RHOH | ncbigene_symbol | RHOH | 102174643 |
| Capra hircus | Mammals | THY1 | THY1 | ncbigene_symbol | THY1 | 102178188 |
| Capra hircus | Mammals | JAM2 | JAM2 | ncbigene_symbol | JAM2 | 102189619 |
| Capra hircus | Mammals | Rac1 | RAC1 | ncbigene_symbol | RAC1 | 102173438 |
| Capra hircus | Mammals | NCF4 | NCF4 | ncbigene_symbol | NCF4 | 102175930 |
| Capra hircus | Mammals | FAK | FAK | ncbigene_synonym | PTK2 | 102177814 |
| Capra hircus | Mammals | CD99 | CD99 | ncbigene_symbol | CD99 | 102180751 |
| Capra hircus | Mammals | PXN | PXN | ncbigene_symbol | PXN | 102178097 |
| Capra hircus | Mammals | CRK | CRK | ncbigene_symbol | CRK | 102174330 |
| Equus asinus | Mammals | RhoA | RHOA | ncbigene_symbol | RHOA | 106830690 |
| Equus asinus | Mammals | CD44 | CD44 | ncbigene_symbol | CD44 | 106837488 |
| Equus asinus | Mammals | RhoH | RHOH | ncbigene_symbol | RHOH | 106841286 |
| Equus asinus | Mammals | THY1 | THY1 | ncbigene_symbol | THY1 | 106840316 |
| Equus asinus | Mammals | JAM2 | JAM2 | ncbigene_symbol | JAM2 | 106842468 |
| Equus asinus | Mammals | Rac1 | RAC1 | ncbigene_symbol | RAC1 | 106840518 |
| Equus asinus | Mammals | NCF4 | NCF4 | ncbigene_symbol | NCF4 | 106837573 |
| Equus asinus | Mammals | CD99 | CD99 | ncbigene_symbol | CD99 | 106821911 |
| Equus asinus | Mammals | PXN | PXN | ncbigene_symbol | PXN | 106844784 |
| Equus asinus | Mammals | CRK | CRK | ncbigene_symbol | CRK | 106822010 |
| Oryctolagus cuniculus | Mammals | RhoA | RHOA | ncbigene_symbol | RHOA | 100340661 |
| Oryctolagus cuniculus | Mammals | CD44 | CD44 | ncbigene_symbol | CD44 | 100301546 |
| Oryctolagus cuniculus | Mammals | RhoH | RHOH | ncbigene_symbol | RHOH | 100356611 |
| Oryctolagus cuniculus | Mammals | CAM | CAM | ncbigene_synonym | CALM2 | 100352392 |
| Oryctolagus cuniculus | Mammals | THY1 | THY1 | ncbigene_symbol | THY1 | 100339279 |
| Oryctolagus cuniculus | Mammals | JAM2 | JAM2 | ncbigene_symbol | JAM2 | 100357246 |
| Oryctolagus cuniculus | Mammals | Rac1 | RAC1 | ncbigene_symbol | RAC1 | 100339873 |
| Oryctolagus cuniculus | Mammals | Rac1 | RAC1 | ncbigene_synonym | RHOG | 100008953 |
| Oryctolagus cuniculus | Mammals | NCF4 | NCF4 | ncbigene_symbol | NCF4 | 100009359 |
| Oryctolagus cuniculus | Mammals | PXN | PXN | ncbigene_symbol | PXN | 100353305 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | CkIIbeta | 32132 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | Andorra | 32798 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | Anp | 43595 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | Acam | 44913 |
| Drosophila melanogaster | Invertebrates | on | ON | ncbigene_symbol | On | 252296 |
| Drosophila melanogaster | Invertebrates | Tail | TAIL | ncbigene_synonym | Tailor | 40847 |
| Drosophila melanogaster | Invertebrates | WASP | WASP | ncbigene_symbol | WASp | 43402 |
| Drosophila melanogaster | Invertebrates | RhoA | RHOA | ncbigene_synonym | Rho1 | 36775 |
| Drosophila melanogaster | Invertebrates | mobi | MOBI | ncbigene_synonym | Mob2 | 39293 |
| Drosophila melanogaster | Invertebrates | Vav | VAV | ncbigene_symbol | Vav | 32920 |
| Drosophila melanogaster | Invertebrates | Actin | ACTIN | ncbigene_synonym | Act5C | 31521 |
| Drosophila melanogaster | Invertebrates | Actin | ACTIN | ncbigene_synonym | Act42A | 35526 |
| Drosophila melanogaster | Invertebrates | Actin | ACTIN | ncbigene_synonym | Act57B | 37368 |
| Drosophila melanogaster | Invertebrates | Actin | ACTIN | ncbigene_synonym | Act79B | 40444 |
| Drosophila melanogaster | Invertebrates | Actin | ACTIN | ncbigene_synonym | Act88F | 41885 |
| Drosophila melanogaster | Invertebrates | Actin | ACTIN | ncbigene_synonym | Act87E | 48632 |
| Drosophila melanogaster | Invertebrates | ÉRM | ERM | ncbigene_symbol | erm | 326152 |
| Drosophila melanogaster | Invertebrates | ÉRM | ERM | ncbigene_synonym | Moe | 31816 |
| Drosophila melanogaster | Invertebrates | Rep1 | REP1 | ncbigene_synonym | Drep1 | 36290 |
| Drosophila melanogaster | Invertebrates | ÉPAC | EPAC | ncbigene_symbol | Epac | 35588 |
| Drosophila melanogaster | Invertebrates | SGL | SGL | ncbigene_symbol | sgl | 38760 |
| Drosophila melanogaster | Invertebrates | CAM | CAM | ncbigene_symbol | Cam | 36329 |
| Drosophila melanogaster | Invertebrates | CAM | CAM | ncbigene_synonym | CaMKII | 43828 |
| Drosophila melanogaster | Invertebrates | Rap1 | RAP1 | ncbigene_symbol | Rap1 | 38244 |
| Drosophila melanogaster | Invertebrates | Rac1 | RAC1 | ncbigene_symbol | Rac1 | 38146 |
| Drosophila melanogaster | Invertebrates | Rac1 | RAC1 | ncbigene_synonym | Rac2 | 38831 |
| Drosophila melanogaster | Invertebrates | PÉCAN | PECAN | ncbigene_synonym | eIF4A | 33835 |
| Drosophila melanogaster | Invertebrates | HP:2 | HP2 | ncbigene_synonym | Su(var)2-HP2 | 36621 |
| Drosophila melanogaster | Invertebrates | FAK | FAK | ncbigene_symbol | Fak | 37233 |
| Drosophila melanogaster | Invertebrates | TIMP | TIMP | ncbigene_symbol | Timp | 41248 |
| Drosophila melanogaster | Invertebrates | CAS | CAS | ncbigene_symbol | cas | 44018 |
| Drosophila melanogaster | Invertebrates | CAS | CAS | ncbigene_synonym | caz | 32587 |
| Drosophila melanogaster | Invertebrates | CAS | CAS | ncbigene_synonym | Cse1 | 35016 |
| Drosophila melanogaster | Invertebrates | CAS | CAS | ncbigene_synonym | cass | 35053 |
| Drosophila melanogaster | Invertebrates | CAS | CAS | ncbigene_synonym | cash | 47266 |
| Drosophila melanogaster | Invertebrates | CR | CR | ncbigene_symbol | CR | 5657006 |
| Drosophila melanogaster | Invertebrates | AMP | AMP | ncbigene_synonym | Amph | 36383 |
| Drosophila melanogaster | Invertebrates | PXN | PXN | ncbigene_symbol | Pxn | 38326 |
| Drosophila melanogaster | Invertebrates | PXN | PXN | ncbigene_synonym | Pax | 35215 |
| Drosophila melanogaster | Invertebrates | SHP2 | SHP2 | ncbigene_synonym | csw | 45278 |
| Drosophila melanogaster | Invertebrates | CRK | CRK | ncbigene_symbol | Crk | 43775 |
| Drosophila melanogaster | Invertebrates | CRK | CRK | ncbigene_synonym | NA | 32026 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|