Major pathways affected by TFIIS knockdown in MCF7

Major pathways affected by TFIIS knockdown in MCF7. Network analysis employed Ingenuity® Systems software [31]. The software manufacturer maintains a copyright on the image networks. The Ingenuity networks display in color focus genes that are upregulated (green) and downregulated (red) by other proteins. The affect can be direct (solid lines) or indirect (broken lines). Triangle's represent kinases, diamonds enzymes, ovals Transcription regulators, rectangles G–Protein Coupled receptors and circles, other. The pathway represents MCF7 pathway 1. A list of focus genes for each pathway is provided in Additional file .
Major pathways affected by TFIIS knockdown in MCF7
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Publication

Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis. (2008) Kyle Hubbard, et al. BMC Cancer. 2008;8:133-133. Figure: F8.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates RPL27 RPL27 ncbigene_symbol RPL27 6155
Homo sapiens Primates SLC25A19 SLC25A19 ncbigene_symbol SLC25A19 60386
Homo sapiens Primates RPL41c-Mye/N-Myc N-MYC ncbigene_synonym MYCN 4613
Homo sapiens Primates RPL41 RPL41 ncbigene_symbol RPL41 6171
Homo sapiens Primates RPL21 RPL21 ncbigene_symbol RPL21 6144
Homo sapiens Primates RPL35 RPL35 ncbigene_symbol RPL35 11224
Homo sapiens Primates RPS23 RPS23 ncbigene_symbol RPS23 6228
Homo sapiens Primates RPL18 RPL18 ncbigene_symbol RPL18 6141
Homo sapiens Primates MYC MYC ncbigene_symbol MYC 4609
Homo sapiens Primates KITLG KITLG ncbigene_symbol KITLG 4254
Homo sapiens Primates RPL23 RPL23 ncbigene_symbol RPL23 9349
Homo sapiens Primates RPL23 RPL23 ncbigene_synonym RPL17 6139
Homo sapiens Primates RPL23 RPL23 ncbigene_synonym MRPL23 6150
Homo sapiens Primates CDKN2A CDKN2A ncbigene_symbol CDKN2A 1029
Homo sapiens Primates BRD2 BRD2 ncbigene_symbol BRD2 6046
Homo sapiens Primates TP53 TP53 ncbigene_symbol TP53 7157
Homo sapiens Primates FGFR3 FGFR3 ncbigene_symbol FGFR3 2261
Homo sapiens Primates GTF2B GTF2B ncbigene_symbol GTF2B 2959
Homo sapiens Primates IRAK1 IRAK1 ncbigene_symbol IRAK1 3654
Homo sapiens Primates BLZF1 BLZF1 ncbigene_symbol BLZF1 8548
Homo sapiens Primates SMARCA4 SMARCA4 ncbigene_symbol SMARCA4 6597
Homo sapiens Primates AR AR ncbigene_symbol AR 367
Homo sapiens Primates охcfi CFI ncbigene_symbol CFI 3426
Homo sapiens Primates SMARCC2 SMARCC2 ncbigene_symbol SMARCC2 6601
Homo sapiens Primates HIP1 HIP1 ncbigene_symbol HIP1 3092
Homo sapiens Primates HIP1 HIP1 ncbigene_synonym SETD2 29072
Homo sapiens Primates SERPINB5 SERPINB5 ncbigene_symbol SERPINB5 5268
Homo sapiens Primates CFHR4 CFHR4 ncbigene_symbol CFHR4 10877
Homo sapiens Primates NRP2 NRP2 ncbigene_symbol NRP2 8828
Homo sapiens Primates NRP2 NRP2 ncbigene_synonym NELL2 4753
Homo sapiens Primates MDH1 MDH1 ncbigene_symbol MDH1 4190
Homo sapiens Primates PLXNA3 PLXNA3 ncbigene_symbol PLXNA3 55558
Rattus norvegicus Rodents RPL27 RPL27 ncbigene_symbol Rpl27 64306
Rattus norvegicus Rodents SLC25A19 SLC25A19 ncbigene_symbol Slc25a19 303676
Rattus norvegicus Rodents RPL41c-Mye/N-Myc N-MYC ncbigene_synonym Mycn 298894
Rattus norvegicus Rodents RPL41 RPL41 ncbigene_symbol Rpl41 124440
Rattus norvegicus Rodents RPL21 RPL21 ncbigene_symbol Rpl21 79449
Rattus norvegicus Rodents RPL35 RPL35 ncbigene_symbol Rpl35 296709
Rattus norvegicus Rodents RPS23 RPS23 ncbigene_symbol Rps23 124323
Rattus norvegicus Rodents RPL18 RPL18 ncbigene_symbol Rpl18 81766
Rattus norvegicus Rodents MYC MYC ncbigene_symbol Myc 24577
Rattus norvegicus Rodents KITLG KITLG ncbigene_symbol Kitlg 60427
Rattus norvegicus Rodents RPL23 RPL23 ncbigene_symbol Rpl23 29282
Rattus norvegicus Rodents RPL23 RPL23 ncbigene_synonym Rpl17 291434
Rattus norvegicus Rodents CDKN2A CDKN2A ncbigene_symbol Cdkn2a 25163
Rattus norvegicus Rodents BRD2 BRD2 ncbigene_symbol Brd2 294276
Rattus norvegicus Rodents TP53 TP53 ncbigene_symbol Tp53 24842
Rattus norvegicus Rodents FGFR3 FGFR3 ncbigene_symbol Fgfr3 84489
Rattus norvegicus Rodents GTF2B GTF2B ncbigene_symbol Gtf2b 81673
Rattus norvegicus Rodents IRAK1 IRAK1 ncbigene_symbol Irak1 363520
Rattus norvegicus Rodents BLZF1 BLZF1 ncbigene_symbol Blzf1 498266
Rattus norvegicus Rodents SMARCA4 SMARCA4 ncbigene_symbol Smarca4 171379
Rattus norvegicus Rodents AR AR ncbigene_symbol Ar 24208
Rattus norvegicus Rodents охcfi CFI ncbigene_symbol Cfi 79126
Rattus norvegicus Rodents SMARCC2 SMARCC2 ncbigene_symbol Smarcc2 685179
Rattus norvegicus Rodents HIP1 HIP1 ncbigene_symbol Hip1 192154
Rattus norvegicus Rodents SERPINB5 SERPINB5 ncbigene_symbol Serpinb5 116589
Rattus norvegicus Rodents CFHR4 CFHR4 ncbigene_symbol Cfhr4 498241
Rattus norvegicus Rodents NRP2 NRP2 ncbigene_symbol Nrp2 81527
Rattus norvegicus Rodents MDH1 MDH1 ncbigene_symbol Mdh1 24551
Rattus norvegicus Rodents PLXNA3 PLXNA3 ncbigene_symbol Plxna3 309280
Bos taurus Mammals RPL27 RPL27 ncbigene_symbol RPL27 404137
Bos taurus Mammals SLC25A19 SLC25A19 ncbigene_symbol SLC25A19 504418
Bos taurus Mammals RPL21 RPL21 ncbigene_symbol RPL21 326584
Bos taurus Mammals RPL35 RPL35 ncbigene_symbol RPL35 515534
Bos taurus Mammals RPL35 RPL35 ncbigene_synonym RPL36 768327
Bos taurus Mammals RPS23 RPS23 ncbigene_symbol RPS23 540129
Bos taurus Mammals MYCN MYCN ncbigene_symbol MYCN 616888
Bos taurus Mammals RPL18 RPL18 ncbigene_symbol RPL18 509163
Bos taurus Mammals MYC MYC ncbigene_symbol MYC 511077
Bos taurus Mammals KITLG KITLG ncbigene_symbol KITLG 281885
Bos taurus Mammals RPL23 RPL23 ncbigene_symbol RPL23 504876
Bos taurus Mammals CDKN2A CDKN2A ncbigene_symbol CDKN2A 616369
Bos taurus Mammals BRD2 BRD2 ncbigene_symbol BRD2 505358
Bos taurus Mammals TP53 TP53 ncbigene_symbol TP53 281542
Bos taurus Mammals FGFR3 FGFR3 ncbigene_symbol FGFR3 281769
Bos taurus Mammals GTF2B GTF2B ncbigene_symbol GTF2B 513231
Bos taurus Mammals IRAK1 IRAK1 ncbigene_symbol IRAK1 533953
Bos taurus Mammals BLZF1 BLZF1 ncbigene_symbol BLZF1 504820
Bos taurus Mammals SMARCA4 SMARCA4 ncbigene_symbol SMARCA4 414274
Bos taurus Mammals AR AR ncbigene_symbol AR 280675
Bos taurus Mammals охcfi CFI ncbigene_symbol CFI 513197
Bos taurus Mammals SMARCC2 SMARCC2 ncbigene_symbol SMARCC2 509060
Bos taurus Mammals HIP1 HIP1 ncbigene_symbol HIP1 505919
Bos taurus Mammals SERPINB5 SERPINB5 ncbigene_symbol SERPINB5 534323
Bos taurus Mammals NRP2 NRP2 ncbigene_symbol NRP2 541004
Bos taurus Mammals MDH1 MDH1 ncbigene_symbol MDH1 535182
Bos taurus Mammals PLXNA3 PLXNA3 ncbigene_symbol PLXNA3 782382
Mus musculus Rodents RPL27 RPL27 ncbigene_symbol Rpl27 19942
Mus musculus Rodents SLC25A19 SLC25A19 ncbigene_symbol Slc25a19 67283
Mus musculus Rodents RPL41c-Mye/N-Myc N-MYC ncbigene_synonym Mycn 18109
Mus musculus Rodents RPL41 RPL41 ncbigene_symbol Rpl41 67945
Mus musculus Rodents RPL21 RPL21 ncbigene_symbol Rpl21 19933
Mus musculus Rodents RPL35 RPL35 ncbigene_symbol Rpl35 66489
Mus musculus Rodents RPL35 RPL35 ncbigene_synonym Rpl35a 57808
Mus musculus Rodents RPS23 RPS23 ncbigene_symbol Rps23 66475
Mus musculus Rodents RPL18 RPL18 ncbigene_symbol Rpl18 19899
Mus musculus Rodents MYC MYC ncbigene_symbol Myc 17869
Mus musculus Rodents MYC MYC ncbigene_synonym Nol3 78688
Mus musculus Rodents KITLG KITLG ncbigene_synonym Kitl 17311
Mus musculus Rodents RPL23 RPL23 ncbigene_symbol Rpl23 65019
Mus musculus Rodents RPL23 RPL23 ncbigene_synonym Mrpl23 19935
Mus musculus Rodents RPL23 RPL23 ncbigene_synonym D7Zem4 27546
Mus musculus Rodents CDKN2A CDKN2A ncbigene_symbol Cdkn2a 12578
Mus musculus Rodents BRD2 BRD2 ncbigene_symbol Brd2 14312
Mus musculus Rodents TP53 TP53 ncbigene_synonym Trp53 22059
Mus musculus Rodents FGFR3 FGFR3 ncbigene_symbol Fgfr3 14184
Mus musculus Rodents GTF2B GTF2B ncbigene_symbol Gtf2b 229906
Mus musculus Rodents IRAK1 IRAK1 ncbigene_symbol Irak1 16179
Mus musculus Rodents BLZF1 BLZF1 ncbigene_symbol Blzf1 66352
Mus musculus Rodents SMARCA4 SMARCA4 ncbigene_symbol Smarca4 20586
Mus musculus Rodents AR AR ncbigene_symbol Ar 11835
Mus musculus Rodents охcfi CFI ncbigene_symbol Cfi 12630
Mus musculus Rodents SMARCC2 SMARCC2 ncbigene_symbol Smarcc2 68094
Mus musculus Rodents HIP1 HIP1 ncbigene_symbol Hip1 215114
Mus musculus Rodents SERPINB5 SERPINB5 ncbigene_symbol Serpinb5 20724
Mus musculus Rodents CFHR4 CFHR4 ncbigene_symbol Cfhr4 214403
Mus musculus Rodents NRP2 NRP2 ncbigene_symbol Nrp2 18187
Mus musculus Rodents MDH1 MDH1 ncbigene_symbol Mdh1 17449
Mus musculus Rodents MDH1 MDH1 ncbigene_synonym Me1 17436
Mus musculus Rodents PLXNA3 PLXNA3 ncbigene_symbol Plxna3 18846
Schizosaccharomyces pombe Plants and Fungi RPL41 RPL41 ncbigene_synonym rpl401 2539780
Schizosaccharomyces pombe Plants and Fungi RPL41 RPL41 ncbigene_synonym rpl4102 2543180
Schizosaccharomyces pombe Plants and Fungi RPL21 RPL21 ncbigene_synonym rpl2101 2540950
Schizosaccharomyces pombe Plants and Fungi RPL21 RPL21 ncbigene_synonym rpl2102 2543337
Schizosaccharomyces pombe Plants and Fungi RPL21 RPL21 ncbigene_synonym rpl801 5802952
Schizosaccharomyces pombe Plants and Fungi RPL35 RPL35 ncbigene_symbol rpl35 2539308
Schizosaccharomyces pombe Plants and Fungi RPS23 RPS23 ncbigene_symbol rps23 2542012
Schizosaccharomyces pombe Plants and Fungi RPL18 RPL18 ncbigene_synonym rpl1801 2539678
Schizosaccharomyces pombe Plants and Fungi HIP1 HIP1 ncbigene_symbol hip1 2540219
Danio rerio Vertebrates RPL27 RPL27 ncbigene_symbol rpl27 325618
Danio rerio Vertebrates SLC25A19 SLC25A19 ncbigene_symbol slc25a19 403024
Danio rerio Vertebrates RPL41c-Mye/N-Myc N-MYC ncbigene_synonym mycn 252851
Danio rerio Vertebrates RPL41 RPL41 ncbigene_synonym si:dkey-151g10.6 335588
Danio rerio Vertebrates RPL21 RPL21 ncbigene_symbol rpl21 336568
Danio rerio Vertebrates RPL35 RPL35 ncbigene_symbol rpl35 192299
Danio rerio Vertebrates RPS23 RPS23 ncbigene_symbol rps23 100000341
Danio rerio Vertebrates RPL18 RPL18 ncbigene_symbol rpl18 445038
Danio rerio Vertebrates MYC MYC ncbigene_synonym myca 30686
Danio rerio Vertebrates MYC MYC ncbigene_synonym mycbp2 368439
Danio rerio Vertebrates RPL23 RPL23 ncbigene_symbol rpl23 336812
Danio rerio Vertebrates BRD2 BRD2 ncbigene_synonym brd2a 30445
Danio rerio Vertebrates TP53 TP53 ncbigene_symbol tp53 30590
Danio rerio Vertebrates FGFR3 FGFR3 ncbigene_symbol fgfr3 58129
Danio rerio Vertebrates GTF2B GTF2B ncbigene_symbol gtf2b 324823
Danio rerio Vertebrates IRAK1 IRAK1 ncbigene_symbol irak1 569226
Danio rerio Vertebrates BLZF1 BLZF1 ncbigene_symbol blzf1 114452
Danio rerio Vertebrates SMARCA4 SMARCA4 ncbigene_synonym smarca4a 353295
Danio rerio Vertebrates AR AR ncbigene_symbol ar 100005148
Danio rerio Vertebrates охcfi CFI ncbigene_symbol cfi 557557
Danio rerio Vertebrates SMARCC2 SMARCC2 ncbigene_symbol smarcc2 567476
Danio rerio Vertebrates HIP1 HIP1 ncbigene_symbol hip1 793823
Danio rerio Vertebrates MDH1 MDH1 ncbigene_synonym mdh1ab 335715
Danio rerio Vertebrates MDH1 MDH1 ncbigene_synonym mdh1aa 399662
Danio rerio Vertebrates PLXNA3 PLXNA3 ncbigene_symbol plxna3 567422

Chemical mentions

Word Match MeSH Name ChEBI
estradiol Estradiol mesh:D004958 17beta-estradiol chebi:16469

Disease mentions

Word Match MeSH Name DOID