Autocrine/paracrine induction of osteogenesis in hMSCs by PKA signaling

Model for autocrine/paracrine induction of osteogenesis in hMSCs by PKA signaling. db-cAMP induces direct expression of BMP target genes such as ID-2 and ID-4 via CREB resulting in cell-autonomous stimulation of osteogenesis whereas expression of BMP-2, proosteogenic cytokines, and growth factors results in paracrine induction of bone formation.
Autocrine/paracrine induction of osteogenesis in hMSCs by PKA signaling
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Publication

cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo. (2008) Ramakrishnaiah Siddappa, et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7281-7286. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates ATP ATP ncbigene_synonym ATP8A2 51761
Homo sapiens Primates PKA PKA famplex_relations PRKAR1A 5573
Homo sapiens Primates PKA PKA famplex_relations PRKAR1B 5575
Homo sapiens Primates PKA PKA famplex_relations PRKAR2A 5576
Homo sapiens Primates PKA PKA famplex_relations PRKAR2B 5577
Homo sapiens Primates PKA PKA famplex_relations PRKACA 5566
Homo sapiens Primates PKA PKA famplex_relations PRKACB 5567
Homo sapiens Primates PKA PKA famplex_relations PRKACG 5568
Homo sapiens Primates CREB CREB ncbigene_synonym CREB1 1385
Homo sapiens Primates CREB CREB famplex_relations CREB3 10488
Homo sapiens Primates CREB CREB famplex_relations CREB5 9586
Homo sapiens Primates CREB CREB famplex_relations CREB3L1 90993
Homo sapiens Primates CREB CREB famplex_relations CREB3L2 64764
Homo sapiens Primates CREB CREB famplex_relations CREB3L3 84699
Homo sapiens Primates CREB CREB famplex_relations CREB3L4 148327
Homo sapiens Primates CREB CREB famplex_relations CREM 1390
Homo sapiens Primates CREB CREB famplex_relations ATF1 466
Homo sapiens Primates CREB CREB famplex_relations ATF2 1386
Homo sapiens Primates ID2, ID2 ncbigene_symbol ID2 3398
Homo sapiens Primates FosB FOSB ncbigene_symbol FOSB 2354
Homo sapiens Primates ID4, ID4 ncbigene_symbol ID4 3400
Homo sapiens Primates ID2,ID4,SMAD6,FosB SMAD6 ncbigene_symbol SMAD6 4091
Homo sapiens Primates IL-11, IL-11 ncbigene_synonym IL11 3589
Homo sapiens Primates IGF-1, IGF1 ncbigene_symbol IGF1 3479
Homo sapiens Primates BMP2 BMP2 ncbigene_symbol BMP2 650
Homo sapiens Primates TGF-B TGFB ncbigene_synonym TGFB1 7040
Homo sapiens Primates TGF-B TGFB famplex_relations TGFB2 7042
Homo sapiens Primates TGF-B TGFB famplex_relations TGFB3 7043

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID