Illustrations of the 5 Alpha-reductase action and the pathway of androgen action on target gene expression

Illustrations of the 5 α-reductase action and the pathway of androgen action on target gene expression. 5α-reductases (5αRD) converts testosterone (T) to dihydrotestosterone (DHT) in the cell (top panel). Both T and DHT bind to androgen receptor (AR), resulting in a conformational change in AR and translocation of the receptor complex to nucleus. This complex interacts with androgen response element (ARE) on the target gene, and induces gene expression in concert with coregulators (SRC1, CBP, SRA), transcription factors (TF) and the general transcription complex. The function of AR can be activated or modified by non-ligand factors such as growth factors.
Illustrations of the 5 Alpha-reductase action and the pathway of androgen action on target gene expression
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Publication

5α-Reductase Isozymes in the Prostate. () Yuan-Shan Zhu, et al. J Med Sci. ;25(1):1-12. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates Sa- SA ncbigene_symbol SA 33974
Drosophila melanogaster Invertebrates Sa- SA ncbigene_symbol sa 40367
Drosophila melanogaster Invertebrates AR AR ncbigene_symbol ar 44503
Drosophila melanogaster Invertebrates LAR LAR ncbigene_symbol Lar 35259
Drosophila melanogaster Invertebrates LAR LAR ncbigene_synonym larv 45985
Drosophila melanogaster Invertebrates AB AB ncbigene_symbol ab 34560
Drosophila melanogaster Invertebrates AB AB ncbigene_synonym Appl 31002
Drosophila melanogaster Invertebrates CB CB ncbigene_symbol cb 247976
Drosophila melanogaster Invertebrates SRA SRA ncbigene_symbol sra 47384
Drosophila melanogaster Invertebrates SRA SRA ncbigene_synonym Cyfip 41861
Drosophila melanogaster Invertebrates SRCI SRCI ncbigene_symbol Sr-CI 33621
Drosophila melanogaster Invertebrates EGF EGF ncbigene_synonym Egfr 37455
Homo sapiens Primates AR AR ncbigene_symbol AR 367
Homo sapiens Primates LAR LAR ncbigene_synonym PTPRF 5792
Homo sapiens Primates AB AB ncbigene_synonym APP 351
Homo sapiens Primates AB AB ncbigene_synonym SUCLA2 8803
Homo sapiens Primates polymerase POLYMERASE ncbigene_synonym ERVK-9 100616102
Homo sapiens Primates polymerase POLYMERASE ncbigene_synonym ERVK-11 100862688
Homo sapiens Primates polymerase POLYMERASE ncbigene_synonym ERVK-19 105376906
Homo sapiens Primates SRA SRA ncbigene_synonym MSR1 4481
Homo sapiens Primates SRA SRA ncbigene_synonym SRPRA 6734
Homo sapiens Primates SRA SRA ncbigene_synonym SRA1 10011
Homo sapiens Primates SRA SRA ncbigene_synonym APBB3 10307
Homo sapiens Primates SARD SARD ncbigene_synonym SARDH 1757
Homo sapiens Primates EGF EGF ncbigene_symbol EGF 1950
Homo sapiens Primates IGF1 IGF1 ncbigene_symbol IGF1 3479
Homo sapiens Primates TGFA TGFA ncbigene_symbol TGFA 7039

Chemical mentions

Word Match MeSH Name ChEBI
Dopamine Dopamine mesh:D004298 dopamine chebi:18243
Dihydrotestosterone Dihydrotestosterone mesh:D013196 17beta-hydroxy-5alpha-androstan-3-one chebi:16330
Steroids Steroids mesh:D013256 steroid chebi:35341
Testosterone Testosterone mesh:D013739 testosterone chebi:17347

Disease mentions

Word Match MeSH Name DOID