Stimulus Design for Model Selection and Validation in Cell Signaling
This schematic shows the major steps in EGFR signaling. At the top of the pathway ligand binds to the receptor and induces receptor dimerization and activation. The signal is then transduced through a series of adaptor proteins SHC, GRB2, and SOS, which in turn activates the MAPK cascade RAF, MEK and ERK. There are two negative feedback loops: internalization and degradation of the receptor complex, and ERK deactivation of SOS.
Publication
Stimulus Design for Model Selection and Validation in Cell Signaling . (2008) Joshua F Apgar, et al. PLoS Comput Biol. 2008 Feb;4(2):e30. Figure: F4.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | EGF | EGF | ncbigene_synonym | Egfr | 37455 |
| Drosophila melanogaster | Invertebrates | SHC | SHC | ncbigene_symbol | Shc | 44052 |
| Drosophila melanogaster | Invertebrates | GRB2 | GRB2 | ncbigene_synonym | drk | 36497 |
| Drosophila melanogaster | Invertebrates | soS | SOS | ncbigene_symbol | Sos | 34790 |
| Drosophila melanogaster | Invertebrates | RAS | RAS | ncbigene_symbol | ras | 43873 |
| Drosophila melanogaster | Invertebrates | RAS | RAS | ncbigene_synonym | Ras64B | 38494 |
| Drosophila melanogaster | Invertebrates | RAS | RAS | ncbigene_synonym | Ras85D | 41140 |
| Drosophila melanogaster | Invertebrates | RAF | RAF | ncbigene_symbol | Raf | 31221 |
| Drosophila melanogaster | Invertebrates | MEK | MEK | ncbigene_synonym | Dsor1 | 31872 |
| Drosophila melanogaster | Invertebrates | MEK | MEK | ncbigene_synonym | Mtk | 36708 |
| Drosophila melanogaster | Invertebrates | ERK | ERK | ncbigene_synonym | Erk7 | 31877 |
| Drosophila melanogaster | Invertebrates | ERK | ERK | ncbigene_synonym | rl | 3354888 |
| Homo sapiens | Primates | EGF | EGF | ncbigene_symbol | EGF | 1950 |
| Homo sapiens | Primates | EGFR | EGFR | ncbigene_symbol | EGFR | 1956 |
| Homo sapiens | Primates | SHC | SHC | ncbigene_synonym | SHC1 | 6464 |
| Homo sapiens | Primates | SHC | SHC | famplex_relations | SHC2 | 25759 |
| Homo sapiens | Primates | SHC | SHC | famplex_relations | SHC3 | 53358 |
| Homo sapiens | Primates | SHC | SHC | famplex_relations | SHC4 | 399694 |
| Homo sapiens | Primates | GRB2 | GRB2 | ncbigene_symbol | GRB2 | 2885 |
| Homo sapiens | Primates | soS | SOS | ncbigene_synonym | XYLT2 | 64132 |
| Homo sapiens | Primates | soS | SOS | famplex_relations | SOS1 | 6654 |
| Homo sapiens | Primates | soS | SOS | famplex_relations | SOS2 | 6655 |
| Homo sapiens | Primates | RAS | RAS | famplex_relations | KRAS | 3845 |
| Homo sapiens | Primates | RAS | RAS | famplex_relations | HRAS | 3265 |
| Homo sapiens | Primates | RAS | RAS | famplex_relations | NRAS | 4893 |
| Homo sapiens | Primates | RAF | RAF | ncbigene_synonym | ZHX2 | 22882 |
| Homo sapiens | Primates | RAF | RAF | famplex_relations | ARAF | 369 |
| Homo sapiens | Primates | RAF | RAF | famplex_relations | BRAF | 673 |
| Homo sapiens | Primates | RAF | RAF | famplex_relations | RAF1 | 5894 |
| Homo sapiens | Primates | MEK | MEK | ncbigene_synonym | MAP2K7 | 5609 |
| Homo sapiens | Primates | MEK | MEK | famplex_relations | MAP2K1 | 5604 |
| Homo sapiens | Primates | MEK | MEK | famplex_relations | MAP2K2 | 5605 |
| Homo sapiens | Primates | ERK | ERK | ncbigene_synonym | EPHB2 | 2048 |
| Homo sapiens | Primates | ERK | ERK | ncbigene_synonym | MAPK1 | 5594 |
| Homo sapiens | Primates | ERK | ERK | famplex_relations | MAPK3 | 5595 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| Cancer | NA | |||
| Cardiomyopathy | NA | |||
| Lung cancer | NA | |||
| Noonan syndrome | NA |