Extracellular and intracellular antagonism of BMP signaling by myostatin and TGFB

Model of extracellular and intracellular antagonism of BMP signaling by myostatin and TGF-β. Myostatin signals through ActRIIB and either ALK4 or ALK5 to activate a TGF-β-like signaling pathway. Myostatin potently antagonizes BMP7 but not BMP2 by competing for BMP7 binding to the ActRIIB type II receptor.
Extracellular and intracellular antagonism of BMP signaling by myostatin and TGFB
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Publication

Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis. (2003) A. Rebbapragada, et al. Mol Cell Biol. 2003 Oct;23(20):7230-7242. Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents myo MYO ncbigene_synonym Myog 17928
Mus musculus Rodents myo MYO ncbigene_synonym Synpo2 118449
Mus musculus Rodents BMP2 BMP2 ncbigene_symbol Bmp2 12156
Mus musculus Rodents BMP2 BMP2 ncbigene_synonym Bmpr2 12168
Mus musculus Rodents BMP7 BMP7 ncbigene_symbol Bmp7 12162
Mus musculus Rodents ActRIIB ACTRIIB ncbigene_synonym Acvr2b 11481
Mus musculus Rodents (ActRI/BMPRII) ACTRI ncbigene_synonym Acvr1 11477
Mus musculus Rodents ALK4 ALK4 ncbigene_synonym Acvr1b 11479
Mus musculus Rodents ALK5 ALK5 ncbigene_synonym Tgfbr1 21812
Mus musculus Rodents ALK3 ALK3 ncbigene_synonym Bmpr1a 12166
Mus musculus Rodents Smad2 SMAD2 ncbigene_symbol Smad2 17126
Mus musculus Rodents Smad2/3 SMAD3 ncbigene_symbol Smad3 17127
Mus musculus Rodents Smad1/5/8 SMAD5 ncbigene_symbol Smad5 17129
Mus musculus Rodents Smad1/5/8 SMAD1 ncbigene_symbol Smad1 17125
Mus musculus Rodents Smad1/5/8 SMAD8 ncbigene_synonym Smad9 55994
Homo sapiens Primates BMP2 BMP2 ncbigene_symbol BMP2 650
Homo sapiens Primates BMP7 BMP7 ncbigene_symbol BMP7 655
Homo sapiens Primates ActRIIB ACTRIIB ncbigene_synonym ACVR2B 93
Homo sapiens Primates (ActRI/BMPRII) BMPRII ncbigene_synonym BMPR2 659
Homo sapiens Primates (ActRI/BMPRII) ACTRI ncbigene_synonym ACVR1 90
Homo sapiens Primates ALK4 ALK4 ncbigene_synonym ACVR1B 91
Homo sapiens Primates ALK5 ALK5 ncbigene_synonym TGFBR1 7046
Homo sapiens Primates ALK3 ALK3 ncbigene_synonym BMPR1A 657
Homo sapiens Primates Smad2 SMAD2 ncbigene_symbol SMAD2 4087
Homo sapiens Primates Smad2/3 SMAD3 ncbigene_symbol SMAD3 4088
Homo sapiens Primates Smad1/5/8 SMAD5 ncbigene_symbol SMAD5 4090
Homo sapiens Primates Smad1/5/8 SMAD1 ncbigene_symbol SMAD1 4086
Homo sapiens Primates Smad1/5/8 SMAD1 ncbigene_synonym GARS1 2617
Homo sapiens Primates Smad1/5/8 SMAD8 ncbigene_synonym SMAD9 4093
Danio rerio Vertebrates BMP2 BMP2 ncbigene_synonym bmp2a 30631
Danio rerio Vertebrates BMP2 BMP2 ncbigene_synonym bmp2b 30632
Danio rerio Vertebrates BMP7 BMP7 ncbigene_synonym bmp7a 30584
Danio rerio Vertebrates ActRIIB ACTRIIB ncbigene_synonym acvr2ba 30457
Danio rerio Vertebrates ALK4 ALK4 ncbigene_synonym acvr1ba 30183
Danio rerio Vertebrates ALK3 ALK3 ncbigene_synonym bmpr1aa 58145
Danio rerio Vertebrates ALK2 ALK2 ncbigene_synonym acvr1l 30615
Danio rerio Vertebrates Smad2 SMAD2 ncbigene_symbol smad2 30639
Danio rerio Vertebrates Smad2/3 SMAD3 ncbigene_synonym smad3a 58092
Danio rerio Vertebrates Smad1/5/8 SMAD5 ncbigene_symbol smad5 30641
Danio rerio Vertebrates Smad1/5/8 SMAD1 ncbigene_symbol smad1 30628

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID