Pharmokinetic Limitations of Antioxidant Treatment for COPD

TNF binding to TNFR1 stimulates two signaling complexes with opposing effects on cell survival. Complex I (pro-survival) triggers the NF-κB pathway which up regulates the expression of XIAP, a protease that inhibits apoptosis by blocking the caspase signaling cascade. On the other hand, complex II (pro-death) promotes apoptosis by stimulating Fas associated death domain (FADD). This induces apoptosis by stimulating cytochrome c release from the mitochondria and by activating caspases-3, -8 and -10. Cell fate is influenced by the balance of these signaling effects.
Pharmokinetic Limitations of Antioxidant Treatment for COPD
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Publication

The Pharmokinetic Limitations of Antioxidant Treatment for COPD. () Robert Foronjy, et al. Pulm Pharmacol Ther. ;21(2):370-379. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates (TNF TNF ncbigene_symbol TNF 7124
Homo sapiens Primates APP APP ncbigene_symbol APP 351
Homo sapiens Primates IKK IKK famplex_relations CHUK 1147
Homo sapiens Primates IKK IKK famplex_relations IKBKB 3551
Homo sapiens Primates IKK IKK famplex_relations IKBKG 8517
Homo sapiens Primates IKK IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKK IKK famplex_relations TBK1 29110
Homo sapiens Primates (bad BAD ncbigene_symbol BAD 572
Homo sapiens Primates (bid) BID ncbigene_symbol BID 637
Homo sapiens Primates (p50 P50 ncbigene_synonym CD40 958
Homo sapiens Primates (p50 P50 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates (p50 P50 ncbigene_synonym ASCC1 51008
Homo sapiens Primates (p50 P50 ncbigene_synonym H3P40 115482723
Homo sapiens Primates RelA RELA ncbigene_symbol RELA 5970
Homo sapiens Primates XIAP XIAP ncbigene_symbol XIAP 331
Homo sapiens Primates TNF-R1 TNFR1 ncbigene_synonym TNFRSF1A 7132
Homo sapiens Primates TRADD TRADD ncbigene_symbol TRADD 8717
Homo sapiens Primates TRAF2 TRAF2 ncbigene_symbol TRAF2 7186
Homo sapiens Primates TRAF2 TRAF2 ncbigene_synonym TANK 10010
Homo sapiens Primates FADD FADD ncbigene_symbol FADD 8772
Danio rerio Vertebrates (TNF TNF ncbigene_synonym tnfrsfa 114461
Danio rerio Vertebrates (TNF TNF ncbigene_synonym tnfb 554167
Danio rerio Vertebrates APP APP ncbigene_synonym appa 58083
Danio rerio Vertebrates Caspase-8 CASPASE-8 ncbigene_synonym casp8 58022
Danio rerio Vertebrates (bad BAD ncbigene_synonym badb 58100
Danio rerio Vertebrates (bid) BID ncbigene_synonym bida 559425
Danio rerio Vertebrates (p50 P50 ncbigene_synonym nfkb1 565756
Danio rerio Vertebrates RelA RELA ncbigene_symbol rela 415099
Danio rerio Vertebrates XIAP XIAP ncbigene_symbol xiap 373108
Danio rerio Vertebrates TRADD TRADD ncbigene_symbol tradd 58130
Danio rerio Vertebrates FADD FADD ncbigene_symbol fadd 562317

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID