PI3K/AKT signaling pathway activated by 3Alpha-diol
PI3K/AKT signaling pathway activated by 3α-diol. Networks of PI3K/AKT signaling pathway are shown. Genes that are up- or down-regulated by 3α-diol are marked by gradient fill, whereas genes that are not regulated by 3α-diol are marked as gray color. Genes that are not colored indicate the absence of these genes in the membrane array
Publication
5α-androstane-3α,17β-diol selectively activates the canonical PI3K/AKT pathway: a bioinformatics-based evidence for androgen-activated cytoplasmic signaling. (2007) Mikhail G. Dozmorov, et al. Genomic Med. 2007 Sep;1(3-4):139-146. Figure: F3.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | ANGPT1 | 284 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | ANGPT2 | 285 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | ANGPT4 | 51378 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | AREG | 374 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | BDNF | 627 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | CSF1 | 1435 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | EFNA1 | 1942 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | EFNA2 | 1943 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | EFNA3 | 1944 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | EFNA4 | 1945 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | EFNA5 | 1946 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | EGF | 1950 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | EREG | 2069 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF1 | 2246 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF10 | 2255 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF16 | 8823 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF17 | 8822 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF18 | 8817 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF19 | 9965 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF2 | 2247 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF20 | 26281 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF21 | 26291 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF22 | 27006 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF23 | 8074 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF3 | 2248 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF4 | 2249 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF5 | 2250 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF6 | 2251 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF7 | 2252 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF8 | 2253 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FGF9 | 2254 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | FLT3LG | 2323 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | HGF | 3082 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | IGF1 | 3479 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | IGF2 | 3481 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | INS | 3630 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | KITLG | 4254 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | NGF | 4803 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | NTF3 | 4908 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | NTF4 | 4909 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | PDGFA | 5154 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | PDGFB | 5155 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | PDGFC | 56034 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | PDGFD | 80310 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | PGF | 5228 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | TGFA | 7039 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | VEGFA | 7422 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | VEGFB | 7423 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | VEGFC | 7424 |
| Homo sapiens | Primates | Growthfactor | GROWTHFACTOR | famplex_relations | VEGFD | 2277 |
| Homo sapiens | Primates | P13 | P13 | ncbigene_synonym | EXOSC1 | 51013 |
| Homo sapiens | Primates | P13 | P13 | ncbigene_synonym | H3P6 | 440926 |
| Homo sapiens | Primates | JAK | JAK | famplex_relations | JAK1 | 3716 |
| Homo sapiens | Primates | JAK | JAK | famplex_relations | JAK2 | 3717 |
| Homo sapiens | Primates | JAK | JAK | famplex_relations | JAK3 | 3718 |
| Homo sapiens | Primates | JAK | JAK | famplex_relations | TYK2 | 7297 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CA | 5290 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CB | 5291 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CD | 5293 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CG | 5294 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R3 | 8503 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R4 | 30849 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R5 | 23533 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R6 | 146850 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R1 | 5295 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R2 | 5296 |
| Homo sapiens | Primates | SHIP | SHIP | ncbigene_synonym | INPP5D | 3635 |
| Homo sapiens | Primates | PTEN | PTEN | ncbigene_symbol | PTEN | 5728 |
| Homo sapiens | Primates | pes | PES | ncbigene_synonym | PES1 | 23481 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | KRAS | 3845 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | HRAS | 3265 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | NRAS | 4893 |
| Homo sapiens | Primates | ČTMP | CTMP | ncbigene_synonym | THEM4 | 117145 |
| Homo sapiens | Primates | HSP90. | HSP90 | ncbigene_synonym | HSP90AA1 | 3320 |
| Homo sapiens | Primates | HSP90. | HSP90 | famplex_relations | HSP90B1 | 7184 |
| Homo sapiens | Primates | HSP90. | HSP90 | famplex_relations | TRAP1 | 10131 |
| Homo sapiens | Primates | HSP90. | HSP90 | famplex_relations | HSP90AB1 | 3326 |
| Homo sapiens | Primates | Cdc3 | CDC3 | ncbigene_synonym | SEPTIN7 | 989 |
| Homo sapiens | Primates | BAD | BAD | ncbigene_symbol | BAD | 572 |
| Homo sapiens | Primates | Rar | RAR | ncbigene_synonym | RARA | 5914 |
| Homo sapiens | Primates | Rar | RAR | ncbigene_synonym | RAB40B | 10966 |
| Homo sapiens | Primates | Rar | RAR | famplex_relations | RARB | 5915 |
| Homo sapiens | Primates | Rar | RAR | famplex_relations | RARG | 5916 |
| Homo sapiens | Primates | TSC2 | TSC2 | ncbigene_symbol | TSC2 | 7249 |
| Homo sapiens | Primates | MEK1 | MEK1 | ncbigene_synonym | MAP2K1 | 5604 |
| Homo sapiens | Primates | MEK1/2 | MEK2 | ncbigene_synonym | MAP2K2 | 5605 |
| Homo sapiens | Primates | Rheb | RHEB | ncbigene_symbol | RHEB | 6009 |
| Homo sapiens | Primates | Rheb | RHEB | ncbigene_synonym | RHEBP1 | 6008 |
| Homo sapiens | Primates | GYS | GYS | ncbigene_synonym | GYS1 | 2997 |
| Homo sapiens | Primates | GYS | GYS | famplex_relations | GYS2 | 2998 |
| Homo sapiens | Primates | p53 | P53 | ncbigene_synonym | TP53 | 7157 |
| Homo sapiens | Primates | p53 | P53 | famplex_relations | TP63 | 8626 |
| Homo sapiens | Primates | p53 | P53 | famplex_relations | TP73 | 7161 |
| Homo sapiens | Primates | 4E-BP1 | 4E-BP1 | ncbigene_synonym | EIF4EBP1 | 1978 |
| Homo sapiens | Primates | élF4E | EIF4E | ncbigene_symbol | EIF4E | 1977 |
| Homo sapiens | Primates | élF4E | EIF4E | famplex_relations | EIF4E2 | 9470 |
| Homo sapiens | Primates | élF4E | EIF4E | famplex_relations | EIF4E3 | 317649 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT1 | 7471 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT2 | 7472 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT2B | 7482 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT3 | 7473 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT3A | 89780 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT4 | 54361 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT6 | 7475 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT7A | 7476 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT7B | 7477 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT8A | 7478 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT8B | 7479 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT9A | 7483 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT9B | 7484 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT10A | 80326 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT10B | 7480 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT11 | 7481 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT16 | 51384 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT5A | 7474 |
| Homo sapiens | Primates | WNT | WNT | famplex_relations | WNT5B | 81029 |
| Drosophila melanogaster | Invertebrates | PIPE | PIPE | ncbigene_synonym | pip | 40104 |
| Drosophila melanogaster | Invertebrates | P13 | P13 | ncbigene_symbol | P13 | 46285 |
| Drosophila melanogaster | Invertebrates | JAK | JAK | ncbigene_synonym | hop | 32080 |
| Drosophila melanogaster | Invertebrates | JAK | JAK | ncbigene_synonym | bsk | 44801 |
| Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K21B | 33203 |
| Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K59F | 37733 |
| Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K68D | 39329 |
| Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K92E | 42446 |
| Drosophila melanogaster | Invertebrates | PTEN | PTEN | ncbigene_symbol | Pten | 43991 |
| Drosophila melanogaster | Invertebrates | pes | PES | ncbigene_symbol | pes | 34087 |
| Drosophila melanogaster | Invertebrates | Ras | RAS | ncbigene_symbol | ras | 43873 |
| Drosophila melanogaster | Invertebrates | Ras | RAS | ncbigene_synonym | Ras64B | 38494 |
| Drosophila melanogaster | Invertebrates | Ras | RAS | ncbigene_synonym | Ras85D | 41140 |
| Drosophila melanogaster | Invertebrates | ČTMP | TMP | ncbigene_synonym | Smox | 31738 |
| Drosophila melanogaster | Invertebrates | HSP90. | HSP90 | ncbigene_synonym | Hsp83 | 38389 |
| Drosophila melanogaster | Invertebrates | HSP90. | HSP90 | ncbigene_synonym | Gp93 | 43354 |
| Drosophila melanogaster | Invertebrates | DIKK | DIKK | ncbigene_synonym | IKKepsilon | 35329 |
| Drosophila melanogaster | Invertebrates | DIKK | DIKK | ncbigene_synonym | key | 37967 |
| Drosophila melanogaster | Invertebrates | DIKK | DIKK | ncbigene_synonym | IKKbeta | 44432 |
| Drosophila melanogaster | Invertebrates | BAD | BAD | ncbigene_synonym | cass | 35053 |
| Drosophila melanogaster | Invertebrates | TSC2 | TSC2 | ncbigene_synonym | gig | 40201 |
| Drosophila melanogaster | Invertebrates | MEK1/2 | MEK1/2 | ncbigene_synonym | Dsor1 | 31872 |
| Drosophila melanogaster | Invertebrates | Rheb | RHEB | ncbigene_symbol | Rheb | 117332 |
| Drosophila melanogaster | Invertebrates | GYS | GYS | ncbigene_synonym | GlyS | 41823 |
| Drosophila melanogaster | Invertebrates | p53 | P53 | ncbigene_symbol | p53 | 2768677 |
| Drosophila melanogaster | Invertebrates | p53 | P53 | ncbigene_synonym | betaTub60D | 37888 |
| Drosophila melanogaster | Invertebrates | p53 | P53 | ncbigene_synonym | hth | 41273 |
| Drosophila melanogaster | Invertebrates | 4E-BP1 | 4E-BP1 | ncbigene_synonym | Thor | 33569 |
| Drosophila melanogaster | Invertebrates | élF4E | ELF4E | ncbigene_synonym | eIF4E1 | 45525 |
| Drosophila melanogaster | Invertebrates | élF4E | EIF4E | ncbigene_synonym | eIF4E7 | 31059 |
| Drosophila melanogaster | Invertebrates | élF4E | EIF4E | ncbigene_synonym | eIF4E4 | 38743 |
| Drosophila melanogaster | Invertebrates | élF4E | EIF4E | ncbigene_synonym | eIF4E5 | 38878 |
| Drosophila melanogaster | Invertebrates | élF4E | EIF4E | ncbigene_synonym | eIF4E3 | 38923 |
| Drosophila melanogaster | Invertebrates | élF4E | EIF4E | ncbigene_synonym | eIF4E6 | 43422 |
| Drosophila melanogaster | Invertebrates | élF4E | EIF4E | ncbigene_synonym | eIF4EHP | 326255 |
| Drosophila melanogaster | Invertebrates | cycle | CYCLE | ncbigene_synonym | CycE | 34924 |
| Drosophila melanogaster | Invertebrates | cycle | CYCLE | ncbigene_synonym | cyc | 40162 |
| Drosophila melanogaster | Invertebrates | WNT | WNT | ncbigene_synonym | Wnt5 | 32838 |
| Drosophila melanogaster | Invertebrates | WNT | WNT | ncbigene_synonym | Wnt4 | 34007 |
| Drosophila melanogaster | Invertebrates | WNT | WNT | ncbigene_synonym | wg | 34009 |
| Drosophila melanogaster | Invertebrates | WNT | WNT | ncbigene_synonym | Wnt2 | 35975 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| Cancer | NA | |||
| Lung cancer | NA |