Idiopathic Pulmonary Fibrosis: Aberrant Recapitulation of Developmental Programs?

In IPF lungs, TGF-β3, gremlin, and LEF-1 are up-regulated, while BMP-2 is down-regulated. Dysregulation of TGF-β/BMP pathway induces a fibrotic phenotype. EMT, so important in development, is likely to represent one possible response of the alveolar epithelial cell facing sustained injury. Increased expression of BMPs may not only antagonize TGF-β-induced EMT, enhancing re-epithelialization, but also may cause the opposite process, mesenchymal-to-epithelial transition (MET).
Idiopathic Pulmonary Fibrosis: Aberrant Recapitulation of Developmental Programs?
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

Idiopathic Pulmonary Fibrosis: Aberrant Recapitulation of Developmental Programs?. (2008) Moisés Selman, et al. PLoS Med. 2008 Mar;5(3):e62. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates BMP BMP famplex_relations BMP1 649
Homo sapiens Primates BMP BMP famplex_relations BMP2 650
Homo sapiens Primates BMP BMP famplex_relations BMP3 651
Homo sapiens Primates BMP BMP famplex_relations BMP4 652
Homo sapiens Primates BMP BMP famplex_relations BMP5 653
Homo sapiens Primates BMP BMP famplex_relations BMP6 654
Homo sapiens Primates BMP BMP famplex_relations BMP7 655
Homo sapiens Primates BMP BMP famplex_relations BMP8A 353500
Homo sapiens Primates BMP BMP famplex_relations BMP8B 656
Homo sapiens Primates BMP BMP famplex_relations BMP10 27302
Homo sapiens Primates BMP BMP famplex_relations BMP15 9210
Homo sapiens Primates BMP BMP famplex_relations GDF1 2657
Homo sapiens Primates BMP BMP famplex_relations GDF2 2658
Homo sapiens Primates BMP BMP famplex_relations GDF3 9573
Homo sapiens Primates BMP BMP famplex_relations GDF5 8200
Homo sapiens Primates BMP BMP famplex_relations GDF6 392255
Homo sapiens Primates BMP BMP famplex_relations GDF7 151449
Homo sapiens Primates TGF-B TGFB ncbigene_synonym TGFB1 7040
Homo sapiens Primates TGF-B TGFB famplex_relations TGFB2 7042
Homo sapiens Primates TGF-B TGFB famplex_relations TGFB3 7043
Homo sapiens Primates Gremlin GREMLIN ncbigene_synonym GREM1 26585
Homo sapiens Primates BMPR-1A, BMPR-1A ncbigene_synonym BMPR1A 657
Homo sapiens Primates тBR-I BRI ncbigene_synonym ITM2B 9445
Homo sapiens Primates ВМPR-П MPR ncbigene_synonym PGRMC1 10857
Homo sapiens Primates Smad2 SMAD2 ncbigene_symbol SMAD2 4087
Homo sapiens Primates Smadl SMAD1 ncbigene_symbol SMAD1 4086
Homo sapiens Primates Smadl SMAD1 ncbigene_synonym GARS1 2617
Homo sapiens Primates Smad5 SMAD5 ncbigene_symbol SMAD5 4090
Homo sapiens Primates Smad8 SMAD8 ncbigene_synonym SMAD9 4093
Homo sapiens Primates Smad3 SMAD3 ncbigene_symbol SMAD3 4088
Homo sapiens Primates Smad4 SMAD4 ncbigene_symbol SMAD4 4089
Homo sapiens Primates LEF-1 LEF-1 ncbigene_synonym LEF1 51176
Homo sapiens Primates EMT EMT ncbigene_synonym ITK 3702
Homo sapiens Primates EMT EMT ncbigene_synonym SLC22A3 6581
Danio rerio Vertebrates BMPR-1A, BMPR1A ncbigene_synonym bmpr1aa 58145
Danio rerio Vertebrates BMPR-1A,B BMPR1AB ncbigene_symbol bmpr1ab 447846
Danio rerio Vertebrates BMPR-1A,B BMPR1B ncbigene_synonym bmpr1ba 30742
Danio rerio Vertebrates Smad2 SMAD2 ncbigene_symbol smad2 30639
Danio rerio Vertebrates Smadl SMAD1 ncbigene_symbol smad1 30628
Danio rerio Vertebrates Smad5 SMAD5 ncbigene_symbol smad5 30641
Danio rerio Vertebrates Smad3 SMAD3 ncbigene_synonym smad3a 58092
Danio rerio Vertebrates Smad4 SMAD4 ncbigene_synonym smad4a 559111
Danio rerio Vertebrates Smad4 SMAD4 ncbigene_synonym smad4b 794669
Danio rerio Vertebrates LEF-1 LEF1 ncbigene_symbol lef1 30701

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID