Metabolic pathways involved in pyrimidine metabolism

Metabolic pathways involved in pyrimidine metabolism. Uridine replenishes all pyrimidines distal from DHODH. Gray boxes indicate RNA and DNA building blocks. Based on the Kyoto Encyclopedia of Genes and Genomes reference pathway for pyrimidine metabolism (Accessed February 2007, http://www.genome.jp/kegg/pathway/map/map00240.html).
Metabolic pathways involved in pyrimidine metabolism
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Publication

Pyrimidine Nucleoside Depletion Sensitizes to the Mitochondrial Hepatotoxicity of the Reverse Transcriptase Inhibitor Stavudine. (2008) Bernhard Setzer, et al. Am J Pathol. 2008 Mar;172(3):681-690. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates DHODH DHODH ncbigene_symbol DHODH 1723
Homo sapiens Primates UMPS UMPS ncbigene_symbol UMPS 7372
Homo sapiens Primates CMP CMP ncbigene_synonym MATN1 4146
Homo sapiens Primates CTP CTP ncbigene_synonym SLC25A1 6576
Homo sapiens Primates CDP CDP ncbigene_synonym CUX1 1523
Homo sapiens Primates CDP CDP ncbigene_synonym NPPA 4878
Homo sapiens Primates DHFR DHFR ncbigene_symbol DHFR 1719
Homo sapiens Primates UCK2 UCK2 ncbigene_symbol UCK2 7371
Drosophila melanogaster Invertebrates DHODH DHODH ncbigene_synonym Dhod 41022
Drosophila melanogaster Invertebrates UMPS UMPS ncbigene_synonym r-l 42493
Drosophila melanogaster Invertebrates CMP CMP ncbigene_symbol cmp 248126
Drosophila melanogaster Invertebrates CTP CTP ncbigene_symbol ctp 31405
Drosophila melanogaster Invertebrates DHFR DHFR ncbigene_symbol Dhfr 42003
Drosophila melanogaster Invertebrates UCK2 UCK2 ncbigene_synonym Uck 42894
Drosophila melanogaster Invertebrates ĐCK CK ncbigene_symbol ck 34882

Chemical mentions

Word Match MeSH Name ChEBI
Cytidine Cytidine mesh:D003562 cytidine chebi:17562
CDP Cytidine Diphosphate mesh:D003565 CDP chebi:17239
CMP Cytidine Monophosphate mesh:D003568 cytidine 5'-monophosphate chebi:17361
Cytosine Cytosine mesh:D003596 cytosine chebi:16040
Thymidine Thymidine mesh:D013936 thymidine chebi:17748
Thymine Thymine mesh:D013941 thymine chebi:17821
Uracil Uracil mesh:D014498 uracil chebi:17568
Uridine Uridine mesh:D014529 uridine chebi:16704
UDP Uridine Diphosphate mesh:D014530 UDP chebi:17659
UTP Uridine Triphosphate mesh:D014544 UTP chebi:15713
Stavudine Stavudine mesh:D018119 stavudine chebi:63581

Disease mentions

Word Match MeSH Name DOID