A simplified diagram of the link between glycolysis and the pentose phosphate pathway
A simplified diagram of the link between glycolysis and the pentose phosphate pathway. The pentose phosphate pathway is linked to glycolysis through glucose 6-phosphate; if it is oxidized, it enters the pentose phosphate pathway, whereas if it is isomerized to fructose-6-phosphate, it continues through glycolysis. Inhibiting glycolysis through alterations in the activity of TPI or GAPDH redirects the metabolic flux towards the pentose phosphate pathway and generation of NADPH. Abbreviations: 6PG, 6-phosphogluconate; 6PGDH, 6-phosphogluconate dehydrogenase; DHAP, dihydroxyacetone phosphate; G6PDH, glucose 6-phosphate dehydrogenase; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; P, phosphate; R5P, ribulose 5-phosphate; TPI, triosephosphate isomerase.
Publication
Metabolic reconfiguration is a regulated response to oxidative stress. (2008) Chris M Grant. J Biol. 2008;7(1):1-1. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | 6PGDH | 6PGDH | ncbigene_synonym | Pgd | 31185 |
| Drosophila melanogaster | Invertebrates | G6PDH | G6PDH | ncbigene_synonym | Zw | 32974 |
| Drosophila melanogaster | Invertebrates | DHAP | DHAP | ncbigene_synonym | Aldh-III | 45398 |
| Drosophila melanogaster | Invertebrates | TPI | TPI | ncbigene_symbol | Tpi | 43582 |
| Drosophila melanogaster | Invertebrates | GAPDH | GAPDH | ncbigene_synonym | Gapdh2 | 32545 |
| Drosophila melanogaster | Invertebrates | GAPDH | GAPDH | ncbigene_synonym | Gpdh1 | 33824 |
| Drosophila melanogaster | Invertebrates | GAPDH | GAPDH | ncbigene_synonym | Gapdh1 | 35728 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| 1,3-Bisphosphoglycerate | NA | mesh:C015891 | ||
| Fructose-1,6-P | Fructose | mesh:D005632 | fructose | chebi:28757 |
| Fructose-6-P | Fructose | mesh:D005632 | fructose | chebi:28757 |
| Glucose | Glucose | mesh:D005947 | D-glucopyranose | chebi:4167 |
| Glyceraldehyde-3-P | Glyceraldehyde | mesh:D005985 | glyceraldehyde | chebi:5445 |
| Pentose phosphate | Pentoses | mesh:D010429 | pentose | chebi:25901 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|