Proposed metabolic pathway for PSI-6130
Proposed metabolic pathway for PSI-6130. The kinetic values for the phosphorylation of PSI-6130, PSI-6130-MP, and PSI-6130-DP are from previously published data ().
Publication
The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase . (2008) Eisuke Murakami, et al. Antimicrob Agents Chemother. 2008 Feb;52(2):458-464. Figure: F3.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | dCK | DCK | ncbigene_symbol | DCK | 1633 |
| Homo sapiens | Primates | Ms | MS | ncbigene_symbol | MS | 4397 |
| Homo sapiens | Primates | uMs | UMS | ncbigene_synonym | TBX3 | 6926 |
| Homo sapiens | Primates | CDA | CDA | ncbigene_symbol | CDA | 978 |
| Homo sapiens | Primates | DCTD | DCTD | ncbigene_symbol | DCTD | 1635 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| PSI-6130-DP | NA | mesh:C504520 | ||
| PSI-6130-MP | NA | mesh:C504520 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|