Gluten affects epithelial differentiation-associated genes in small intestinal mucosa of coeliac patients

Schematic illustration of mRNA expression levels significantly altered both in duodenal biopsy samples from untreated coeliac disease patients and in undifferentiated epithelial T84 cells in the epithelial cell differentiation model. Expression levels of epidermal growth factor receptor (EGFR), related to the N terminus of tre (RN-tre), ephrin B2, Wiskott–Aldrich syndrome protein family member 1 (WAVE1), diacylglycerol kinase D (DGKD), phosphoinositide-3-kinase regulatory subunit 1 (PI3KR1), fused toes homologue (FTS), mature T cell proliferation (MTCP1) and β-catenin were increased in untreated coeliac disease and in undifferentiated cell culture samples. Red colour indicates a significant up-regulation of mRNA expression both in duodenal biopsy samples and in the epithelial cell differentiation model. White indicates genes not mutually altered. Yellow circles indicate the outcome of the pathway. The figure was drawn according to the Kyoto encyclopedia of genes and genomes (KEGG) (http://www.genome.jp/dbget-bin/).

Publication

Gluten affects epithelial differentiation-associated genes in small intestinal mucosa of coeliac patients. (2007) K Juuti-Uusitalo, et al. Clin Exp Immunol. 2007 Nov;150(2):294-305. Figure: F1. All organisms Homo sapiens Drosophila melanogaster

Disease mentions