Regulatory networks sensitive to tyrosine kinase inhibitors in H3255 and MKN45 cells revealed by PhosphpScan-SILAC study

Regulatory networks sensitive to tyrosine kinase inhibitors in H3255 and MKN45 cells revealed by PhosphpScan-SILAC study. (A) Core signaling molecules inhibited by both gefitinib in H3255 cells and Su11274 in MKN45 cells. The proteins indicated show at least one phosphotyrosine site reduced >2.5-fold at 3 h of drug treatment. Signaling pathway connections are from PhosphoSite (), with additional protein–protein interactions extracted from PROTEOME. (B) RTK networks revealed by PhosphoScan-SILAC in MKN45 cells (Left). Receptor tyrosine kinase activation loop tyrosine sites inhibited by Su11274 in MKN45 cells (Right). (C) RTK networks revealed by PhosphoScan-SILAC in H3255 cells. In B and C, WB indicates the sites identified by Western blot analysis. All other sites are from PhosphoScan-SILAC study. Solid arrow, known interaction; dashed arrow, predicted interaction.

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Signaling networks assembled by oncogenic EGFR and c-Met. (2008) Ailan Guo, et al. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):692-697. Figure: F4. All organisms Drosophila melanogaster Homo sapiens

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