Checkpoints activated upon rereplication

Checkpoints activated upon rereplication. Multiple rounds of replication could give rise to replication origins within replication bubbles which would activate ATR-dependent signaling pathways. Replication fork collision could generate DNA double strand breaks and activate ATM-dependent pathways. Orange stars denote proteins essential for checkpoint activation in response to rereplication. The pink dashed line denotes a hypothetical pathway. The 9-1-1 complex is composed of Rad9-Rad1-Hus1. The MRN complex is made up of Mre11-Rad50-Nbs1.
Checkpoints activated upon rereplication
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Publication

Mechanisms to Control Rereplication and Implications for Cancer. () Sara S. Hook, et al. Curr Opin Cell Biol. ;19(6):663-671. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents Rad17/RFC RFC ncbigene_synonym Slc19a1 20509
Mus musculus Rodents Rad17/RFC RAD17 ncbigene_symbol Rad17 19356
Mus musculus Rodents ATR ATR ncbigene_symbol Atr 245000
Mus musculus Rodents ATR ATR ncbigene_synonym Mmab 77697
Mus musculus Rodents BRCA1 BRCA1 ncbigene_symbol Brca1 12189
Mus musculus Rodents ATM ATM ncbigene_symbol Atm 11920
Mus musculus Rodents ATM ATM ncbigene_synonym Tpm1 22003
Mus musculus Rodents FA FA ncbigene_symbol fa 14072
Mus musculus Rodents Chk1 CHK1 ncbigene_synonym Chek1 12649
Mus musculus Rodents Chk2 CHK2 ncbigene_synonym Chek2 50883
Mus musculus Rodents p53 P53 ncbigene_synonym Trp53 22059
Mus musculus Rodents FANCD2 FANCD2 ncbigene_symbol Fancd2 211651
Mus musculus Rodents Cdc25C CDC25C ncbigene_symbol Cdc25c 12532
Mus musculus Rodents p21 P21 ncbigene_synonym Cdkn1a 12575
Mus musculus Rodents p21 P21 ncbigene_synonym Nsg1 18196
Mus musculus Rodents p21 P21 ncbigene_synonym Tpt1 22070
Mus musculus Rodents p21 P21 ncbigene_synonym Tceal1 237052
Mus musculus Rodents Cdk2 CDK2 ncbigene_symbol Cdk2 12566
Mus musculus Rodents Cdk1 CDK1 ncbigene_symbol Cdk1 12534
Mus musculus Rodents ATRIP ATRIP ncbigene_symbol Atrip 235610
Homo sapiens Primates Rad17/RFC RFC ncbigene_synonym RFC1 5981
Homo sapiens Primates Rad17/RFC RFC ncbigene_synonym SLC19A1 6573
Homo sapiens Primates Rad17/RFC RFC famplex_relations RFC2 5982
Homo sapiens Primates Rad17/RFC RFC famplex_relations RFC3 5983
Homo sapiens Primates Rad17/RFC RFC famplex_relations RFC4 5984
Homo sapiens Primates Rad17/RFC RFC famplex_relations RFC5 5985
Homo sapiens Primates Rad17/RFC RAD17 ncbigene_symbol RAD17 5884
Homo sapiens Primates ATR ATR ncbigene_symbol ATR 545
Homo sapiens Primates ATR ATR ncbigene_synonym ANTXR1 84168
Homo sapiens Primates ATR ATR ncbigene_synonym MMAB 326625
Homo sapiens Primates ATR ATR ncbigene_synonym SERPINA2 390502
Homo sapiens Primates BRCA1 BRCA1 ncbigene_symbol BRCA1 672
Homo sapiens Primates MRN MRN famplex_relations MRE11 4361
Homo sapiens Primates MRN MRN famplex_relations NBN 4683
Homo sapiens Primates MRN MRN famplex_relations RAD50 10111
Homo sapiens Primates MRN MRN famplex_relations WDCP 80304
Homo sapiens Primates ATM ATM ncbigene_symbol ATM 472
Homo sapiens Primates Chk1 CHK1 ncbigene_synonym CHEK1 1111
Homo sapiens Primates Chk2 CHK2 ncbigene_synonym CHEK2 11200
Homo sapiens Primates p53 P53 ncbigene_synonym TP53 7157
Homo sapiens Primates p53 P53 famplex_relations TP63 8626
Homo sapiens Primates p53 P53 famplex_relations TP73 7161
Homo sapiens Primates FANCD2 FANCD2 ncbigene_symbol FANCD2 2177
Homo sapiens Primates Cdc25C CDC25C ncbigene_symbol CDC25C 995
Homo sapiens Primates p21 P21 ncbigene_synonym CDKN1A 1026
Homo sapiens Primates p21 P21 ncbigene_synonym TCEAL1 9338
Homo sapiens Primates p21 P21 ncbigene_synonym NSG1 27065
Homo sapiens Primates p21 P21 ncbigene_synonym H3P16 644914
Homo sapiens Primates Cdk2 CDK2 ncbigene_symbol CDK2 1017
Homo sapiens Primates Cdk1 CDK1 ncbigene_symbol CDK1 983
Homo sapiens Primates ATRIP ATRIP ncbigene_symbol ATRIP 84126
Drosophila melanogaster Invertebrates double DOUBLE ncbigene_symbol double 248382
Drosophila melanogaster Invertebrates Rad17/RFC RFC ncbigene_symbol Rf-c 5657049
Drosophila melanogaster Invertebrates Rad17/RFC RFC ncbigene_synonym CG8142 32763
Drosophila melanogaster Invertebrates Rad17/RFC RFC ncbigene_synonym RfC4 38492
Drosophila melanogaster Invertebrates Rad17/RFC RFC ncbigene_synonym Gnf1 40607
Drosophila melanogaster Invertebrates Rad17/RFC RAD17 ncbigene_symbol Rad17 41779
Drosophila melanogaster Invertebrates ATR ATR ncbigene_synonym mei-41 32608
Drosophila melanogaster Invertebrates ATR ATR ncbigene_synonym put 41772
Drosophila melanogaster Invertebrates ATR ATR ncbigene_synonym RYa-R 43253
Drosophila melanogaster Invertebrates MRN MRN ncbigene_symbol mrn 39688
Drosophila melanogaster Invertebrates ATM ATM ncbigene_synonym tefu 41839
Drosophila melanogaster Invertebrates Chk1 CHK1 ncbigene_synonym grp 34993
Drosophila melanogaster Invertebrates Chk2 CHK2 ncbigene_synonym lok 35288
Drosophila melanogaster Invertebrates p53 P53 ncbigene_symbol p53 2768677
Drosophila melanogaster Invertebrates p53 P53 ncbigene_synonym betaTub60D 37888
Drosophila melanogaster Invertebrates p53 P53 ncbigene_synonym hth 41273
Drosophila melanogaster Invertebrates FANCD2 FANCD2 ncbigene_symbol Fancd2 2768674
Drosophila melanogaster Invertebrates Cdc25C CDC25C ncbigene_synonym stg 43466
Drosophila melanogaster Invertebrates p21 P21 ncbigene_synonym dap 36001
Drosophila melanogaster Invertebrates Cdk2 CDK2 ncbigene_symbol Cdk2 42453
Drosophila melanogaster Invertebrates Cdk1 CDK1 ncbigene_symbol Cdk1 34411
Drosophila melanogaster Invertebrates ATRIP ATRIP ncbigene_synonym mus304 40003

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID