Calcium-independent microtubule-dependent pathway is required for FcɛRI-mediated degranulation in mast cells
Calcium-independent microtubule-dependent pathway is required for FcɛRI-mediated degranulation in mast cells. The FcɛRI-mediated signaling pathway can be dissected into calcium-dependent and calcium-independent pathways. The calcium-independent pathway is critical for microtubule-dependent translocation of granules to the plasma membrane, and this pathway is regulated by Fyn/Gab2/RhoA signaling.
Publication
FcɛRI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. (2005) Keigo Nishida, et al. J Cell Biol. 2005 Jul 4;170(1):115-126. Figure: F7.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | FC:RI | FCRI | ncbigene_synonym | FCGR1A | 2209 |
| Homo sapiens | Primates | FC:RI | FCRI | ncbigene_synonym | FCGR1BP | 2210 |
| Homo sapiens | Primates | Lyn | LYN | ncbigene_symbol | LYN | 4067 |
| Homo sapiens | Primates | Fyn | FYN | ncbigene_symbol | FYN | 2534 |
| Homo sapiens | Primates | Gab2 | GAB2 | ncbigene_symbol | GAB2 | 9846 |
| Homo sapiens | Primates | RhoA | RHOA | ncbigene_symbol | RHOA | 387 |
| Homo sapiens | Primates | SNARE | SNARE | ncbigene_symbol | SNAR-E | 100170220 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|