LPS signals the TLR4 pathway on an APC (i.e., monocyte or dendritic cell)

LPS signals the TLR4 pathway on an APC (i.e., monocyte or dendritic cell). TLR4 is a pathogen-associated receptor for Gram-negative bacterial product LPS.TLR4 requires MD-2, a secreted molecule, to functionally interact with the LPS:LPS binding protein complex (LPB). CD14 stabilizes and enhances LPS signaling. TLR4 engagement of LPS leads to nuclear factor-κB translocation via MyD88-dependent and MyD88-independent pathway that involve the TIR domain–ontaining adapter protein TIRAP. Adapted by permission from MacMillan Publisher Ltd: Nature Immunology 4; 1144–1150; Copyright 2003.
LPS signals the TLR4 pathway on an APC (i.e., monocyte or dendritic cell)
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Publication

Toll-like Receptors in Tumor Immunotherapy. () Chrystal M. Paulos, et al. Clin Cancer Res. ;13(18 Pt 1):5280-5289. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates LPS LPS ncbigene_synonym IRF6 3664
Homo sapiens Primates LBP LBP ncbigene_symbol LBP 3929
Homo sapiens Primates LBP LBP ncbigene_synonym EHHADH 1962
Homo sapiens Primates LBP LBP ncbigene_synonym RPSA 3921
Homo sapiens Primates TLR4 TLR4 ncbigene_symbol TLR4 7099
Homo sapiens Primates CD14 CD14 ncbigene_symbol CD14 929
Homo sapiens Primates CD14 CD14 ncbigene_synonym NDUFA2 4695
Homo sapiens Primates MD2 MD2 ncbigene_synonym LY96 23643
Homo sapiens Primates TRAM TRAM ncbigene_synonym TRAM1 23471
Homo sapiens Primates TRAM TRAM ncbigene_synonym TICAM2 353376
Homo sapiens Primates TRAM TRAM ncbigene_synonym TMED7-TICAM2 100302736
Homo sapiens Primates TIRAP TIRAP ncbigene_symbol TIRAP 114609
Homo sapiens Primates MYD88 MYD88 ncbigene_symbol MYD88 4615
Homo sapiens Primates TRIF TRIF ncbigene_synonym TRIM69 140691
Homo sapiens Primates TRIF TRIF ncbigene_synonym TICAM1 148022
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Mus musculus Rodents LPS LPS ncbigene_synonym Tlr4 21898
Mus musculus Rodents LBP LBP ncbigene_symbol Lbp 16803
Mus musculus Rodents LBP LBP ncbigene_synonym Ehhadh 74147
Mus musculus Rodents CD14 CD14 ncbigene_symbol Cd14 12475
Mus musculus Rodents MD2 MD2 ncbigene_synonym Ly96 17087
Mus musculus Rodents TRAM TRAM ncbigene_synonym Tmed7 66676
Mus musculus Rodents TRAM TRAM ncbigene_synonym Ticam2 225471
Mus musculus Rodents TIRAP TIRAP ncbigene_symbol Tirap 117149
Mus musculus Rodents MYD88 MYD88 ncbigene_symbol Myd88 17874
Mus musculus Rodents TRIF TRIF ncbigene_synonym Rnf138 56515
Mus musculus Rodents TRIF TRIF ncbigene_synonym Trim69 70928
Mus musculus Rodents TRIF TRIF ncbigene_synonym Ticam1 106759
Mus musculus Rodents NF-KB NF-KB ncbigene_synonym Nfkb1 18033
Drosophila melanogaster Invertebrates LBP LBP ncbigene_synonym Mtpalpha 34276
Drosophila melanogaster Invertebrates TLR4 TLR4 ncbigene_synonym Toll-4 34235
Drosophila melanogaster Invertebrates TRAM TRAM ncbigene_symbol TRAM 31042
Drosophila melanogaster Invertebrates MYD88 MYD88 ncbigene_symbol Myd88 35956
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym Dif 35045
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym dl 35047
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym Rel 41087
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Drosophila melanogaster Invertebrates CCR CCR ncbigene_synonym Cpr 33883

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID