Promiscuous Mutations Activate the Non-Canonical NF-kB Pathway in Multiple Myeloma

The genes with inactivating abnormalities; TRAF2, TRAF3, cIAP1, cIAP2, and CYLD, are indicated by green objects while the genes with activating abnormalities; LTBR, TACI, CD40, NIK, and NFKB2, are indicated by red objects. Based on our observations and those from other groups we propose the existence of a cytoplasmic NIK regulatory complex, shown in the light red hexagon, that is dependent on TRAF2, TRAF3, cIAP1 and/or cIAP2.
Promiscuous Mutations Activate the Non-Canonical NF-kB Pathway in Multiple Myeloma
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Promiscuous Mutations Activate the Non-Canonical NF-kB Pathway in Multiple Myeloma. () Jonathan J. Keats, et al. Cancer Cell. ;12(2):131-144. Figure: F6.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates APRIL APRIL ncbigene_synonym TNFSF13 8741
Homo sapiens Primates APRIL APRIL ncbigene_synonym ANP32B 10541
Homo sapiens Primates BAFF BAFF ncbigene_synonym TNFSF13B 10673
Homo sapiens Primates TACI TACI ncbigene_synonym TNFRSF13B 23495
Homo sapiens Primates LTB LTB ncbigene_symbol LTB 4050
Homo sapiens Primates LTBR LTBR ncbigene_symbol LTBR 4055
Homo sapiens Primates Ciap2 CIAP2 ncbigene_synonym BIRC3 330
Homo sapiens Primates (TRAF3 TRAF3 ncbigene_symbol TRAF3 7187
Homo sapiens Primates Ciap1 CIAP1 ncbigene_synonym BIRC2 329
Homo sapiens Primates TRAF2 TRAF2 ncbigene_symbol TRAF2 7186
Homo sapiens Primates TRAF2 TRAF2 ncbigene_synonym TANK 10010
Homo sapiens Primates IKKY IKKG ncbigene_synonym IKBKG 8517
Homo sapiens Primates CYLD CYLD ncbigene_symbol CYLD 1540
Homo sapiens Primates IKKB) IKKB ncbigene_synonym IKBKB 3551
Homo sapiens Primates IKKA IKKA ncbigene_synonym CHUK 1147
Homo sapiens Primates TAB2 TAB2 ncbigene_symbol TAB2 23118
Homo sapiens Primates NFKB1 NFKB1 ncbigene_symbol NFKB1 4790
Homo sapiens Primates NFKB1 NFKB1 famplex_relations NFKB2 4791
Homo sapiens Primates (p105) P105 ncbigene_synonym CDH13 1012
Homo sapiens Primates (p105) P105 ncbigene_synonym SCYL1 57410
Homo sapiens Primates (p100) P100 ncbigene_synonym CUX1 1523
Homo sapiens Primates (p100) P100 ncbigene_synonym OAS3 4940
Homo sapiens Primates (p100) P100 ncbigene_synonym PMEL 6490
Homo sapiens Primates (p100) P100 ncbigene_synonym SART3 9733
Homo sapiens Primates (p100) P100 ncbigene_synonym TPX2 22974
Homo sapiens Primates (p100) P100 ncbigene_synonym SND1 27044
Homo sapiens Primates (p100) P100 ncbigene_synonym ASCC2 84164
Homo sapiens Primates NFKB2 NFKB2 famplex_relations RELA 5970
Homo sapiens Primates NFKB2 NFKB2 famplex_relations RELB 5971
Homo sapiens Primates NFKB2 NFKB2 famplex_relations REL 5966
Homo sapiens Primates REL/p65 P65 ncbigene_synonym SYT1 6857
Homo sapiens Primates REL/p65 P65 ncbigene_synonym GORASP1 64689
Homo sapiens Primates REL/p65 P65 ncbigene_synonym WNK1 65125
Homo sapiens Primates NIK) NIK ncbigene_synonym MAP3K14 9020
Homo sapiens Primates NIK) NIK ncbigene_synonym MAP4K4 9448
Homo sapiens Primates p50 P50 ncbigene_synonym CD40 958
Homo sapiens Primates p50 P50 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates p50 P50 ncbigene_synonym ASCC1 51008
Homo sapiens Primates p50 P50 ncbigene_synonym H3P40 115482723
Homo sapiens Primates B-TrCP B-TRCP ncbigene_synonym BTRC 8945
Homo sapiens Primates p52 P52 ncbigene_synonym FKBP4 2288
Homo sapiens Primates p52 P52 ncbigene_synonym GTF2H4 2968
Homo sapiens Primates p52 P52 ncbigene_synonym PMPCB 9512
Homo sapiens Primates p52 P52 ncbigene_synonym PSIP1 11168
Homo sapiens Primates p52 P52 ncbigene_synonym H3P42 115482704
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA1 5682
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA2 5683
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA3 5684
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA4 5685
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA5 5686
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA6 5687
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA7 5688
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA8 143471
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB1 5689
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB10 5699
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB2 5690
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB3 5691
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB4 5692
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB5 5693
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB6 5694
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB7 5695
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB8 5696
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB9 5698
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC1 5700
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC2 5701
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC3 5702
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC4 5704
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC5 5705
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC6 5706
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD1 5707
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD10 5716
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD11 5717
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD12 5718
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD13 5719
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD14 10213
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD2 5708
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD3 5709
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD4 5710
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD5 5711
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD6 9861
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD7 5713
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD8 5714
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD9 5715
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSME1 5720
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSME2 5721
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSME3 10197
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMF1 9491
Homo sapiens Primates Proteasome PROTEASOME famplex_relations SEM1 7979
Homo sapiens Primates Proteasome PROTEASOME famplex_relations USP5 8078
Homo sapiens Primates BCL3 BCL3 ncbigene_symbol BCL3 602
Danio rerio Vertebrates APRIL APRIL ncbigene_synonym tnfsf13 100149404
Danio rerio Vertebrates (TRAF3 TRAF3 ncbigene_symbol traf3 445119
Danio rerio Vertebrates CYLD CYLD ncbigene_synonym cylda 556823
Danio rerio Vertebrates TAB2 TAB2 ncbigene_symbol tab2 494163
Danio rerio Vertebrates NFKB1 NFKB1 ncbigene_symbol nfkb1 565756
Danio rerio Vertebrates (p100) P100 ncbigene_synonym nfkb2 415100
Danio rerio Vertebrates RELB RELB ncbigene_symbol relb 795414
Danio rerio Vertebrates REL/p65 P65 ncbigene_synonym rela 415099
Danio rerio Vertebrates REL/p65 REL ncbigene_symbol rel 415101
Danio rerio Vertebrates BCL3 BCL3 ncbigene_symbol bcl3 565656

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID