PTEN/PI3K/mTOR/STAT3 signaling involved in breast cancer stem-like cell survival and proliferation

Schematic representation of PTEN/PI3K/mTOR/STAT3 signaling involved in breast cancer stem-like cell survival and proliferation. Arrows indicate activation, and bars indicate inhibition.
PTEN/PI3K/mTOR/STAT3 signaling involved in breast cancer stem-like cell survival and proliferation
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. (2007) Jiangbing Zhou, et al. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16158-16163. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates IS3 IS3 ncbigene_synonym CHD7 55636
Homo sapiens Primates mTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates STAT3 STAT3 ncbigene_symbol STAT3 6774
Mus musculus Rodents PI3K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents PTEN PTEN ncbigene_symbol Pten 19211
Mus musculus Rodents AKT AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents mTOR MTOR ncbigene_symbol Mtor 56717
Mus musculus Rodents STAT3 STAT3 ncbigene_symbol Stat3 20848
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates mTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates mTOR MTOR ncbigene_synonym Tor 47396

Chemical mentions

Word Match MeSH Name ChEBI
LY294002 NA mesh:C085911
Rapamycin Sirolimus mesh:D020123 sirolimus chebi:9168

Disease mentions

Word Match MeSH Name DOID