The G12/13 signaling pathway

The G12/13 signaling pathway. Rho-GEF activities involve their DHPH domains. DH, Dbl-domain; PH, PH domain; BM, Btk domain; Y, Tyrpsine; pY, phosphotyrosine. G12α and Gβγ are shown as activators of the Tec kinases Tec and Btk. The interaction has been shown to involve the PHBM domain of the Tec kinase (Tsukada et al., 1994 []; Langhans-Rajasekaran et al., 1995 []; Jiang et al., 1998 []).
The G12/13 signaling pathway
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Publication

Expansion of signal transduction by G proteins The second 15 years or so: From 3 to 16 α subunits plus βγ dimers. () Lutz Birnbaumer. Biochim Biophys Acta. ;1768(4):772-793. Figure: F13.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates p115-RhoGEF P115-RHOGEF ncbigene_synonym ARHGEF1 9138
Homo sapiens Primates GPCR GPCR ncbigene_synonym FZD4 8322
Homo sapiens Primates GPCR GPCR ncbigene_synonym NMUR1 10316
Homo sapiens Primates GPCR GPCR ncbigene_synonym LPAR3 23566
Homo sapiens Primates GPCR GPCR ncbigene_synonym LGR6 59352
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX3 117195
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX4 117196
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPR151 134391
Homo sapiens Primates GPCR GPCR ncbigene_synonym OXER1 165140
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPRC6A 222545
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX1 259249
Homo sapiens Primates GPCR GPCR ncbigene_synonym VN1R17P 441931
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPR166P 442206
Homo sapiens Primates GPCR GPCR famplex_relations GRM1 2911
Homo sapiens Primates GPCR GPCR famplex_relations GRM2 2912
Homo sapiens Primates GPCR GPCR famplex_relations GRM3 2913
Homo sapiens Primates GPCR GPCR famplex_relations GRM4 2914
Homo sapiens Primates GPCR GPCR famplex_relations GRM5 2915
Homo sapiens Primates GPCR GPCR famplex_relations GRM6 2916
Homo sapiens Primates GPCR GPCR famplex_relations GRM7 2917
Homo sapiens Primates GPCR GPCR famplex_relations GRM8 2918
Homo sapiens Primates GPCR GPCR famplex_relations CASR 846
Homo sapiens Primates GPCR GPCR famplex_relations GABBR1 2550
Homo sapiens Primates GPCR GPCR famplex_relations GABBR2 9568
Homo sapiens Primates GPCR GPCR famplex_relations GPR156 165829
Homo sapiens Primates GPCR GPCR famplex_relations GPR158 57512
Homo sapiens Primates GPCR GPCR famplex_relations GPR179 440435
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5A 9052
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5B 51704
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5C 55890
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5D 55507
Homo sapiens Primates LARG LARG ncbigene_synonym ARHGEF12 23365
Homo sapiens Primates Btk BTK ncbigene_symbol BTK 695
Homo sapiens Primates Tec TEC ncbigene_symbol TEC 7006
Homo sapiens Primates Tec TEC ncbigene_symbol TEC 100124696

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID