Signaling on the endocytic pathway

The figure depicts several types of signaling thought to occur from endosomes, as discussed in the text. Distinct systems are superimposed on the minimum number of endosomal compartments consistent with the presently available data. The figure is an amalgam of data from a number of systems and cell types; thus, only a subset of the indicated signaling events would be expected to occur in any particular cell type. Ligand-induced dimerization of EGF (EGFR) Trk, TGFβ (TGFβR)and Notch is not shown to reduce complexity of the figure. I, internalization; R, recycling; D, degradation; EE, early endosomes; SE/LE, sorting/late endosomes. Endocytic and signaling pathways are shown as broken and solid lines, respectively.
Signaling on the endocytic pathway
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Publication

Signaling on the endocytic pathway. () Mark von Zastrow, et al. Curr Opin Cell Biol. ;19(4):436-445. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates DSL DSL ncbigene_symbol dsl 44897
Drosophila melanogaster Invertebrates Notch NOTCH ncbigene_synonym NA 31293
Drosophila melanogaster Invertebrates EGFR EGFR ncbigene_symbol Egfr 37455
Drosophila melanogaster Invertebrates GPCR GPCR ncbigene_synonym Oamb 43982
Drosophila melanogaster Invertebrates Rab5/ RAB5 ncbigene_symbol Rab5 33418
Drosophila melanogaster Invertebrates EEA.1 EEA1 ncbigene_synonym Rbsn-5 34110
Drosophila melanogaster Invertebrates EE EE ncbigene_symbol ee 45290
Drosophila melanogaster Invertebrates SARA SARA ncbigene_symbol Sara 44263
Drosophila melanogaster Invertebrates Rab11 RAB11 ncbigene_symbol Rab11 42501
Drosophila melanogaster Invertebrates SMAD2 SMAD2 ncbigene_synonym Smox 31738
Drosophila melanogaster Invertebrates PMAPK PMAPK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates p14 P14 ncbigene_synonym Lamtor2 37122
Drosophila melanogaster Invertebrates p14/MP1 MP1 ncbigene_symbol MP1 40541
Drosophila melanogaster Invertebrates p14/MP1 MP1 ncbigene_synonym Lamtor3 35055
Drosophila melanogaster Invertebrates SE SE ncbigene_symbol se 38973
Drosophila melanogaster Invertebrates Rab7 RAB7 ncbigene_symbol Rab7 42841
Drosophila melanogaster Invertebrates CREB CREB ncbigene_synonym CrebB 32817
Drosophila melanogaster Invertebrates CREB CREB ncbigene_synonym CrebA 39682
Drosophila melanogaster Invertebrates Erk ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates Trk TRK ncbigene_symbol trk 34376
Drosophila melanogaster Invertebrates Vps34 VPS34 ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates Vps15/Vps34complex VPS15 ncbigene_symbol Vps15 41096
Homo sapiens Primates TrkA TRKA ncbigene_synonym NTRK1 4914
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH1 4851
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH2 4853
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH3 4854
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH4 4855
Homo sapiens Primates EGFR EGFR ncbigene_symbol EGFR 1956
Homo sapiens Primates TGFBR TGFBR famplex_relations TGFBR1 7046
Homo sapiens Primates TGFBR TGFBR famplex_relations TGFBR2 7048
Homo sapiens Primates TGFBR TGFBR famplex_relations TGFBR3 7049
Homo sapiens Primates GPCR GPCR ncbigene_synonym FZD4 8322
Homo sapiens Primates GPCR GPCR ncbigene_synonym NMUR1 10316
Homo sapiens Primates GPCR GPCR ncbigene_synonym LPAR3 23566
Homo sapiens Primates GPCR GPCR ncbigene_synonym LGR6 59352
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX3 117195
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX4 117196
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPR151 134391
Homo sapiens Primates GPCR GPCR ncbigene_synonym OXER1 165140
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPRC6A 222545
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX1 259249
Homo sapiens Primates GPCR GPCR ncbigene_synonym VN1R17P 441931
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPR166P 442206
Homo sapiens Primates GPCR GPCR famplex_relations GRM1 2911
Homo sapiens Primates GPCR GPCR famplex_relations GRM2 2912
Homo sapiens Primates GPCR GPCR famplex_relations GRM3 2913
Homo sapiens Primates GPCR GPCR famplex_relations GRM4 2914
Homo sapiens Primates GPCR GPCR famplex_relations GRM5 2915
Homo sapiens Primates GPCR GPCR famplex_relations GRM6 2916
Homo sapiens Primates GPCR GPCR famplex_relations GRM7 2917
Homo sapiens Primates GPCR GPCR famplex_relations GRM8 2918
Homo sapiens Primates GPCR GPCR famplex_relations CASR 846
Homo sapiens Primates GPCR GPCR famplex_relations GABBR1 2550
Homo sapiens Primates GPCR GPCR famplex_relations GABBR2 9568
Homo sapiens Primates GPCR GPCR famplex_relations GPR156 165829
Homo sapiens Primates GPCR GPCR famplex_relations GPR158 57512
Homo sapiens Primates GPCR GPCR famplex_relations GPR179 440435
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5A 9052
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5B 51704
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5C 55890
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5D 55507
Homo sapiens Primates Gpa1- GPA1 ncbigene_synonym CGA 1081
Homo sapiens Primates GTP GTP ncbigene_synonym MTG1 92170
Homo sapiens Primates Rab5/ RAB5 ncbigene_synonym RAB5A 5868
Homo sapiens Primates EEA.1 EEA1 ncbigene_symbol EEA1 8411
Homo sapiens Primates SARA SARA ncbigene_synonym ZFYVE9 9372
Homo sapiens Primates SARA SARA ncbigene_synonym SAR1A 56681
Homo sapiens Primates SMAD2 SMAD2 ncbigene_symbol SMAD2 4087
Homo sapiens Primates SMAD2/3 SMAD3 ncbigene_symbol SMAD3 4088
Homo sapiens Primates p14 P14 ncbigene_synonym CDKN2A 1029
Homo sapiens Primates p14 P14 ncbigene_synonym S100A9 6280
Homo sapiens Primates p14 P14 ncbigene_synonym CDK2AP2 10263
Homo sapiens Primates p14 P14 ncbigene_synonym SUB1 10923
Homo sapiens Primates p14 P14 ncbigene_synonym RPP14 11102
Homo sapiens Primates p14 P14 ncbigene_synonym LAMTOR2 28956
Homo sapiens Primates p14 P14 ncbigene_synonym SF3B6 51639
Homo sapiens Primates p14 P14 ncbigene_synonym H3P8 115482693
Homo sapiens Primates p14/MP1 MP1 ncbigene_synonym LAMTOR3 8649
Homo sapiens Primates p14/MP1 MP1 ncbigene_synonym PITRM1 10531
Homo sapiens Primates ERK1 ERK1 ncbigene_synonym MAPK3 5595
Homo sapiens Primates ERK1/2 ERK2 ncbigene_synonym MAPK1 5594
Homo sapiens Primates MEK1 MEK1 ncbigene_synonym MAP2K1 5604
Homo sapiens Primates Rab7 RAB7 ncbigene_synonym RAB7A 7879
Homo sapiens Primates Rab7 RAB7 ncbigene_synonym RAB7B 338382
Homo sapiens Primates CREB CREB ncbigene_synonym CREB1 1385
Homo sapiens Primates CREB CREB famplex_relations CREB3 10488
Homo sapiens Primates CREB CREB famplex_relations CREB5 9586
Homo sapiens Primates CREB CREB famplex_relations CREB3L1 90993
Homo sapiens Primates CREB CREB famplex_relations CREB3L2 64764
Homo sapiens Primates CREB CREB famplex_relations CREB3L3 84699
Homo sapiens Primates CREB CREB famplex_relations CREB3L4 148327
Homo sapiens Primates CREB CREB famplex_relations CREM 1390
Homo sapiens Primates CREB CREB famplex_relations ATF1 466
Homo sapiens Primates CREB CREB famplex_relations ATF2 1386
Homo sapiens Primates Erk ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates EGF EGF ncbigene_symbol EGF 1950
Homo sapiens Primates Trk TRK ncbigene_synonym TPM3 7170
Homo sapiens Primates Vps34 VPS34 ncbigene_synonym PIK3C3 5289
Homo sapiens Primates Vps15/Vps34complex VPS15 ncbigene_synonym PIK3R4 30849

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID