Beta-Arrestin–mediated B1-adrenergic receptor transactivation of the EGFR confers cardioprotection

Ligand stimulation of the β1AR leads to GRK5/6-mediated receptor phosphorylation and β-arrestin recruitment. β-Arrestin recruits Src, which leads to MMP activation to promote HB-EGF shedding. HB-EGF binds with the EGFR to induce dimerization and autophosphorylation and subsequent downstream signaling.
Beta-Arrestin–mediated B1-adrenergic receptor transactivation of the EGFR confers cardioprotection
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Publication

β-Arrestin–mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection . (2007) Takahisa Noma, et al. J Clin Invest. 2007 Sep 4;117(9):2445-2458. Figure: F9.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Src SRC ncbigene_symbol SRC 6714
Homo sapiens Primates Src SRC famplex_relations FGR 2268
Homo sapiens Primates Src SRC famplex_relations FYN 2534
Homo sapiens Primates Src SRC famplex_relations YES1 7525
Homo sapiens Primates MMP MMP famplex_relations MMP1 4312
Homo sapiens Primates MMP MMP famplex_relations MMP2 4313
Homo sapiens Primates MMP MMP famplex_relations MMP3 4314
Homo sapiens Primates MMP MMP famplex_relations MMP7 4316
Homo sapiens Primates MMP MMP famplex_relations MMP8 4317
Homo sapiens Primates MMP MMP famplex_relations MMP9 4318
Homo sapiens Primates MMP MMP famplex_relations MMP10 4319
Homo sapiens Primates MMP MMP famplex_relations MMP11 4320
Homo sapiens Primates MMP MMP famplex_relations MMP12 4321
Homo sapiens Primates MMP MMP famplex_relations MMP13 4322
Homo sapiens Primates MMP MMP famplex_relations MMP14 4323
Homo sapiens Primates MMP MMP famplex_relations MMP15 4324
Homo sapiens Primates MMP MMP famplex_relations MMP16 4325
Homo sapiens Primates MMP MMP famplex_relations MMP17 4326
Homo sapiens Primates MMP MMP famplex_relations MMP19 4327
Homo sapiens Primates MMP MMP famplex_relations MMP20 9313
Homo sapiens Primates MMP MMP famplex_relations MMP21 118856
Homo sapiens Primates MMP MMP famplex_relations MMP23B 8510
Homo sapiens Primates MMP MMP famplex_relations MMP24 10893
Homo sapiens Primates MMP MMP famplex_relations MMP25 64386
Homo sapiens Primates MMP MMP famplex_relations MMP26 56547
Homo sapiens Primates MMP MMP famplex_relations MMP27 64066
Homo sapiens Primates MMP MMP famplex_relations MMP28 79148
Homo sapiens Primates HB-EGF HBEGF ncbigene_symbol HBEGF 1839
Homo sapiens Primates EGFR EGFR ncbigene_symbol EGFR 1956
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates GRK5,-6 GRK5 ncbigene_symbol GRK5 2869
Mus musculus Rodents Src SRC ncbigene_symbol Src 20779
Mus musculus Rodents HB-EGF HBEGF ncbigene_symbol Hbegf 15200
Mus musculus Rodents EGFR EGFR ncbigene_symbol Egfr 13649
Mus musculus Rodents ERK ERK ncbigene_synonym Ephb2 13844
Mus musculus Rodents ERK ERK ncbigene_synonym Mapk1 26413
Mus musculus Rodents GRK5,-6 GRK5 ncbigene_symbol Grk5 14773
Drosophila melanogaster Invertebrates Src SRC ncbigene_synonym Src42A 35524
Drosophila melanogaster Invertebrates Src SRC ncbigene_synonym Csk 41398
Drosophila melanogaster Invertebrates Src SRC ncbigene_synonym Src64B 48973
Drosophila melanogaster Invertebrates B-arrestin B-ARRESTIN ncbigene_synonym Arr2 38993
Drosophila melanogaster Invertebrates MMP MMP ncbigene_synonym Mmp1 37949
Drosophila melanogaster Invertebrates EGFR EGFR ncbigene_symbol Egfr 37455
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym rl 3354888

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID