TGFB signaling pathway

The TGF-β signaling pathway. Binding of TGF-β to TGF-β receptor II recruits TGF-β receptor I (TGF-βR-I). The kinase domain of TGF-βR-I phosphorylates Smad2 and 3, which form a heteromeric complex with Smad4 that translocates into the nucleus where it activates transcription of target genes. Numbers indicate points in the pathway where PPARγ ligands have been demonstrated to interfere with TGF-β signaling. (1) GW7845, a PPARγ ligand, inhibited Smad3 phosphorylation in human hepatic stellate cells []. (2) 15d-PGJ2 inhibited nuclear translocation of Smad2/3 in rat kidney fibroblasts []. (3) In human renal mesangial cells, 15d-PGJ2 induced hepatocyte growth factor (HGF), which upregulates the Smad corepressor TG-interacting factor (TGIF) []. (4) In mouse L929 fibroblasts, 15d-PGJ2 or retinoic acid upregulated the phosphatase and tensin homologue deleted on chromosome 10 (PTEN), leading to repression of TGF-β1 transcription [].
TGFB signaling pathway
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Publication

The Role of PPARs in Lung Fibrosis. (2007) Heather F. Lakatos, et al. PPAR Res. 2007;2007:71323. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents TGFBR-1 TGFBR1 ncbigene_symbol Tgfbr1 21812
Mus musculus Rodents →TGFBR-II TGFBR2 ncbigene_symbol Tgfbr2 21813
Mus musculus Rodents Smad2 SMAD2 ncbigene_symbol Smad2 17126
Mus musculus Rodents Smad2/3 SMAD3 ncbigene_symbol Smad3 17127
Mus musculus Rodents Smad4 SMAD4 ncbigene_symbol Smad4 17128
Mus musculus Rodents HGF HGF ncbigene_symbol Hgf 15234
Mus musculus Rodents HGF HGF ncbigene_synonym Met 17295
Mus musculus Rodents TGIF TGIF ncbigene_synonym Tgif1 21815
Mus musculus Rodents TGFB TGFB ncbigene_synonym Tgfb1 21803
Mus musculus Rodents TGFB TGFB ncbigene_synonym Ltbp1 268977
Rattus norvegicus Rodents TGFBR-1 TGFBR1 ncbigene_symbol Tgfbr1 29591
Rattus norvegicus Rodents →TGFBR-II TGFBR2 ncbigene_symbol Tgfbr2 81810
Rattus norvegicus Rodents Smad2 SMAD2 ncbigene_symbol Smad2 29357
Rattus norvegicus Rodents Smad2/3 SMAD3 ncbigene_symbol Smad3 25631
Rattus norvegicus Rodents Smad4 SMAD4 ncbigene_symbol Smad4 50554
Rattus norvegicus Rodents HGF HGF ncbigene_symbol Hgf 24446
Rattus norvegicus Rodents TGIF TGIF ncbigene_synonym Tgif1 316742
Rattus norvegicus Rodents TGFB TGFB ncbigene_synonym Tgfb1 59086
Homo sapiens Primates TGFBR-1 TGFBR1 ncbigene_symbol TGFBR1 7046
Homo sapiens Primates →TGFBR-II TGFBRII ncbigene_synonym TGFBR2 7048
Homo sapiens Primates Smad2 SMAD2 ncbigene_symbol SMAD2 4087
Homo sapiens Primates Smad2/3 SMAD3 ncbigene_symbol SMAD3 4088
Homo sapiens Primates Smad4 SMAD4 ncbigene_symbol SMAD4 4089
Homo sapiens Primates HGF HGF ncbigene_symbol HGF 3082
Homo sapiens Primates HGF HGF ncbigene_synonym IL6 3569
Homo sapiens Primates HGF HGF ncbigene_synonym SOS1 6654
Homo sapiens Primates TGIF TGIF ncbigene_synonym IL10 3586
Homo sapiens Primates TGIF TGIF ncbigene_synonym TGIF1 7050
Homo sapiens Primates TGFB TGFB ncbigene_synonym TGFB1 7040
Homo sapiens Primates TGFB TGFB famplex_relations TGFB2 7042
Homo sapiens Primates TGFB TGFB famplex_relations TGFB3 7043

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID