GM-CSF Regulates a PU.1-Dependent Transcriptional Program Determining the Pulmonary Response to LPS

Proposed mechanism by which GM-CSF regulates AM-mediated proinflammatory cytokine signaling and neutrophil recruitment upon exposure to Pseudomonas LPS. GM-CSF receptor binding stimulates increased levels of the transcription factor, PU.1, in AMs (see Ref. 6). In turn, PU.1 stimulates expression of TLR-4 signaling pathway components (arrows). Expression of other TLR-4 components in alveolar macrophages is unaffected by GM-CSF or PU.1 (unmarked).
GM-CSF Regulates a PU.1-Dependent Transcriptional Program Determining the Pulmonary Response to LPS
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Publication

GM-CSF Regulates a PU.1-Dependent Transcriptional Program Determining the Pulmonary Response to LPS. (2007) Pierre-Yves Berclaz, et al. Am J Respir Cell Mol Biol. 2007 Jan;36(1):114-121. Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates LPS LPS ncbigene_synonym IRF6 3664
Homo sapiens Primates MD-2 MD-2 ncbigene_synonym LY96 23643
Homo sapiens Primates CD-14 CD14 ncbigene_symbol CD14 929
Homo sapiens Primates CD-14 CD14 ncbigene_synonym NDUFA2 4695
Homo sapiens Primates GM-CSF GMCSF ncbigene_synonym CSF2 1437
Homo sapiens Primates TLR-4 TLR-4 ncbigene_synonym TLR4 7099
Homo sapiens Primates RP105 RP105 ncbigene_synonym CD180 4064
Homo sapiens Primates TIRAP TIRAP ncbigene_symbol TIRAP 114609
Homo sapiens Primates TIRAP/Mal MAL ncbigene_symbol MAL 4118
Homo sapiens Primates TIRAP/Mal MAL ncbigene_synonym MRTFA 57591
Homo sapiens Primates TIRAP/Mal MA1 ncbigene_synonym PNMA1 9240
Homo sapiens Primates TIRAP/Mal MAI ncbigene_synonym GSTZ1 2954
Homo sapiens Primates MYD88 MYD88 ncbigene_symbol MYD88 4615
Homo sapiens Primates IRAK-4 IRAK-4 ncbigene_synonym IRAK4 51135
Homo sapiens Primates IRAK-1 IRAK1 ncbigene_symbol IRAK1 3654
Homo sapiens Primates IRAK-M IRAKM ncbigene_synonym IRAK3 11213
Homo sapiens Primates TRAF6 TRAF6 ncbigene_symbol TRAF6 7189
Homo sapiens Primates PU.1 PU.1 ncbigene_synonym SPI1 6688
Homo sapiens Primates NFKB NFKB ncbigene_synonym NFKB1 4790
Homo sapiens Primates NFKB NFKB famplex_relations RELA 5970
Homo sapiens Primates NFKB NFKB famplex_relations RELB 5971
Homo sapiens Primates NFKB NFKB famplex_relations REL 5966
Homo sapiens Primates NFKB NFKB famplex_relations NFKB2 4791
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL10 3627
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL11 6373
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL12 6387
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL13 10563
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL14 9547
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL9 4283
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations PF4 5196
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL1 2919
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL2 2920
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL3 2921
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL5 6374
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL6 6372
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations CXCL8 3576
Homo sapiens Primates Chemokine CHEMOKINE famplex_relations PPBP 5473
Homo sapiens Primates Tollip TOLLIP ncbigene_symbol TOLLIP 54472
Mus musculus Rodents LPS LPS ncbigene_synonym Tlr4 21898
Mus musculus Rodents MD-2 MD-2 ncbigene_synonym Ly96 17087
Mus musculus Rodents CD-14 CD14 ncbigene_symbol Cd14 12475
Mus musculus Rodents GM-CSF GM-CSF ncbigene_synonym Csf2 12981
Mus musculus Rodents RP105 RP105 ncbigene_synonym Gpr83 14608
Mus musculus Rodents RP105 RP105 ncbigene_synonym Cd180 17079
Mus musculus Rodents TIRAP TIRAP ncbigene_symbol Tirap 117149
Mus musculus Rodents TIRAP/Mal MAL ncbigene_symbol Mal 17153
Mus musculus Rodents TIRAP/Mal MAL ncbigene_synonym Mrtfa 223701
Mus musculus Rodents MYD88 MYD88 ncbigene_symbol Myd88 17874
Mus musculus Rodents IRAK-4 IRAK-4 ncbigene_synonym Irak4 266632
Mus musculus Rodents IRAK-1 IRAK-1 ncbigene_synonym Irak1 16179
Mus musculus Rodents IRAK-M IRAK-M ncbigene_synonym Irak3 73914
Mus musculus Rodents TRAF6 TRAF6 ncbigene_symbol Traf6 22034
Mus musculus Rodents PU.1 PU.1 ncbigene_synonym Spi1 20375
Mus musculus Rodents IKB IKB ncbigene_synonym Nfkbib 18036
Mus musculus Rodents NFKB NFKB ncbigene_synonym Nfkb1 18033
Mus musculus Rodents Tollip TOLLIP ncbigene_symbol Tollip 54473
Danio rerio Vertebrates TIRAP TIRAP ncbigene_symbol tirap 403148
Danio rerio Vertebrates TIRAP/Mal MAL ncbigene_synonym malb 550381
Danio rerio Vertebrates MYD88 MYD88 ncbigene_symbol myd88 403145
Danio rerio Vertebrates IRAK-4 IRAK4 ncbigene_symbol irak4 393132
Danio rerio Vertebrates IRAK-1 IRAK1 ncbigene_symbol irak1 569226
Danio rerio Vertebrates TRAF6 TRAF6 ncbigene_symbol traf6 554561
Danio rerio Vertebrates PU.1 PU.1 ncbigene_synonym spi1b 30117
Danio rerio Vertebrates Tollip TOLLIP ncbigene_symbol tollip 336876

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID