Pathways for the synthesis of the major phospholipids in S
Pathways for the synthesis of the major phospholipids in S. cerevisiae. The pathways shown for the synthesis of phospholipids include the relevant steps discussed in the review. The CDP-DG pathway enzymes (PSS, PS synthase; PSD, PS decarboxylase; PEMT, PE methyltransferase; and PLMT, phospholipid methyltransferase) are highlighted in red. The Kennedy pathway enzymes (EK, ethanolamine kinase; ECT, phosphoethanolamine cytidylyltransferase; EPT, ethanolaminephosphotransferase; CK, choline kinase; CCT, phosphocholine cytidylyltransferase; CPT, cholinephosphotransferase) are highlighted in blue. IPS, inositol phosphate synthase; IPP, inositol phosphate phosphatase; PIS, PI synthase; DPP, DGPP phosphatase; PAP, PA phosphatase; DGA, DG acyltransferase; CTPS, CTP synthetase.
Publication
Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc depletion. () George M. Carman, et al. Biochim Biophys Acta. ;1771(3):322-330. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | PEMT | PEMT | ncbigene_symbol | PEMT | 10400 |
| Homo sapiens | Primates | PEMT | PEMT | ncbigene_synonym | MUC1 | 4582 |
| Homo sapiens | Primates | PSD | PSD | ncbigene_symbol | PSD | 5662 |
| Homo sapiens | Primates | PSD | PSD | ncbigene_synonym | PISD | 23761 |
| Homo sapiens | Primates | PSD | PSD | ncbigene_synonym | FBXL15 | 79176 |
| Homo sapiens | Primates | PC | PC | ncbigene_symbol | PC | 5091 |
| Homo sapiens | Primates | TG | TG | ncbigene_symbol | TG | 7038 |
| Homo sapiens | Primates | CH,CH, | CHCH | ncbigene_synonym | CHURC1 | 91612 |
| Homo sapiens | Primates | PSS | PSS | ncbigene_symbol | PSS | 780904 |
| Homo sapiens | Primates | PSS | PSS | ncbigene_synonym | CDSN | 1041 |
| Homo sapiens | Primates | CMP | CMP | ncbigene_synonym | MATN1 | 4146 |
| Homo sapiens | Primates | PAP | PAP | ncbigene_synonym | REG3A | 5068 |
| Homo sapiens | Primates | PAP | PAP | ncbigene_synonym | ASAP2 | 8853 |
| Homo sapiens | Primates | PAP | PAP | ncbigene_synonym | MRPS30 | 10884 |
| Homo sapiens | Primates | PAP | PAP | ncbigene_synonym | PAPOLA | 10914 |
| Homo sapiens | Primates | PAP | PAP | ncbigene_synonym | PDAP1 | 11333 |
| Homo sapiens | Primates | PAP | PAP | ncbigene_synonym | TUSC2 | 11334 |
| Homo sapiens | Primates | PAP | PAP | ncbigene_synonym | ASAP1 | 50807 |
| Homo sapiens | Primates | EPT | EPT | ncbigene_synonym | LGI1 | 9211 |
| Homo sapiens | Primates | CPT | CPT | ncbigene_synonym | CHPT1 | 56994 |
| Homo sapiens | Primates | CPT | CPT | ncbigene_synonym | DHDDS | 79947 |
| Homo sapiens | Primates | CTP | CTP | ncbigene_synonym | SLC25A1 | 6576 |
| Homo sapiens | Primates | PIS | PIS | ncbigene_synonym | CDIPT | 10423 |
| Homo sapiens | Primates | DPP | DPP | ncbigene_synonym | DSPP | 1834 |
| Homo sapiens | Primates | CCT | CCT | ncbigene_symbol | CCT | 907 |
| Homo sapiens | Primates | CCT | CCT | ncbigene_synonym | FLVCR2 | 55640 |
| Homo sapiens | Primates | CCT | CCT | famplex_relations | CCT2 | 10576 |
| Homo sapiens | Primates | CCT | CCT | famplex_relations | CCT3 | 7203 |
| Homo sapiens | Primates | CCT | CCT | famplex_relations | CCT4 | 10575 |
| Homo sapiens | Primates | CCT | CCT | famplex_relations | CCT5 | 22948 |
| Homo sapiens | Primates | CCT | CCT | famplex_relations | CCT6A | 908 |
| Homo sapiens | Primates | CCT | CCT | famplex_relations | CCT6B | 10693 |
| Homo sapiens | Primates | CCT | CCT | famplex_relations | CCT7 | 10574 |
| Homo sapiens | Primates | CCT | CCT | famplex_relations | CCT8 | 10694 |
| Homo sapiens | Primates | CCT | CCT | famplex_relations | TCP1 | 6950 |
| Homo sapiens | Primates | ECT | ECT | ncbigene_symbol | ECT | 100379198 |
| Homo sapiens | Primates | IPP | IPP | ncbigene_symbol | IPP | 3652 |
| Homo sapiens | Primates | CTPS | CTPS | ncbigene_synonym | CTPS1 | 1503 |
| Homo sapiens | Primates | ADP- | ADP | ncbigene_synonym | WDTC1 | 23038 |
| Homo sapiens | Primates | IPS | IPS | ncbigene_synonym | SLC27A4 | 10999 |
| Homo sapiens | Primates | IPS | IPS | ncbigene_synonym | ISYNA1 | 51477 |
| Homo sapiens | Primates | ATP | ATP | ncbigene_synonym | ATP8A2 | 51761 |
| Drosophila melanogaster | Invertebrates | PE- | PE | ncbigene_symbol | pe | 252319 |
| Drosophila melanogaster | Invertebrates | PSD | PSD | ncbigene_symbol | psd | 33830 |
| Drosophila melanogaster | Invertebrates | PSD | PSD | ncbigene_synonym | Pisd | 42849 |
| Drosophila melanogaster | Invertebrates | PS | PS | ncbigene_symbol | ps | 44258 |
| Drosophila melanogaster | Invertebrates | PC | PC | ncbigene_symbol | Pc | 40358 |
| Drosophila melanogaster | Invertebrates | TG | TG | ncbigene_symbol | Tg | 34093 |
| Drosophila melanogaster | Invertebrates | DGA | DGA | ncbigene_symbol | dg-a | 248326 |
| Drosophila melanogaster | Invertebrates | PSS | PSS | ncbigene_symbol | Pss | 40281 |
| Drosophila melanogaster | Invertebrates | DG | DG | ncbigene_symbol | Dg | 36773 |
| Drosophila melanogaster | Invertebrates | DG | DG | ncbigene_synonym | AP-1gamma | 31842 |
| Drosophila melanogaster | Invertebrates | CMP | CMP | ncbigene_symbol | cmp | 248126 |
| Drosophila melanogaster | Invertebrates | PAP | PAP | ncbigene_synonym | wisp | 32152 |
| Drosophila melanogaster | Invertebrates | PAP | PAP | ncbigene_synonym | PAPLA1 | 34109 |
| Drosophila melanogaster | Invertebrates | PAP | PAP | ncbigene_synonym | Pli | 42821 |
| Drosophila melanogaster | Invertebrates | PAP | PAP | ncbigene_synonym | 43193 | |
| Drosophila melanogaster | Invertebrates | PAP | PAP | ncbigene_synonym | skd | 43906 |
| Drosophila melanogaster | Invertebrates | PAP | PAP | ncbigene_synonym | hrg | 49636 |
| Drosophila melanogaster | Invertebrates | CDS | CDS | ncbigene_symbol | Cds | 43950 |
| Drosophila melanogaster | Invertebrates | CDS | CDS | ncbigene_symbol | cd-s | 250671 |
| Drosophila melanogaster | Invertebrates | EPT | EPT | ncbigene_synonym | bbc | 36496 |
| Drosophila melanogaster | Invertebrates | EPT | EPT | ncbigene_synonym | TSG101 | 39881 |
| Drosophila melanogaster | Invertebrates | CPT | CPT | ncbigene_symbol | Cpt | 248169 |
| Drosophila melanogaster | Invertebrates | CPT | CPT | ncbigene_synonym | CG7149 | 34063 |
| Drosophila melanogaster | Invertebrates | CPT | CPT | ncbigene_synonym | CPT2 | 38355 |
| Drosophila melanogaster | Invertebrates | PA | PA | ncbigene_symbol | Pa | 251550 |
| Drosophila melanogaster | Invertebrates | CTP | CTP | ncbigene_symbol | ctp | 31405 |
| Drosophila melanogaster | Invertebrates | PIS | PIS | ncbigene_symbol | Pis | 32506 |
| Drosophila melanogaster | Invertebrates | DPP | DPP | ncbigene_symbol | dpp | 33432 |
| Drosophila melanogaster | Invertebrates | DPP | DPP | ncbigene_synonym | DppIII | 40996 |
| Drosophila melanogaster | Invertebrates | CCT | CCT | ncbigene_synonym | beat-Ia | 34947 |
| Drosophila melanogaster | Invertebrates | CCT | CCT | ncbigene_synonym | Pcyt1 | 117353 |
| Drosophila melanogaster | Invertebrates | ECT | ECT | ncbigene_symbol | ect | 44135 |
| Drosophila melanogaster | Invertebrates | IPP | IPP | ncbigene_symbol | Ipp | 41701 |
| Drosophila melanogaster | Invertebrates | IPP | IPP | ncbigene_synonym | CG9784 | 32629 |
| Drosophila melanogaster | Invertebrates | IPP | IPP | ncbigene_synonym | CG9426 | 34719 |
| Drosophila melanogaster | Invertebrates | IPP | IPP | ncbigene_synonym | CG6805 | 36911 |
| Drosophila melanogaster | Invertebrates | IPP | IPP | ncbigene_synonym | Synj | 37517 |
| Drosophila melanogaster | Invertebrates | IPP | IPP | ncbigene_synonym | INPP5E | 39404 |
| Drosophila melanogaster | Invertebrates | IPP | IPP | ncbigene_synonym | 5PtaseI | 326119 |
| Drosophila melanogaster | Invertebrates | CTPS | CTPS | ncbigene_synonym | CTPsyn | 39645 |
| Drosophila melanogaster | Invertebrates | PI | PI | ncbigene_symbol | pi | 5656965 |
| Drosophila melanogaster | Invertebrates | ADP- | ADP | ncbigene_symbol | adp | 37073 |
| Drosophila melanogaster | Invertebrates | CK | CK | ncbigene_symbol | ck | 34882 |
| Drosophila melanogaster | Invertebrates | ATP | ATP | ncbigene_synonym | ATPsynbeta | 43829 |
| Drosophila melanogaster | Invertebrates | ATP | ATP | ncbigene_synonym | Atpalpha | 48971 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| CDP-ethanolamine | CDP-ethanolamine | mesh:C006933 | CDP ethanolamine | chebi:16732 |
| Inositol-3-phosphate | NA | mesh:C052128 | ||
| Choline | Choline | mesh:D002794 | choline | chebi:15354 |
| P-choline | Choline | mesh:D002794 | choline | chebi:15354 |
| CDP | Cytidine Diphosphate | mesh:D003565 | CDP | chebi:17239 |
| CDP-Choline | Cytidine Diphosphate Choline | mesh:D003566 | CDP-choline | chebi:16436 |
| CMP | Cytidine Monophosphate | mesh:D003568 | cytidine 5'-monophosphate | chebi:17361 |
| Ethanolamine | Ethanolamines | mesh:D004983 | ethanolamines | chebi:23981 |
| P-ethanolamine | Ethanolamines | mesh:D004983 | ethanolamines | chebi:23981 |
| Inositol | Inositol | mesh:D007294 | myo-inositol | chebi:17268 |
| Serine | Serine | mesh:D012694 | L-serine | chebi:17115 |
| UTP | Uridine Triphosphate | mesh:D014544 | UTP | chebi:15713 |
| Glucose-6-phosphate | NA | mesh:D019298 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|