Hedgehog signalling pathway

The Hedgehog signalling pathway. Positive regulators of the Hedgehog (Hh) pathway are shown in green, whereas negative regulators are shown in red. Although many of the components seem to have both positive and negative activities under different conditions, the component is colour-coded according to its predominant activity. Components of the pathway that do not seem to be conserved between Drosophila and mammals are shown in ovals. This figure is intended to summarize the key concepts about Hh signalling discussed at this workshop, and is not intended to represent all the known components of the pathway. Akt; cellular homologue of the transforming gene of the AKT8 provirus; β-TrCP; β-transducin repeat-containing protein; CDK11; cyclin-dependent kinase 11; Ci, Cubitus interruptus; CK1, casein kinase 1; COPI, coat protein 1; Cos2, Costal2; Cul, Cullin; Debra, determiner of breaking down of Ci activator; Fu, Fused; GSK3, glycogen synthase kinase 3; HIB, Hh-inducible BTB protein; HIP, Hh-interacting protein; HMGCoA, 3-hydroxy-3-methyl-glutaryl-CoA; HSPG, heparan sulphate proteoglycan; IFT, intraflagellar transport; Ihogs, Interference Hedgehogs; Itch, Itchy homologue E3 ubiquitin protein ligase; Numb, protein involved in asymmetric cell division; PITSTRE, a family of protein kinases containing this conserved sequence within its active site; PKA, protein kinase A; pp2A, protein phosphatase 2A; Ptc, Patched; Ras, monomeric G-protein; Ren, a gene that is upregulated by retinoic acid, epidermal growth factor and nerve growth factor; Shf, Shifted; Slimb, supernumerary limbs; Smo, Smoothened; SPOP, speckle-type POZ protein; SREBP, sterol regulatory element-binding protein; Su(fu), Suppressor of Fused; Sulft1, Sulfateless 1.

Publication

Hedgehogs: la dolce vita. Workshop on Hedgehog-Gli Signaling in Cancer and Stem Cells. (2007) David J Robbins, et al. EMBO Rep. 2007 May;8(5):451-455. Figure: F1. All organisms Drosophila melanogaster Homo sapiens

Disease mentions