Intracellular signaling cascades activated by BDNF-stimulated autophosphorylation of TrkB receptors may affect prominent pathways responsible for elevations of intracellular Ca2+ levels in neurons

Intracellular signaling cascades activated by BDNF-stimulated autophosphorylation of TrkB receptors may affect prominent pathways responsible for elevations of intracellular Ca2+ levels in neurons. Activation of the PLC-γ/IP3signaling pathway leads to Ca2+ mobilization from IP3-sensitive intracellular stores. In addition, NMDA receptors and voltage-gated Ca2+ channels could be directly phosphorylated by activated TrkB receptors or indirectly through the Ras-MAPK/ERK or PI3-K pathways. Combined, these covalent modifications potentially enhance Ca2+ signals within spines and dendrites.
Intracellular signaling cascades activated by BDNF-stimulated autophosphorylation of TrkB receptors may affect prominent pathways responsible for elevations of intracellular Ca2+ levels in neurons

Publication

TRPC Channels as Novel Effectors of BDNF Signaling: Potential Implications for Rett Syndrome. () Michelle D. Amaral, et al. Pharmacol Ther. ;113(2):394-409. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates BDNF BDNF ncbigene_symbol BDNF 627
Homo sapiens Primates BDNF BDNF ncbigene_synonym BDNF-AS 497258
Homo sapiens Primates TrkB TRKB ncbigene_synonym NTRK2 4915
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates Gab-1 GAB1 ncbigene_symbol GAB1 2549
Homo sapiens Primates Gab-1 GAB1 ncbigene_synonym PIGU 128869
Homo sapiens Primates Grb2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates PI-3 PI3 ncbigene_symbol PI3 5266
Homo sapiens Primates She SHE ncbigene_symbol SHE 126669
Homo sapiens Primates SOS SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates SOS SOS famplex_relations SOS1 6654
Homo sapiens Primates SOS SOS famplex_relations SOS2 6655
Homo sapiens Primates PLCY PLCG famplex_relations PLCG1 5335
Homo sapiens Primates PLCY PLCG famplex_relations PLCG2 5336
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates Aktl AKT1 ncbigene_symbol AKT1 207
Homo sapiens Primates (Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates (Raf RAF famplex_relations ARAF 369
Homo sapiens Primates (Raf RAF famplex_relations BRAF 673
Homo sapiens Primates (Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates CREB CREB ncbigene_synonym CREB1 1385
Homo sapiens Primates CREB CREB famplex_relations CREB3 10488
Homo sapiens Primates CREB CREB famplex_relations CREB5 9586
Homo sapiens Primates CREB CREB famplex_relations CREB3L1 90993
Homo sapiens Primates CREB CREB famplex_relations CREB3L2 64764
Homo sapiens Primates CREB CREB famplex_relations CREB3L3 84699
Homo sapiens Primates CREB CREB famplex_relations CREB3L4 148327
Homo sapiens Primates CREB CREB famplex_relations CREM 1390
Homo sapiens Primates CREB CREB famplex_relations ATF1 466
Homo sapiens Primates CREB CREB famplex_relations ATF2 1386

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Cardiomyopathy NA
Noonan syndrome NA