Intracellular signaling cascades activated by BDNF-stimulated autophosphorylation of TrkB receptors may affect prominent pathways responsible for elevations of intracellular Ca2+ levels in neurons
Intracellular signaling cascades activated by BDNF-stimulated autophosphorylation of TrkB receptors may affect prominent pathways responsible for elevations of intracellular Ca2+ levels in neurons. Activation of the PLC-γ/IP3signaling pathway leads to Ca2+ mobilization from IP3-sensitive intracellular stores. In addition, NMDA receptors and voltage-gated Ca2+ channels could be directly phosphorylated by activated TrkB receptors or indirectly through the Ras-MAPK/ERK or PI3-K pathways. Combined, these covalent modifications potentially enhance Ca2+ signals within spines and dendrites.

Publication
TRPC Channels as Novel Effectors of BDNF Signaling: Potential Implications for Rett Syndrome. () Michelle D. Amaral, et al. Pharmacol Ther. ;113(2):394-409. Figure: F1.Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
---|---|---|---|---|---|---|
Homo sapiens | Primates | BDNF | BDNF | ncbigene_symbol | BDNF | 627 |
Homo sapiens | Primates | BDNF | BDNF | ncbigene_synonym | BDNF-AS | 497258 |
Homo sapiens | Primates | TrkB | TRKB | ncbigene_synonym | NTRK2 | 4915 |
Homo sapiens | Primates | PKC | PKC | ncbigene_synonym | PRRT2 | 112476 |
Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCA | 5578 |
Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCB | 5579 |
Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCD | 5580 |
Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCE | 5581 |
Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCG | 5582 |
Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCH | 5583 |
Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCI | 5584 |
Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCQ | 5588 |
Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCZ | 5590 |
Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKD3 | 23683 |
Homo sapiens | Primates | Gab-1 | GAB1 | ncbigene_symbol | GAB1 | 2549 |
Homo sapiens | Primates | Gab-1 | GAB1 | ncbigene_synonym | PIGU | 128869 |
Homo sapiens | Primates | Grb2 | GRB2 | ncbigene_symbol | GRB2 | 2885 |
Homo sapiens | Primates | PI-3 | PI3 | ncbigene_symbol | PI3 | 5266 |
Homo sapiens | Primates | She | SHE | ncbigene_symbol | SHE | 126669 |
Homo sapiens | Primates | SOS | SOS | ncbigene_synonym | XYLT2 | 64132 |
Homo sapiens | Primates | SOS | SOS | famplex_relations | SOS1 | 6654 |
Homo sapiens | Primates | SOS | SOS | famplex_relations | SOS2 | 6655 |
Homo sapiens | Primates | PLCY | PLCG | famplex_relations | PLCG1 | 5335 |
Homo sapiens | Primates | PLCY | PLCG | famplex_relations | PLCG2 | 5336 |
Homo sapiens | Primates | Ras | RAS | famplex_relations | KRAS | 3845 |
Homo sapiens | Primates | Ras | RAS | famplex_relations | HRAS | 3265 |
Homo sapiens | Primates | Ras | RAS | famplex_relations | NRAS | 4893 |
Homo sapiens | Primates | Aktl | AKT1 | ncbigene_symbol | AKT1 | 207 |
Homo sapiens | Primates | (Raf | RAF | ncbigene_synonym | ZHX2 | 22882 |
Homo sapiens | Primates | (Raf | RAF | famplex_relations | ARAF | 369 |
Homo sapiens | Primates | (Raf | RAF | famplex_relations | BRAF | 673 |
Homo sapiens | Primates | (Raf | RAF | famplex_relations | RAF1 | 5894 |
Homo sapiens | Primates | ERK | ERK | ncbigene_synonym | EPHB2 | 2048 |
Homo sapiens | Primates | ERK | ERK | ncbigene_synonym | MAPK1 | 5594 |
Homo sapiens | Primates | ERK | ERK | famplex_relations | MAPK3 | 5595 |
Homo sapiens | Primates | MEK | MEK | ncbigene_synonym | MAP2K7 | 5609 |
Homo sapiens | Primates | MEK | MEK | famplex_relations | MAP2K1 | 5604 |
Homo sapiens | Primates | MEK | MEK | famplex_relations | MAP2K2 | 5605 |
Homo sapiens | Primates | CREB | CREB | ncbigene_synonym | CREB1 | 1385 |
Homo sapiens | Primates | CREB | CREB | famplex_relations | CREB3 | 10488 |
Homo sapiens | Primates | CREB | CREB | famplex_relations | CREB5 | 9586 |
Homo sapiens | Primates | CREB | CREB | famplex_relations | CREB3L1 | 90993 |
Homo sapiens | Primates | CREB | CREB | famplex_relations | CREB3L2 | 64764 |
Homo sapiens | Primates | CREB | CREB | famplex_relations | CREB3L3 | 84699 |
Homo sapiens | Primates | CREB | CREB | famplex_relations | CREB3L4 | 148327 |
Homo sapiens | Primates | CREB | CREB | famplex_relations | CREM | 1390 |
Homo sapiens | Primates | CREB | CREB | famplex_relations | ATF1 | 466 |
Homo sapiens | Primates | CREB | CREB | famplex_relations | ATF2 | 1386 |
Word | Match | MeSH | Name | ChEBI |
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Disease mentions
Word | Match | MeSH | Name | DOID |
---|---|---|---|---|
Cancer | NA | |||
Cardiomyopathy | NA | |||
Noonan syndrome | NA |