Physiology and immunology of the cholinergic antiinflammatory pathway
Cholinergic signals derived from vagus nerve stimulation inhibit the release of TNF, IL-1, HMGB1, and other cytokines by transducing a cellular signal that inhibits the nuclear activity of NF-κB. TNFR, TNF receptor. Modified with permission from Nature Medicine ().
Publication
Physiology and immunology of the cholinergic antiinflammatory pathway. (2007) Kevin J. Tracey. J Clin Invest. 2007 Feb 1;117(2):289-296. Figure: F3.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | TNF | TNF | ncbigene_symbol | TNF | 7124 |
| Homo sapiens | Primates | LPS | LPS | ncbigene_synonym | IRF6 | 3664 |
| Homo sapiens | Primates | TNFR | TNFR | ncbigene_synonym | TNFRSF1A | 7132 |
| Homo sapiens | Primates | TLR4 | TLR4 | ncbigene_symbol | TLR4 | 7099 |
| Homo sapiens | Primates | NACHR | NACHR | ncbigene_synonym | CHRNA4 | 1137 |
| Homo sapiens | Primates | CD14 | CD14 | ncbigene_symbol | CD14 | 929 |
| Homo sapiens | Primates | CD14 | CD14 | ncbigene_synonym | NDUFA2 | 4695 |
| Homo sapiens | Primates | NF-KB | NF-KB | ncbigene_synonym | NFKB1 | 4790 |
| Homo sapiens | Primates | HMGB1- | HMGB1 | ncbigene_symbol | HMGB1 | 3146 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|