Proximal B-cell receptor-mediated signalling pathways
Proximal B-cell receptor-mediated signalling pathways. After binding to antigen, the immunoglobulin (Ig)α and Igβ cytoplasmic tails are phosphorylated on the immunoreceptor tyrosine-based activation motif (ITAM) tyrosines by Src-family tyrosine kinases (SFTKs) and/or Syk. Syk then binds to the Igα ITAM, and the B-cell linker protein (BLNK) binds to tyrosine 204 of Igα. This activates multiple signalling pathways, including: Btk, which activates phospholipase C (PLC)γ2 and leads to calcium flux (blue) and protein kinase C (PKC) activation (green); Grb2, which activates the Ras/Raf/mitogen-activated protein kinase (MEK) extracellular signal-regulated kinase (ERK) pathway (green); and Vav, which activates the Rac/Rho/Cdc42 pathway and results both in cytoskeletal rearrangement (maroon) and c-Jun N-terminal protein kinase (JNK) activation (green). The SFTKs themselves activate nuclear factor-κB (NF-κB) (green).
Publication
B-cell antigen-receptor signalling in lymphocyte development. (2003) Leo D Wang, et al. Immunology. 2003 Dec;110(4):411-420. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | ERK | ERK | ncbigene_synonym | EPHB2 | 2048 |
| Homo sapiens | Primates | ERK | ERK | ncbigene_synonym | MAPK1 | 5594 |
| Homo sapiens | Primates | ERK | ERK | famplex_relations | MAPK3 | 5595 |
| Homo sapiens | Primates | lyn | LYN | ncbigene_symbol | LYN | 4067 |
| Homo sapiens | Primates | fyn | FYN | ncbigene_symbol | FYN | 2534 |
| Homo sapiens | Primates | PLCY | PLCG | famplex_relations | PLCG1 | 5335 |
| Homo sapiens | Primates | PLCY | PLCG | famplex_relations | PLCG2 | 5336 |
| Homo sapiens | Primates | blk | BLK | ncbigene_symbol | BLK | 640 |
| Homo sapiens | Primates | blk | BIK | ncbigene_symbol | BIK | 638 |
| Homo sapiens | Primates | BLNK | BLNK | ncbigene_symbol | BLNK | 29760 |
| Homo sapiens | Primates | Btk | BTK | ncbigene_symbol | BTK | 695 |
| Homo sapiens | Primates | Vav | VAV | ncbigene_synonym | VAV1 | 7409 |
| Homo sapiens | Primates | Vav | VAV | famplex_relations | VAV2 | 7410 |
| Homo sapiens | Primates | Vav | VAV | famplex_relations | VAV3 | 10451 |
| Homo sapiens | Primates | PKC | PKC | ncbigene_synonym | PRRT2 | 112476 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCA | 5578 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCB | 5579 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCD | 5580 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCE | 5581 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCG | 5582 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCH | 5583 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCI | 5584 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCQ | 5588 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCZ | 5590 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKD3 | 23683 |
| Homo sapiens | Primates | NF-KB | NF-KB | ncbigene_synonym | NFKB1 | 4790 |
| Homo sapiens | Primates | JNK | JNK | ncbigene_synonym | MAPK8 | 5599 |
| Homo sapiens | Primates | JNK | JNK | famplex_relations | MAPK9 | 5601 |
| Homo sapiens | Primates | JNK | JNK | famplex_relations | MAPK10 | 5602 |
| Homo sapiens | Primates | LAB | LAB | ncbigene_synonym | LAT2 | 7462 |
| Homo sapiens | Primates | Grb2 | GRB2 | ncbigene_symbol | GRB2 | 2885 |
| Homo sapiens | Primates | Syk | SYK | ncbigene_symbol | SYK | 6850 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| Cancer | NA |