IL-10, IL-22 and IL-22 receptor signalling

IL-10, IL-22 and IL-22 receptor signalling. Binding of IL-10, IL-22 and IL-26 to their respective receptor complex results in the initiation of various signalling cascades. In all cases the JAK/STAT pathway is the primary pathway known to be activated by ligand binding. IL-10 also activates the PI-3K pathway via the binding of the IRS-2 adaptor molecule to the IL-10R complex. STAT-1 and SHP-1 have also been shown to be activated by IL-10, however, the former is only induced with IFN-γ; preincubation. IL-22 and IL-26, like IL-10, initiate the dimerization of STAT-3, however, IL-22 also activates the JNK, ERK and MAPK pathways as well as STAT1 and -5. IL-22 and -26 also activate the acute phase/pro-inflammatory responses in cells rather than de-activation of the inflammatory response.

Publication

Interleukin-10 suppression of myeloid cell activation — a continuing puzzle. (2004) Lynn M Williams, et al. Immunology. 2004 Nov;113(3):281-292. Figure: F3. All organisms Danio rerio Homo sapiens

Disease mentions