Recent observations on the regulation of fetal metabolism by glucose

Insulin, and to a lesser extent the IGFs, activate protein synthesis via a PI3 kinase → Akt → mTOR → p70S6k → 4EBP-1 → eIF4E signal transduction pathway, which can be inhibited at certain points by reduced molecular oxygen supply.
Recent observations on the regulation of fetal metabolism by glucose
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Publication

Recent observations on the regulation of fetal metabolism by glucose. (2006) William W Hay. J Physiol. 2006 Apr 1;572(Pt 1):17-24. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates p85 P85 ncbigene_synonym Myb 32543
Drosophila melanogaster Invertebrates p85 P85 ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates p85 P85 ncbigene_synonym Taf5 47900
Drosophila melanogaster Invertebrates Rs-1.2 RS12 ncbigene_synonym RpS12 39480
Drosophila melanogaster Invertebrates Akt-1,2PI3Kinase AKT-1 ncbigene_synonym Akt 41957
Drosophila melanogaster Invertebrates PI PI ncbigene_symbol pi 5656965
Drosophila melanogaster Invertebrates TSC2 TSC2 ncbigene_synonym gig 40201
Drosophila melanogaster Invertebrates TSC1 TSC1 ncbigene_symbol Tsc1 42862
Drosophila melanogaster Invertebrates GCN2 GCN2 ncbigene_symbol Gcn2 43709
Drosophila melanogaster Invertebrates PERK) PERK ncbigene_synonym PEK 40653
Drosophila melanogaster Invertebrates PERK) PERK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates AMPK AMPK ncbigene_synonym SNF4Agamma 42515
Drosophila melanogaster Invertebrates AMPK AMPK ncbigene_synonym AMPKalpha 43904
Drosophila melanogaster Invertebrates Rheb RHEB ncbigene_symbol Rheb 117332
Drosophila melanogaster Invertebrates ATP ATP ncbigene_synonym ATPsynbeta 43829
Drosophila melanogaster Invertebrates ATP ATP ncbigene_synonym Atpalpha 48971
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym wrd 42169
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym wdb 43312
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym mts 45959
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym tws 47877
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym Pp2A-29B 2768940
Drosophila melanogaster Invertebrates Raptor RAPTOR ncbigene_symbol raptor 31543
Drosophila melanogaster Invertebrates AA AA ncbigene_symbol aa 44792
Drosophila melanogaster Invertebrates P70S6K P70S6K ncbigene_synonym S6k 38654
Drosophila melanogaster Invertebrates P70 P70 ncbigene_synonym WDR79 33865
Drosophila melanogaster Invertebrates P70 P70 ncbigene_synonym tral 39430
Drosophila melanogaster Invertebrates P70 P70 ncbigene_synonym rump 41138
Drosophila melanogaster Invertebrates P70 P70 ncbigene_synonym MED17 42175
Drosophila melanogaster Invertebrates P70 P70 ncbigene_synonym SF1 43912
Drosophila melanogaster Invertebrates P70 P70 ncbigene_synonym Irbp 117419
Drosophila melanogaster Invertebrates 4E-BP1 4E-BP1 ncbigene_synonym Thor 33569
Drosophila melanogaster Invertebrates elF4E ELF4E ncbigene_synonym eIF4E1 45525
Drosophila melanogaster Invertebrates elF4E EIF4E ncbigene_synonym eIF4E7 31059
Drosophila melanogaster Invertebrates elF4E EIF4E ncbigene_synonym eIF4E4 38743
Drosophila melanogaster Invertebrates elF4E EIF4E ncbigene_synonym eIF4E5 38878
Drosophila melanogaster Invertebrates elF4E EIF4E ncbigene_synonym eIF4E3 38923
Drosophila melanogaster Invertebrates elF4E EIF4E ncbigene_synonym eIF4E6 43422
Drosophila melanogaster Invertebrates elF4E EIF4E ncbigene_synonym eIF4EHP 326255
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations ANGPT1 284
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations ANGPT2 285
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations ANGPT4 51378
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations AREG 374
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations BDNF 627
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations CSF1 1435
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EFNA1 1942
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EFNA2 1943
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EFNA3 1944
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EFNA4 1945
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EFNA5 1946
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EGF 1950
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EREG 2069
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF1 2246
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF10 2255
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF16 8823
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF17 8822
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF18 8817
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF19 9965
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF2 2247
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF20 26281
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF21 26291
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF22 27006
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF23 8074
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF3 2248
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF4 2249
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF5 2250
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF6 2251
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF7 2252
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF8 2253
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF9 2254
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FLT3LG 2323
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations HGF 3082
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations IGF1 3479
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations IGF2 3481
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations INS 3630
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations KITLG 4254
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations NGF 4803
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations NTF3 4908
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations NTF4 4909
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations PDGFA 5154
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations PDGFB 5155
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations PDGFC 56034
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations PDGFD 80310
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations PGF 5228
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations TGFA 7039
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations VEGFA 7422
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations VEGFB 7423
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations VEGFC 7424
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations VEGFD 2277
Homo sapiens Primates p85 P85 ncbigene_synonym PIK3R1 5295
Homo sapiens Primates p85 P85 ncbigene_synonym PIK3R2 5296
Homo sapiens Primates p85 P85 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates p85 P85 ncbigene_synonym CBFA2T2 9139
Homo sapiens Primates p85 P85 ncbigene_synonym PPP1R13B 23368
Homo sapiens Primates p85 P85 ncbigene_synonym PPP1R12C 54776
Homo sapiens Primates Akt-1,2PI3Kinase AKT1 ncbigene_symbol AKT1 207
Homo sapiens Primates Akt-1,2 AKT2 ncbigene_symbol AKT2 208
Homo sapiens Primates TSC2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates TSC1 TSC1 ncbigene_symbol TSC1 7248
Homo sapiens Primates TSC1 TSC1 ncbigene_synonym CCL26 10344
Homo sapiens Primates GCN2 GCN2 ncbigene_synonym EIF2AK4 440275
Homo sapiens Primates PERK) PERK ncbigene_synonym EIF2AK3 9451
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Homo sapiens Primates Rheb RHEB ncbigene_symbol RHEB 6009
Homo sapiens Primates Rheb RHEB ncbigene_synonym RHEBP1 6008
Homo sapiens Primates ATP ATP ncbigene_synonym ATP8A2 51761
Homo sapiens Primates PP2A PP2A ncbigene_synonym PTPA 5524
Homo sapiens Primates P70S6K P70S6K ncbigene_synonym RPS6KB1 6198
Homo sapiens Primates P70S6K P70S6K famplex_relations RPS6KB2 6199
Homo sapiens Primates P70 P70 ncbigene_synonym ANXA6 309
Homo sapiens Primates P70 P70 ncbigene_synonym UBASH3B 84959
Homo sapiens Primates 4E-BP1 4E-BP1 ncbigene_synonym EIF4EBP1 1978
Homo sapiens Primates elF4E EIF4E ncbigene_symbol EIF4E 1977
Homo sapiens Primates elF4E EIF4E famplex_relations EIF4E2 9470
Homo sapiens Primates elF4E EIF4E famplex_relations EIF4E3 317649
Homo sapiens Primates GTP GTP ncbigene_synonym MTG1 92170

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID