The inflammatory, coagulation, and fibrinolytic pathways are linked at many levels, leading to organ failure and eventually death
(A) The inflammatory, coagulation, and fibrinolytic pathways are linked at many levels, leading to organ failure and eventually death. (B) The coagulation and fibrinolytic pathways rely on the function of endothelial proteins and protein complexes. Dysfunctional regulatory mechanisms in meningococcal disease include endothelial (protein C pathway) and plasma (TFPI, antithrombin, PAI) factors.

Publication
Pathophysiology of meningococcal meningitis and septicaemia. (2003) N Pathan, et al. Arch Dis Child. 2003 Jul;88(7):601-607. Figure: F2.Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
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Homo sapiens | Primates | TFPI | TFPI | ncbigene_symbol | TFPI | 7035 |
Homo sapiens | Primates | PAI | PAI | ncbigene_synonym | SERPINE1 | 5054 |
Homo sapiens | Primates | PAI | PAI | ncbigene_synonym | SERPINB2 | 5055 |
Homo sapiens | Primates | PC, | PC | ncbigene_symbol | PC | 5091 |
Homo sapiens | Primates | Plasmin | PLG | ncbigene_symbol | PLG | 5340 |
Homo sapiens | Primates | APC | APC | ncbigene_symbol | APC | 324 |
Homo sapiens | Primates | APC | APC | ncbigene_synonym | PROC | 5624 |
Homo sapiens | Primates | tPA | TPA | ncbigene_synonym | HADHA | 3030 |
Homo sapiens | Primates | tPA | TPA | ncbigene_synonym | PLAT | 5327 |
Homo sapiens | Primates | CS,HS,DS | CS | ncbigene_symbol | CS | 1431 |
Homo sapiens | Primates | TM,EPCR | EPCR | ncbigene_synonym | PROCR | 10544 |
Drosophila melanogaster | Invertebrates | PS | PS | ncbigene_symbol | ps | 44258 |
Drosophila melanogaster | Invertebrates | PC, | PC | ncbigene_symbol | Pc | 40358 |
Drosophila melanogaster | Invertebrates | APC | APC | ncbigene_symbol | Apc | 44642 |
Drosophila melanogaster | Invertebrates | APC | APC | ncbigene_synonym | Apc2 | 42871 |
Drosophila melanogaster | Invertebrates | APC | APC | ncbigene_synonym | Axn | 43565 |
Drosophila melanogaster | Invertebrates | APC | APC | ncbigene_synonym | Fs(3)Apc | 49116 |
Drosophila melanogaster | Invertebrates | DS | DS | ncbigene_symbol | ds | 33245 |
Drosophila melanogaster | Invertebrates | CS,HS,DS | CS | ncbigene_symbol | cs | 248200 |
Word | Match | MeSH | Name | ChEBI |
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Disease mentions
Word | Match | MeSH | Name | DOID |
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