The inflammatory, coagulation, and fibrinolytic pathways are linked at many levels, leading to organ failure and eventually death

(A) The inflammatory, coagulation, and fibrinolytic pathways are linked at many levels, leading to organ failure and eventually death. (B) The coagulation and fibrinolytic pathways rely on the function of endothelial proteins and protein complexes. Dysfunctional regulatory mechanisms in meningococcal disease include endothelial (protein C pathway) and plasma (TFPI, antithrombin, PAI) factors.
The inflammatory, coagulation, and fibrinolytic pathways are linked at many levels, leading to organ failure and eventually death

Publication

Pathophysiology of meningococcal meningitis and septicaemia. (2003) N Pathan, et al. Arch Dis Child. 2003 Jul;88(7):601-607. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates TFPI TFPI ncbigene_symbol TFPI 7035
Homo sapiens Primates PAI PAI ncbigene_synonym SERPINE1 5054
Homo sapiens Primates PAI PAI ncbigene_synonym SERPINB2 5055
Homo sapiens Primates PC, PC ncbigene_symbol PC 5091
Homo sapiens Primates Plasmin PLG ncbigene_symbol PLG 5340
Homo sapiens Primates APC APC ncbigene_symbol APC 324
Homo sapiens Primates APC APC ncbigene_synonym PROC 5624
Homo sapiens Primates tPA TPA ncbigene_synonym HADHA 3030
Homo sapiens Primates tPA TPA ncbigene_synonym PLAT 5327
Homo sapiens Primates CS,HS,DS CS ncbigene_symbol CS 1431
Homo sapiens Primates TM,EPCR EPCR ncbigene_synonym PROCR 10544
Drosophila melanogaster Invertebrates PS PS ncbigene_symbol ps 44258
Drosophila melanogaster Invertebrates PC, PC ncbigene_symbol Pc 40358
Drosophila melanogaster Invertebrates APC APC ncbigene_symbol Apc 44642
Drosophila melanogaster Invertebrates APC APC ncbigene_synonym Apc2 42871
Drosophila melanogaster Invertebrates APC APC ncbigene_synonym Axn 43565
Drosophila melanogaster Invertebrates APC APC ncbigene_synonym Fs(3)Apc 49116
Drosophila melanogaster Invertebrates DS DS ncbigene_symbol ds 33245
Drosophila melanogaster Invertebrates CS,HS,DS CS ncbigene_symbol cs 248200

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID