The role of Hsl7p during filamentous growth

Model for the role of Hsl7p during filamentous growth. Hsl7p binds to Ste20p to repress its activity. In response to nitrogen starvation, Ras2p activates Cdc42p and activated Cdc42p interferes with binding of Hsl7p to Ste20p. Two 14–3-3 proteins, Bmh1p and Bmh2p, which are essential for the pathway leading to pseudohyphal growth, also interact with the C terminus of Ste20p ().
The role of Hsl7p during filamentous growth
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Publication

Hsl7p, a negative regulator of Ste20p protein kinase in the Saccharomyces cerevisiae filamentous growth-signaling pathway. (1999) Atsushi Fujita, et al. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8522-8527. Figure: F6.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Saccharomyces cerevisiae S288C Plants and Fungi Ras2 RAS2 ncbigene_symbol RAS2 855625
Saccharomyces cerevisiae S288C Plants and Fungi Bmh2 BMH2 ncbigene_symbol BMH2 851676
Saccharomyces cerevisiae S288C Plants and Fungi Cdc42 CDC42 ncbigene_symbol CDC42 850930
Saccharomyces cerevisiae S288C Plants and Fungi Hsl7 HSL7 ncbigene_symbol HSL7 852431
Saccharomyces cerevisiae S288C Plants and Fungi Bmh1 BMH1 ncbigene_symbol BMH1 856924
Saccharomyces cerevisiae S288C Plants and Fungi Ste20 STE20 ncbigene_symbol STE20 856382
Saccharomyces cerevisiae S288C Plants and Fungi Ste11 STE11 ncbigene_symbol STE11 851076
Saccharomyces cerevisiae S288C Plants and Fungi Ste7 STE7 ncbigene_symbol STE7 851396
Saccharomyces cerevisiae S288C Plants and Fungi Kss1 KSS1 ncbigene_symbol KSS1 852931
Saccharomyces cerevisiae S288C Plants and Fungi Ste12 STE12 ncbigene_symbol STE12 856484
Saccharomyces cerevisiae S288C Plants and Fungi Tec1 TEC1 ncbigene_symbol TEC1 852377

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID