Schematic representation of the Fas pathway used in the mechanistic model

Schematic representation of the Fas pathway used in the mechanistic model. Molecules in blue are directly involved in Fas signalling; molecules in red are inhibitors of the pathway; intermediate reaction complexes are in black. The triggering molecule, FasL, is shaded in green. The output molecule is shaded in blue. Two green coloured reaction arrows represent transport type reactions. Numbers on the arrow indicate the corresponding reactions in electronic supplementary material.
Schematic representation of the Fas pathway used in the mechanistic model
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Publication

Integrated mechanistic and data-driven modelling for multivariate analysis of signalling pathways. (2006) Fei Hua, et al. J R Soc Interface. 2006 Aug 22;3(9):515-526. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates FasL FASL ncbigene_synonym FASLG 356
Homo sapiens Primates FLIP FLIP ncbigene_synonym CFLAR 8837
Homo sapiens Primates FLIP FLIP ncbigene_synonym FIRRM 55732
Homo sapiens Primates Fas FAS ncbigene_symbol FAS 355
Homo sapiens Primates Fas FAS ncbigene_synonym FASN 2194
Homo sapiens Primates casp8 CASP8 ncbigene_symbol CASP8 841
Homo sapiens Primates Smac SMAC ncbigene_synonym DIABLO 56616
Homo sapiens Primates Casp3 CASP3 ncbigene_symbol CASP3 836
Homo sapiens Primates XIAP XIAP ncbigene_symbol XIAP 331
Homo sapiens Primates Casp6 CASP6 ncbigene_symbol CASP6 839
Homo sapiens Primates act ACT ncbigene_synonym SERPINA3 12
Homo sapiens Primates act ACT ncbigene_synonym ACTG1 71
Homo sapiens Primates act ACT ncbigene_synonym ACTG2 72
Homo sapiens Primates act ACT ncbigene_synonym FHL5 9457
Homo sapiens Primates act ACT ncbigene_synonym ACOT7 11332
Homo sapiens Primates act ACT ncbigene_synonym ACTBL2 345651
Homo sapiens Primates act ACT ncbigene_synonym POTEKP 440915
Homo sapiens Primates act ACT ncbigene_synonym POTEM 641455
Homo sapiens Primates Casp CASP ncbigene_synonym CUX1 1523
Homo sapiens Primates Casp CASP ncbigene_synonym CYTIP 9595
Homo sapiens Primates Casp CASP ncbigene_synonym CRTAP 10491

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID