Schematic representation of the ergosterol biosynthetic pathway in C
Schematic representation of the ergosterol biosynthetic pathway in C. albicans. Blocking of the functions of ERG11 and ERG3 results in the accumulation of the boxed metabolites. A detailed description of this pathway is also given by Parks et al. ().
Publication
Candida albicans Mutations in the Ergosterol Biosynthetic Pathway and Resistance to Several Antifungal Agents. (2003) Dominique Sanglard, et al. Antimicrob Agents Chemother. 2003 Aug;47(8):2404-2412. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Saccharomyces cerevisiae S288C | Plants and Fungi | erg11 | ERG11 | ncbigene_symbol | ERG11 | 856398 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | (ERG7) | ERG7 | ncbigene_symbol | ERG7 | 856470 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | ERG6 | ERG6 | ncbigene_symbol | ERG6 | 855003 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | ERG27 | ERG27 | ncbigene_symbol | ERG27 | 850790 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | ERG26, | ERG26 | ncbigene_symbol | ERG26 | 852883 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | ERG25, | ERG25 | ncbigene_symbol | ERG25 | 852951 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | (ERG24) | ERG24 | ncbigene_symbol | ERG24 | 855441 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | erg3 | ERG3 | ncbigene_symbol | ERG3 | 850745 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | (ERG2) | ERG2 | ncbigene_symbol | ERG2 | 855242 |
| Saccharomyces cerevisiae S288C | Plants and Fungi | (ERG4) | ERG4 | ncbigene_symbol | ERG4 | 852872 |
| Homo sapiens | Primates | ERG25, | ERG25 | ncbigene_synonym | MSMO1 | 6307 |
| Homo sapiens | Primates | erg3 | ERG3 | ncbigene_synonym | ERG | 2078 |
| Homo sapiens | Primates | erg3 | ERG3 | ncbigene_synonym | SC5D | 6309 |
| Homo sapiens | Primates | erg3 | ERG3 | ncbigene_synonym | KCNH7 | 90134 |
| Homo sapiens | Primates | (ERG2) | ERG2 | ncbigene_synonym | KCNH6 | 81033 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Eburicol | eburicol | mesh:C014520 | ebericol | chebi:70315 |
| 4,14,dimethyl zymosterol | NA | mesh:C015582 | ||
| 4,4-dimethyl zymosterol | NA | mesh:C015582 | ||
| Zymosterol | NA | mesh:C015582 | ||
| 14-methyl fecosterol | fecosterol | mesh:C039241 | fecosterol | chebi:17038 |
| Fecosterol | fecosterol | mesh:C039241 | fecosterol | chebi:17038 |
| Episterol | episterol | mesh:C060242 | episterol | chebi:23929 |
| Ergosterol | Ergosterol | mesh:D004875 | ergosterol | chebi:16933 |
| Lanosterol | Lanosterol | mesh:D007810 | lanosterol | chebi:16521 |
| Squalene | Squalene | mesh:D013185 | squalene | chebi:15440 |
| oxido-squalene | Squalene | mesh:D013185 | squalene | chebi:15440 |
| C-24 Sterol methyl | Sterols | mesh:D013261 | sterol | chebi:15889 |
| C-3 Sterol | Sterols | mesh:D013261 | sterol | chebi:15889 |
| C-4 Sterol | Sterols | mesh:D013261 | sterol | chebi:15889 |
| Sterol | Sterols | mesh:D013261 | sterol | chebi:15889 |
| Sterol methyl | Sterols | mesh:D013261 | sterol | chebi:15889 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|