Schematic presentation of the GABA shunt metabolic pathway

Schematic presentation of the GABA shunt metabolic pathway. The GABA shunt is composed of three enzymes (depicted in boldface type): glutamate decarboxylase (GAD; EC 4.1.1.15), GABA transaminase (GABA-T; EC 2.6.1.19), and succinic-semialdehyde dehydrogenase (SSADH; EC 1.2.1.16). TCA cycle, tricarboxylic acid cycle; SSA, succinic semialdehyde; SCS, succinyl-CoA synthetase; α-KGDH, α-ketoglutarate dehydrogenase; dashed lines, effectors; solid lines, substrates and products.
Schematic presentation of the GABA shunt metabolic pathway
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Publication

Mitochondrial succinic-semialdehyde dehydrogenase of the γ-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants. (2003) Nicolas Bouché, et al. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6843-6848. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym CycE 34924
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym cyc 40162
Drosophila melanogaster Invertebrates ATP ATP ncbigene_synonym ATPsynbeta 43829
Drosophila melanogaster Invertebrates ATP ATP ncbigene_synonym Atpalpha 48971
Drosophila melanogaster Invertebrates SSADH SSADH ncbigene_symbol Ssadh 43092
Drosophila melanogaster Invertebrates SSA SSA ncbigene_synonym ss 41988
Drosophila melanogaster Invertebrates GABA-T GABAT ncbigene_symbol Gabat 40188
Drosophila melanogaster Invertebrates GAD GAD ncbigene_synonym Gad1 38484
Drosophila melanogaster Invertebrates GABA GABA ncbigene_synonym GABA-B-R1 34878
Drosophila melanogaster Invertebrates GABA GABA ncbigene_synonym Rdl 39054
Homo sapiens Primates ATP ATP ncbigene_synonym ATP8A2 51761
Homo sapiens Primates a-KGDH AKGDH ncbigene_synonym OGDH 4967
Homo sapiens Primates SCS SCS ncbigene_synonym TWIST1 7291
Homo sapiens Primates SSADH SSADH ncbigene_synonym ALDH5A1 7915
Homo sapiens Primates SSA SSA ncbigene_synonym CALR 811
Homo sapiens Primates SSA SSA ncbigene_synonym TRIM21 6737
Homo sapiens Primates GABA-T GABAT ncbigene_synonym ABAT 18
Homo sapiens Primates GAD GAD ncbigene_synonym GAD1 2571
Homo sapiens Primates GAD GAD famplex_relations GAD2 2572

Chemical mentions

Word Match MeSH Name ChEBI
GABA gamma-Aminobutyric Acid mesh:D005680 gamma-aminobutyric acid chebi:16865
Succinate Succinates mesh:D013386 succinate chebi:26806
Glutamate NA mesh:D018698

Disease mentions

Word Match MeSH Name DOID