Erk- and PI3K-Akt-dependent cascades regulating mTOR signaling

Erk- and PI3K-Akt-dependent cascades regulating mTOR signaling. A: In normal condition, activation of either pathway results in the phosphorylation of both p90 ribosomal S6 kinase 1 (RSK1) and Akt that, in turn, are capable of phosphorylating tuberin directly. This inhibits tuberin function and promotes mTOR-mediated signaling. B: In TSC2 cells, the loss of tuberin releases the regulation of mTOR and, likely, may lead to the modification of ERK-RSK1 function with direct/indirect regulation of mTOR. This may explain the EGF requirement for A+ cell proliferation.

Publication

Isolation and Growth of Smooth Muscle-Like Cells Derived from Tuberous Sclerosis Complex-2 Human Renal Angiomyolipoma . (2005) Elena Lesma, et al. Am J Pathol. 2005 Oct;167(4):1093-1103. Figure: F9. All organisms Homo sapiens Drosophila melanogaster Danio rerio

Disease mentions