Phosphatidylinositide 3′-OH kinase/Akt/mTOR signaling pathway

The phosphatidylinositide 3′-OH kinase/Akt/mTOR signaling pathway. The activities of both the raptor (mTORC1) and rictor (mTORC2) complexes are shown.
Phosphatidylinositide 3′-OH kinase/Akt/mTOR signaling pathway
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Publication

Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes. (2006) Sagar B. Kudchodkar, et al. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14182-14187. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates PDK1 PDK1 ncbigene_symbol Pdk1 38017
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates TSC TSC ncbigene_symbol Tsc 247509
Drosophila melanogaster Invertebrates TSC TSC ncbigene_synonym Tsc1 42862
Drosophila melanogaster Invertebrates Rictor RICTOR ncbigene_symbol rictor 32919
Drosophila melanogaster Invertebrates (GBL GBL ncbigene_synonym Lst8 31903
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates Rheb RHEB ncbigene_symbol Rheb 117332
Drosophila melanogaster Invertebrates Raptor RAPTOR ncbigene_symbol raptor 31543
Drosophila melanogaster Invertebrates MTORC1 MTORC1 ncbigene_synonym Crtc 39970
Drosophila melanogaster Invertebrates 4E-BP 4E-BP ncbigene_synonym Thor 33569
Drosophila melanogaster Invertebrates S6K S6K ncbigene_symbol S6k 38654
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E7 31059
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E4 38743
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E5 38878
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E3 38923
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E6 43422
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E1 45525
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4EHP 326255
Drosophila melanogaster Invertebrates EIF4G EIF4G ncbigene_synonym eIF4G2 42819
Drosophila melanogaster Invertebrates EIF4G EIF4G ncbigene_synonym eIF4G1 43839
Drosophila melanogaster Invertebrates elF4A ELF4A ncbigene_synonym CG9932 34701
Drosophila melanogaster Invertebrates elF4A EIF4A ncbigene_symbol eIF4A 33835
Drosophila melanogaster Invertebrates elF4A EIF4A ncbigene_synonym CG7483 40987
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates PDK1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates MTORC2 MTORC2 famplex_relations MAPKAP1 79109
Homo sapiens Primates MTORC2 MTORC2 famplex_relations MTOR 2475
Homo sapiens Primates MTORC2 MTORC2 famplex_relations RICTOR 253260
Homo sapiens Primates MTORC2 MTORC2 famplex_relations MLST8 64223
Homo sapiens Primates TSC TSC ncbigene_synonym SLC12A3 6559
Homo sapiens Primates TSC TSC ncbigene_synonym TSC1 7248
Homo sapiens Primates TSC TSC ncbigene_synonym TESC 54997
Homo sapiens Primates TSC TSC famplex_relations TSC2 7249
Homo sapiens Primates Rheb RHEB ncbigene_symbol RHEB 6009
Homo sapiens Primates Rheb RHEB ncbigene_synonym RHEBP1 6008
Homo sapiens Primates GTP GTP ncbigene_synonym MTG1 92170
Homo sapiens Primates MTORC1 MTORC1 famplex_relations RPTOR 57521
Homo sapiens Primates S6K S6K ncbigene_synonym RPS6KB1 6198
Homo sapiens Primates Mnk1 MNK1 ncbigene_synonym MKNK1 8569
Homo sapiens Primates EIF4E EIF4E ncbigene_symbol EIF4E 1977
Homo sapiens Primates EIF4E EIF4E famplex_relations EIF4E2 9470
Homo sapiens Primates EIF4E EIF4E famplex_relations EIF4E3 317649
Homo sapiens Primates EIF4G EIF4G ncbigene_synonym EIF4G1 1981
Homo sapiens Primates EIF4G EIF4G famplex_relations EIF4G2 1982
Homo sapiens Primates EIF4G EIF4G famplex_relations EIF4G3 8672
Homo sapiens Primates elF4F EIF4F ncbigene_synonym EIF4A2 1974
Homo sapiens Primates elF4A EIF4A ncbigene_synonym EIF4A1 1973
Homo sapiens Primates elF4A EIF4A famplex_relations EIF4A3 9775

Chemical mentions

Word Match MeSH Name ChEBI
Rapamycin Sirolimus mesh:D020123 sirolimus chebi:9168

Disease mentions

Word Match MeSH Name DOID