Cross-talk between the NFKB and the STAT3 pathways

Proposed mechanism of cross-talk between the NFκB and the STAT3 pathways. Constitutive activation of NFκB leads to the production and secretion of cytokines such as IL-6, which acts on the gp130 cytokine receptor family in an autocrine/paracrine manner and causes the consequent activation of STAT3 in an EGFR-independent fashion. Inhibition of NFκB by IκB S32/36A diminishes the secretion of those molecules, thereby blocking the activation of the STA T3 pathway.
Cross-talk between the NFKB and the STAT3 pathways
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Publication

Molecular Cross-Talk between the NFκB and STAT3 Signaling Pathways in Head and Neck Squamous Cell Carcinoma. (2006) Cristiane H Squarize, et al. Neoplasia. 2006 Sep;8(9):733-746. Figure: F9.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates IL6 IL6 ncbigene_symbol IL6 3569
Homo sapiens Primates gp130 GP130 ncbigene_synonym IL6ST 3572
Homo sapiens Primates gp130 GP130 ncbigene_synonym NM 4827
Homo sapiens Primates gp130 GP130 ncbigene_synonym LRPPRC 10128
Homo sapiens Primates IL6R IL6R ncbigene_symbol IL6R 3570
Homo sapiens Primates JAK JAK famplex_relations JAK1 3716
Homo sapiens Primates JAK JAK famplex_relations JAK2 3717
Homo sapiens Primates JAK JAK famplex_relations JAK3 3718
Homo sapiens Primates JAK JAK famplex_relations TYK2 7297
Homo sapiens Primates NFKB NFKB ncbigene_synonym NFKB1 4790
Homo sapiens Primates NFKB NFKB famplex_relations RELA 5970
Homo sapiens Primates NFKB NFKB famplex_relations RELB 5971
Homo sapiens Primates NFKB NFKB famplex_relations REL 5966
Homo sapiens Primates NFKB NFKB famplex_relations NFKB2 4791
Homo sapiens Primates STAT3 STAT3 ncbigene_symbol STAT3 6774
Danio rerio Vertebrates IL6 IL6 ncbigene_symbol il6 100885851
Danio rerio Vertebrates gp130 GP130 ncbigene_synonym il6st 100006778
Danio rerio Vertebrates IL6R IL6R ncbigene_symbol il6r 100135755
Danio rerio Vertebrates STAT3 STAT3 ncbigene_symbol stat3 30767

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID