Involvement of MACF1 in the Wnt/Beta-catenin signaling pathway
A model for the involvement of MACF1 in the Wnt/β-catenin signaling pathway. (A) Without Wnt, MACF1 (red) binds to a protein complex containing Axin (purple), APC (yellow), β-catenin (green), and GSK3β (light blue). There is no expression of the TCF (blue) controlled genes due to the degradation of β-catenin after phosphorylation by GSK3β. (B) Wnt activates its receptor frizzled and its coreceptor LRP-5/6. MACF1 is involved in the translocation of the complex containing Axin, β-catenin, and GSK3β but not APC from the cytosol to the cell membrane, where Axin and MACF1 bind to LRP-5/6. Subsequently, GSK3β is inactivated by phosphorylation, Axin is degraded, and β-catenin is released and enters the nucleus, where it can activate the Wnt-responsive genes.
Publication
The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. (2006) Hui-Jye Chen, et al. Genes Dev. 2006 Jul 15;20(14):1933-1945. Figure: F7.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Rattus norvegicus | Rodents | Wnt | WNT | ncbigene_synonym | Wnt2 | 114487 |
| Rattus norvegicus | Rodents | Axin | AXIN | ncbigene_synonym | Axin1 | 79257 |
| Rattus norvegicus | Rodents | cat | CAT | ncbigene_symbol | Cat | 24248 |
| Rattus norvegicus | Rodents | GSK3B | GSK3B | ncbigene_symbol | Gsk3b | 84027 |
| Rattus norvegicus | Rodents | APC | APC | ncbigene_symbol | Apc | 24205 |
| Rattus norvegicus | Rodents | MACF1 | MACF1 | ncbigene_symbol | Macf1 | 362587 |
| Rattus norvegicus | Rodents | LRP-5 | LRP5 | ncbigene_symbol | Lrp5 | 293649 |
| Rattus norvegicus | Rodents | LRP-5/6 | LRP6 | ncbigene_symbol | Lrp6 | 312781 |
| Mus musculus | Rodents | Axin | AXIN | ncbigene_synonym | Axin1 | 12005 |
| Mus musculus | Rodents | cat | CAT | ncbigene_symbol | Cat | 12359 |
| Mus musculus | Rodents | cat | CAT | ncbigene_synonym | cac | 12285 |
| Mus musculus | Rodents | cat | CAT | ncbigene_synonym | Mip | 17339 |
| Mus musculus | Rodents | cat | CAT | ncbigene_synonym | Trpv6 | 64177 |
| Mus musculus | Rodents | cat | CAT | ncbigene_synonym | Glyat | 107146 |
| Mus musculus | Rodents | GSK3B | GSK3B | ncbigene_symbol | Gsk3b | 56637 |
| Mus musculus | Rodents | MACF | MACF | ncbigene_synonym | Macf1 | 11426 |
| Mus musculus | Rodents | APC | APC | ncbigene_symbol | Apc | 11789 |
| Mus musculus | Rodents | LRP-5 | LRP5 | ncbigene_symbol | Lrp5 | 16973 |
| Mus musculus | Rodents | LRP-5/6 | LRP6 | ncbigene_symbol | Lrp6 | 16974 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT1 | 7471 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT2 | 7472 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT2B | 7482 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT3 | 7473 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT3A | 89780 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT4 | 54361 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT6 | 7475 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT7A | 7476 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT7B | 7477 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT8A | 7478 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT8B | 7479 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT9A | 7483 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT9B | 7484 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT10A | 80326 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT10B | 7480 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT11 | 7481 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT16 | 51384 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT5A | 7474 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT5B | 81029 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD1 | 8321 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD10 | 11211 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD2 | 2535 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD3 | 7976 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD4 | 8322 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD5 | 7855 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD6 | 8323 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD7 | 8324 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD8 | 8325 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD9 | 8326 |
| Homo sapiens | Primates | Axin | AXIN | ncbigene_synonym | AXIN1 | 8312 |
| Homo sapiens | Primates | Axin | AXIN | famplex_relations | AXIN2 | 8313 |
| Homo sapiens | Primates | cat | CAT | ncbigene_symbol | CAT | 847 |
| Homo sapiens | Primates | cat | CAT | ncbigene_synonym | CRAT | 1384 |
| Homo sapiens | Primates | cat | CAT | ncbigene_synonym | GLYAT | 10249 |
| Homo sapiens | Primates | GSK3B | GSK3B | ncbigene_symbol | GSK3B | 2932 |
| Homo sapiens | Primates | MACF | MACF | ncbigene_synonym | MACF1 | 23499 |
| Homo sapiens | Primates | APC | APC | ncbigene_symbol | APC | 324 |
| Homo sapiens | Primates | APC | APC | ncbigene_synonym | PROC | 5624 |
| Homo sapiens | Primates | TCF | TCF | ncbigene_synonym | HNF4A | 3172 |
| Homo sapiens | Primates | LRP-5 | LRP-5 | ncbigene_synonym | LRP5 | 4041 |
| Danio rerio | Vertebrates | cat | CAT | ncbigene_symbol | cat | 30068 |
| Danio rerio | Vertebrates | GSK3B | GSK3B | ncbigene_synonym | gsk3ba | 30654 |
| Danio rerio | Vertebrates | APC | APC | ncbigene_symbol | apc | 386762 |
| Danio rerio | Vertebrates | MACF1 | MACF1 | ncbigene_synonym | macf1a | 562190 |
| Danio rerio | Vertebrates | TCF | TCF | ncbigene_synonym | elk4 | 30093 |
| Danio rerio | Vertebrates | LRP-5 | LRP5 | ncbigene_symbol | lrp5 | 568518 |
| Danio rerio | Vertebrates | LRP-5/6 | LRP6 | ncbigene_symbol | lrp6 | 100003877 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|