TGFB signaling pathway

The TGF-β signaling pathway. TGF-βs bind and activate the TGF-β receptor complex, which transmits signal predominantly via activation and nuclear translocation of Smad proteins. However, several Smad-independent signaling pathways are also activated by this receptor complex, and the outcome of Smad signaling can be modified by interaction with other signaling pathways ().
TGFB signaling pathway
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Publication

TGF-β antagonists: Why suppress a tumor suppressor?. (2002) Rosemary J. Akhurst. J Clin Invest. 2002 Jun 15;109(12):1533-1536. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Danio rerio Vertebrates Smad6,Smad7 SMAD6 ncbigene_synonym smad6a 116992
Danio rerio Vertebrates Smad6,Smad7 SMAD7 ncbigene_symbol smad7 326282
Danio rerio Vertebrates (Smad2) SMAD2 ncbigene_symbol smad2 30639
Danio rerio Vertebrates Ras RAS ncbigene_synonym rab1ab 368883
Danio rerio Vertebrates B-catenin. CTNNB1 ncbigene_symbol ctnnb1 30265
Danio rerio Vertebrates Smad4 SMAD4 ncbigene_synonym smad4a 559111
Danio rerio Vertebrates Smad4 SMAD4 ncbigene_synonym smad4b 794669
Danio rerio Vertebrates C-Jun C-JUN ncbigene_synonym jun 335916
Danio rerio Vertebrates Fast FAST ncbigene_synonym foxh1 57930
Homo sapiens Primates TGF-B TGFB ncbigene_synonym TGFB1 7040
Homo sapiens Primates TGF-B TGFB famplex_relations TGFB2 7042
Homo sapiens Primates TGF-B TGFB famplex_relations TGFB3 7043
Homo sapiens Primates II/betaglycan BETAGLYCAN ncbigene_synonym TGFBR3 7049
Homo sapiens Primates Smad SMAD famplex_relations SMAD1 4086
Homo sapiens Primates Smad SMAD famplex_relations SMAD4 4089
Homo sapiens Primates Smad SMAD famplex_relations SMAD5 4090
Homo sapiens Primates Smad SMAD famplex_relations SMAD6 4091
Homo sapiens Primates Smad SMAD famplex_relations SMAD7 4092
Homo sapiens Primates Smad SMAD famplex_relations SMAD9 4093
Homo sapiens Primates Smad SMAD famplex_relations SMAD2 4087
Homo sapiens Primates Smad SMAD famplex_relations SMAD3 4088
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates PP2A PP2A ncbigene_synonym PTPA 5524
Homo sapiens Primates B-catenin. CTNNB1 ncbigene_symbol CTNNB1 1499
Homo sapiens Primates C-Jun C-JUN ncbigene_synonym JUN 3725
Homo sapiens Primates ATF ATF ncbigene_synonym GDNF 2668
Homo sapiens Primates ATF ATF ncbigene_synonym PLAU 5328
Homo sapiens Primates Fast FAST ncbigene_synonym FASTK 10922
Homo sapiens Primates Fast FAST ncbigene_synonym FOXD3-AS1 100996301
Homo sapiens Primates Fast1 FAST1 ncbigene_synonym FOXH1 8928

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID