EDA signaling in hair follicle development

Schematic representation of EDA signaling in hair follicle development. EDA-A1 or EDA-A5 (ref. ) activate the canonical NF-κB pathway via EDAR and p65/p50, which then signal to Wnt and BMP pathways and their antagonists for hair follicle induction, to Shh and its inhibitors for hair follicle growth, and to the alternative NF-κB pathway, involving LTβ and RelB, for hair-type differentiation. +, positive up-regulation; −, negative regulation (suppression).
EDA signaling in hair follicle development
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Publication

Ectodysplasin regulates the lymphotoxin-β pathway for hair differentiation. (2006) Chang-Yi Cui, et al. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9142-9147. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates EDA-A1 EDA-A1 ncbigene_synonym EDA 1896
Homo sapiens Primates EDARADD EDARADD ncbigene_symbol EDARADD 128178
Homo sapiens Primates EDAR EDAR ncbigene_symbol EDAR 10913
Homo sapiens Primates (p65 P65 ncbigene_synonym RELA 5970
Homo sapiens Primates (p65 P65 ncbigene_synonym SYT1 6857
Homo sapiens Primates (p65 P65 ncbigene_synonym GORASP1 64689
Homo sapiens Primates (p65 P65 ncbigene_synonym WNK1 65125
Homo sapiens Primates NF-KBs NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates NF-KBs(p65/p50) P50 ncbigene_synonym CD40 958
Homo sapiens Primates NF-KBs(p65/p50) P50 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates NF-KBs(p65/p50) P50 ncbigene_synonym ASCC1 51008
Homo sapiens Primates NF-KBs(p65/p50) P50 ncbigene_synonym H3P40 115482723
Homo sapiens Primates Wnt WNT famplex_relations WNT1 7471
Homo sapiens Primates Wnt WNT famplex_relations WNT2 7472
Homo sapiens Primates Wnt WNT famplex_relations WNT2B 7482
Homo sapiens Primates Wnt WNT famplex_relations WNT3 7473
Homo sapiens Primates Wnt WNT famplex_relations WNT3A 89780
Homo sapiens Primates Wnt WNT famplex_relations WNT4 54361
Homo sapiens Primates Wnt WNT famplex_relations WNT6 7475
Homo sapiens Primates Wnt WNT famplex_relations WNT7A 7476
Homo sapiens Primates Wnt WNT famplex_relations WNT7B 7477
Homo sapiens Primates Wnt WNT famplex_relations WNT8A 7478
Homo sapiens Primates Wnt WNT famplex_relations WNT8B 7479
Homo sapiens Primates Wnt WNT famplex_relations WNT9A 7483
Homo sapiens Primates Wnt WNT famplex_relations WNT9B 7484
Homo sapiens Primates Wnt WNT famplex_relations WNT10A 80326
Homo sapiens Primates Wnt WNT famplex_relations WNT10B 7480
Homo sapiens Primates Wnt WNT famplex_relations WNT11 7481
Homo sapiens Primates Wnt WNT famplex_relations WNT16 51384
Homo sapiens Primates Wnt WNT famplex_relations WNT5A 7474
Homo sapiens Primates Wnt WNT famplex_relations WNT5B 81029
Homo sapiens Primates Dkk1) DKK1 ncbigene_symbol DKK1 22943
Homo sapiens Primates (Dkk4 DKK4 ncbigene_symbol DKK4 27121
Homo sapiens Primates BMP BMP famplex_relations BMP1 649
Homo sapiens Primates BMP BMP famplex_relations BMP2 650
Homo sapiens Primates BMP BMP famplex_relations BMP3 651
Homo sapiens Primates BMP BMP famplex_relations BMP4 652
Homo sapiens Primates BMP BMP famplex_relations BMP5 653
Homo sapiens Primates BMP BMP famplex_relations BMP6 654
Homo sapiens Primates BMP BMP famplex_relations BMP7 655
Homo sapiens Primates BMP BMP famplex_relations BMP8A 353500
Homo sapiens Primates BMP BMP famplex_relations BMP8B 656
Homo sapiens Primates BMP BMP famplex_relations BMP10 27302
Homo sapiens Primates BMP BMP famplex_relations BMP15 9210
Homo sapiens Primates BMP BMP famplex_relations GDF1 2657
Homo sapiens Primates BMP BMP famplex_relations GDF2 2658
Homo sapiens Primates BMP BMP famplex_relations GDF3 9573
Homo sapiens Primates BMP BMP famplex_relations GDF5 8200
Homo sapiens Primates BMP BMP famplex_relations GDF6 392255
Homo sapiens Primates BMP BMP famplex_relations GDF7 151449
Homo sapiens Primates (Sostdc1) SOSTDC1 ncbigene_symbol SOSTDC1 25928
Homo sapiens Primates Shh SHH ncbigene_symbol SHH 6469
Homo sapiens Primates Ptc PTC ncbigene_synonym F9 2158
Homo sapiens Primates Ptc PTC ncbigene_synonym TAS2R38 5726
Homo sapiens Primates Ptc PTC ncbigene_synonym PTCH1 5727
Homo sapiens Primates Ptc PTC ncbigene_synonym RET 5979
Homo sapiens Primates Ptc PTC ncbigene_synonym CCDC6 8030
Homo sapiens Primates Gli GLI ncbigene_synonym GLI1 2735
Homo sapiens Primates RelB RELB ncbigene_symbol RELB 5971
Homo sapiens Primates LTB LTB ncbigene_symbol LTB 4050
Mus musculus Rodents EDA-A1 EDA-A1 ncbigene_synonym Eda 13607
Mus musculus Rodents EDARADD EDARADD ncbigene_symbol Edaradd 171211
Mus musculus Rodents EDAR EDAR ncbigene_symbol Edar 13608
Mus musculus Rodents (p65 P65 ncbigene_synonym Rela 19697
Mus musculus Rodents (p65 P65 ncbigene_synonym Gorasp1 74498
Mus musculus Rodents NF-KBs NF-KB ncbigene_synonym Nfkb1 18033
Mus musculus Rodents NF-KBs(p65/p50) P50 ncbigene_synonym Cdc37 12539
Mus musculus Rodents NF-KBs(p65/p50) P50 ncbigene_synonym Lsp1 16985
Mus musculus Rodents NF-KBs(p65/p50) P50 ncbigene_synonym Pold2 18972
Mus musculus Rodents NF-KBs(p65/p50) P50 ncbigene_synonym Cd40 21939
Mus musculus Rodents NF-KBs(p65/p50) P50 ncbigene_synonym Dctn2 69654
Mus musculus Rodents Dkk1) DKK1 ncbigene_symbol Dkk1 13380
Mus musculus Rodents (Dkk4 DKK4 ncbigene_symbol Dkk4 234130
Mus musculus Rodents (Sostdc1) SOSTDC1 ncbigene_symbol Sostdc1 66042
Mus musculus Rodents Shh SHH ncbigene_symbol Shh 20423
Mus musculus Rodents Ptc PTC ncbigene_synonym Ptch1 19206
Mus musculus Rodents Ptc PTC ncbigene_synonym Ret 19713
Mus musculus Rodents Gli G2 ncbigene_synonym Gabrg2 14406
Mus musculus Rodents RelB RELB ncbigene_symbol Relb 19698
Mus musculus Rodents LTB LTB ncbigene_symbol Ltb 16994
Danio rerio Vertebrates EDARADD EDARADD ncbigene_symbol edaradd 566761
Danio rerio Vertebrates EDAR EDAR ncbigene_symbol edar 796370
Danio rerio Vertebrates (p65 P65 ncbigene_synonym rela 415099
Danio rerio Vertebrates NF-KBs(p65/p50) P50 ncbigene_synonym nfkb1 565756
Danio rerio Vertebrates Dkk1) DKK1 ncbigene_synonym dkk1b 30197
Danio rerio Vertebrates (Sostdc1) SOSTDC1 ncbigene_synonym sostdc1b 564783
Danio rerio Vertebrates Shh SHH ncbigene_synonym shha 30269
Danio rerio Vertebrates Gli GLI ncbigene_symbol gli 30097
Danio rerio Vertebrates RelB RELB ncbigene_symbol relb 795414

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID