The JNK pathway promotes and maintains mitosis until the mitotic-to-endocycle transition point

The JNK pathway promotes and maintains mitosis until the mitotic-to-endocycle transition point. At the transition, the Notch pathway acts through ttk on the cell cycle components stg, dap, and fzr in follicle cells to stop mitotic cycling and induce endocycling. Notch, which is modulated by Dl, dsh, and sgg, also plays a role in cell differentiation without the involvement of ttk, as shown by its effect on FAS3 expression.
The JNK pathway promotes and maintains mitosis until the mitotic-to-endocycle transition point
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Publication

Notch signaling through Tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells. (2006) Katherine C Jordan, et al. BMC Dev Biol. 2006;6:16-16. Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates -Sgg SGG ncbigene_symbol sgg 31248
Drosophila melanogaster Invertebrates Dsh DSH ncbigene_symbol dsh 32078
Drosophila melanogaster Invertebrates Su(H) SU(H) ncbigene_symbol Su(H) 34881
Drosophila melanogaster Invertebrates Hep HEP ncbigene_symbol hep 32256
Drosophila melanogaster Invertebrates Fas3 FAS3 ncbigene_symbol Fas3 35097
Drosophila melanogaster Invertebrates |Bsk BSK ncbigene_symbol bsk 44801
Drosophila melanogaster Invertebrates Ttk TTK ncbigene_symbol ttk 48317
Drosophila melanogaster Invertebrates Puc PUC ncbigene_symbol puc 40958
Drosophila melanogaster Invertebrates Fzr FZR ncbigene_symbol fzr 45922
Drosophila melanogaster Invertebrates Cdc25 CDC25 ncbigene_synonym twe 34954
Drosophila melanogaster Invertebrates Cdc25 CDC25 ncbigene_synonym stg 43466
Drosophila melanogaster Invertebrates Cdc2 CDC2 ncbigene_synonym Cdk1 34411
Drosophila melanogaster Invertebrates Cdc2 CDC2 ncbigene_synonym fzy 34968
Drosophila melanogaster Invertebrates G2 G2 ncbigene_synonym anon-70Dc 5657482
Drosophila melanogaster Invertebrates G1 G1 ncbigene_synonym LanB2 39118
Drosophila melanogaster Invertebrates G1 G1 ncbigene_synonym anon-70Db 5657481
Drosophila melanogaster Invertebrates P21 P21 ncbigene_synonym dap 36001
Drosophila melanogaster Invertebrates Dap DAP ncbigene_synonym AstA 42947
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym CycE 34924
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym cyc 40162
Mus musculus Rodents DI DI ncbigene_symbol di 13364
Mus musculus Rodents Dsh DSH ncbigene_synonym Shh 20423
Mus musculus Rodents |Bsk BSK ncbigene_synonym Epha5 13839
Mus musculus Rodents |Bsk BSK ncbigene_synonym Frk 14302
Mus musculus Rodents |Bsk BSK ncbigene_synonym Gsdma3 450219
Mus musculus Rodents Ttk TTK ncbigene_symbol Ttk 22137
Mus musculus Rodents Ttk TTK ncbigene_synonym Ttbk2 140810
Mus musculus Rodents Fzr FZR ncbigene_synonym Fzr1 56371
Mus musculus Rodents Cdc25 CDC25 ncbigene_synonym Cdc25c 12532
Mus musculus Rodents Cdc25 CDC25 ncbigene_synonym Rasgrf1 19417
Mus musculus Rodents Stg STG ncbigene_synonym Cacng2 12300
Mus musculus Rodents Stg STG ncbigene_synonym Sgta 52551
Mus musculus Rodents Stg STG ncbigene_synonym 2300002M23Rik 69542
Mus musculus Rodents Cdc2 CDC2 ncbigene_synonym Cdk1 12534
Mus musculus Rodents Cdc2 CDC2 ncbigene_synonym Cdc2b 107833
Mus musculus Rodents G2 G2 ncbigene_synonym Gabrg2 14406
Mus musculus Rodents P21 P21 ncbigene_synonym Cdkn1a 12575
Mus musculus Rodents P21 P21 ncbigene_synonym Nsg1 18196
Mus musculus Rodents P21 P21 ncbigene_synonym Tpt1 22070
Mus musculus Rodents P21 P21 ncbigene_synonym Tceal1 237052
Mus musculus Rodents Dap DAP ncbigene_symbol Dap 223453
Mus musculus Rodents Dap DAP ncbigene_synonym Iapp 15874
Homo sapiens Primates Dsh DSH ncbigene_synonym ADAR 103
Homo sapiens Primates Dsh DSH ncbigene_synonym DVL1P1 8215
Homo sapiens Primates Su(H) SUH ncbigene_synonym RBPJ 3516
Homo sapiens Primates Hep HEP ncbigene_synonym EPHB6 2051
Homo sapiens Primates Hep HEP ncbigene_synonym DNLZ 728489
Homo sapiens Primates Ttk TTK ncbigene_symbol TTK 7272
Homo sapiens Primates Fzr FZR ncbigene_synonym FZR1 51343
Homo sapiens Primates Cdc25 CDC25 ncbigene_synonym CDC25C 995
Homo sapiens Primates Cdc25 CDC25 ncbigene_synonym RASGRF1 5923
Homo sapiens Primates Cdc25 CDC25 famplex_relations CDC25A 993
Homo sapiens Primates Cdc25 CDC25 famplex_relations CDC25B 994
Homo sapiens Primates Stg STG ncbigene_synonym C6orf15 29113
Homo sapiens Primates Cdc2 CDC2 ncbigene_synonym CDK1 983
Homo sapiens Primates Cdc2 CDC2 ncbigene_synonym POLD1 5424
Homo sapiens Primates G2 G2 ncbigene_synonym WARS1 7453
Homo sapiens Primates P21 P21 ncbigene_synonym CDKN1A 1026
Homo sapiens Primates P21 P21 ncbigene_synonym TCEAL1 9338
Homo sapiens Primates P21 P21 ncbigene_synonym NSG1 27065
Homo sapiens Primates P21 P21 ncbigene_synonym H3P16 644914
Homo sapiens Primates Dap DAP ncbigene_symbol DAP 1611
Homo sapiens Primates Dap DAP ncbigene_synonym IAPP 3375
Homo sapiens Primates Dap DAP ncbigene_synonym DNPEP 23549
Rattus norvegicus Rodents Hep HEP ncbigene_synonym Hpse 64537
Rattus norvegicus Rodents Ttk TTK ncbigene_symbol Ttk 315852
Rattus norvegicus Rodents Cdh CDH ncbigene_synonym Chdh 290551
Rattus norvegicus Rodents Stg STG ncbigene_synonym Sgta 64667
Rattus norvegicus Rodents Stg STG ncbigene_synonym RGD1562885 502412
Rattus norvegicus Rodents Cdc2 CDC2 ncbigene_synonym Cdk1 54237
Rattus norvegicus Rodents P21 P21 ncbigene_synonym Kras 24525
Rattus norvegicus Rodents Dap DAP ncbigene_symbol Dap 64322
Rattus norvegicus Rodents cycle CYCLE ncbigene_synonym Ccne1 25729
Arabidopsis thaliana Plants and Fungi Fas3 FAS3 ncbigene_synonym CLV1 843915
Arabidopsis thaliana Plants and Fungi Cdc25 CDC25 ncbigene_symbol CDC25 831832
Arabidopsis thaliana Plants and Fungi Cdc2 CDC2 ncbigene_symbol CDC2 824036
Arabidopsis thaliana Plants and Fungi G1 G1 ncbigene_symbol G1 824342

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID