Impact of SV40 ST on the Notch, Wnt, and Hedgehog Pathways

Impact of SV40 ST on the Notch, Wnt, and Hedgehog Pathways. Schematics of the Notch, Wnt, and Hedgehog pathways are shown. Genes with significantly increased mRNA's in HEK-TERST cells compared to HEK-TERV cells are shown in red, while genes significantly decreased are shown in green. Sets of downstream targets of the Wnt pathway are grouped in boxes, as are sets of c-myc downstream targets. Activation of the Hedgehog pathway due to increased HIP, SMO, and GLI2 levels results in increased Wnt ligand expression. Activation of Wnt signaling increases c-myc, activating and repressing multiple downstream target genes. Wnt pathway activation also feeds back to activate expression of Notch ligands such as DLL1.

Publication

Cross-platform expression profiling demonstrates that SV40 small tumor antigen activates Notch, Hedgehog, and Wnt signaling in human cells. (2006) Mohamed Ali-Seyed, et al. BMC Cancer. 2006;6:54-54. Figure: F5. All organisms Homo sapiens Mus musculus Drosophila melanogaster Danio rerio

Disease mentions