Triple membrane-passing signal mechanism of EGFR transactivation

Triple membrane-passing signal mechanism of EGFR transactivation. GPCR-induced EGFR transactivation involves as key elements pro-HB-EGF, an EGF-like growth factor precursor, and a metalloproteinase activity that is induced upon G-protein activation. Therefore, this new mechanistic concept for ligand-dependent GPCR-EGFR cross-talk entails three membrane-passing signals and couples G-protein signalling to activation of the Ras-MAPK pathway.
Triple membrane-passing signal mechanism of EGFR transactivation
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Publication

Tyrosine kinase signalling in breast cancer: Epidermal growth factor receptor - convergence point for signal integration and diversification. (2000) Norbert Prenzel, et al. Breast Cancer Res. 2000;2(3):184-190. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents HB-EGF HBEGF ncbigene_symbol Hbegf 15200
Mus musculus Rodents EGFR EGFR ncbigene_symbol Egfr 13649
Mus musculus Rodents GPCR GPCR ncbigene_synonym Gpbar1 227289
Mus musculus Rodents SHC SHC ncbigene_synonym Shc1 20416
Mus musculus Rodents Ras/MAP-Kinase RAS ncbigene_symbol ras 19412
Mus musculus Rodents Ras/MAP-Kinase RAS ncbigene_synonym Hras 15461
Mus musculus Rodents Ras/MAP-Kinase RAS ncbigene_synonym Kras 16653
Mus musculus Rodents Ras/MAP-Kinase RAS ncbigene_synonym Rem1 19700
Homo sapiens Primates HB-EGF HBEGF ncbigene_symbol HBEGF 1839
Homo sapiens Primates EGFR EGFR ncbigene_symbol EGFR 1956
Homo sapiens Primates GPCR GPCR ncbigene_synonym FZD4 8322
Homo sapiens Primates GPCR GPCR ncbigene_synonym NMUR1 10316
Homo sapiens Primates GPCR GPCR ncbigene_synonym LPAR3 23566
Homo sapiens Primates GPCR GPCR ncbigene_synonym LGR6 59352
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX3 117195
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX4 117196
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPR151 134391
Homo sapiens Primates GPCR GPCR ncbigene_synonym OXER1 165140
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPRC6A 222545
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX1 259249
Homo sapiens Primates GPCR GPCR ncbigene_synonym VN1R17P 441931
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPR166P 442206
Homo sapiens Primates GPCR GPCR famplex_relations GRM1 2911
Homo sapiens Primates GPCR GPCR famplex_relations GRM2 2912
Homo sapiens Primates GPCR GPCR famplex_relations GRM3 2913
Homo sapiens Primates GPCR GPCR famplex_relations GRM4 2914
Homo sapiens Primates GPCR GPCR famplex_relations GRM5 2915
Homo sapiens Primates GPCR GPCR famplex_relations GRM6 2916
Homo sapiens Primates GPCR GPCR famplex_relations GRM7 2917
Homo sapiens Primates GPCR GPCR famplex_relations GRM8 2918
Homo sapiens Primates GPCR GPCR famplex_relations CASR 846
Homo sapiens Primates GPCR GPCR famplex_relations GABBR1 2550
Homo sapiens Primates GPCR GPCR famplex_relations GABBR2 9568
Homo sapiens Primates GPCR GPCR famplex_relations GPR156 165829
Homo sapiens Primates GPCR GPCR famplex_relations GPR158 57512
Homo sapiens Primates GPCR GPCR famplex_relations GPR179 440435
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5A 9052
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5B 51704
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5C 55890
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5D 55507
Homo sapiens Primates SHC SHC ncbigene_synonym SHC1 6464
Homo sapiens Primates SHC SHC famplex_relations SHC2 25759
Homo sapiens Primates SHC SHC famplex_relations SHC3 53358
Homo sapiens Primates SHC SHC famplex_relations SHC4 399694
Homo sapiens Primates Ras/MAP-Kinase RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras/MAP-Kinase RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras/MAP-Kinase RAS famplex_relations NRAS 4893
Drosophila melanogaster Invertebrates EGFR EGFR ncbigene_symbol Egfr 37455
Drosophila melanogaster Invertebrates GPCR GPCR ncbigene_synonym Oamb 43982
Drosophila melanogaster Invertebrates SHC SHC ncbigene_symbol Shc 44052
Drosophila melanogaster Invertebrates Ras/MAP-Kinase RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates Ras/MAP-Kinase RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates Ras/MAP-Kinase RAS ncbigene_synonym Ras85D 41140

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID