Phosphoinositide 3-kinase (PI3K) signalling and cancer

Phosphoinositide 3-kinase (PI3K) signalling and cancer. Schematic signalling pathway indicating the interactions that occur between known breast cancer oncogenes (ErbB2, Src) and tumour suppressors (PTEN, BRCA1) with components of the PI3K signalling cassette. Direct physical interactions are shown with solid arrows. Processes involving several steps are indicated with a dashed arrow; +, an activation step. Blunt arrows indicate inhibitory effects. Akt, Protein kinase B; ATM, ataxia telangiectasia mutated; ER, oestrogen receptor; 3-Ptase and 5-Ptase, phosphoinositide 3-phosphatase and phosphoinositide 5-phosphatase activities; PTEN, phosphatase and tensin homolog deleted on chromosome 10; TOR, target of rapamycin.
Phosphoinositide 3-kinase (PI3K) signalling and cancer
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play?. (2001) Michael John Fry. Breast Cancer Res. 2001;3(5):304-312. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates BRK BRK ncbigene_symbol brk 31665
Drosophila melanogaster Invertebrates c-Src C-SRC ncbigene_synonym Src64B 48973
Drosophila melanogaster Invertebrates Ras RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates p85 P85 ncbigene_synonym Myb 32543
Drosophila melanogaster Invertebrates p85 P85 ncbigene_synonym Taf5 47900
Drosophila melanogaster Invertebrates -PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates Ptdlns(3,4)P2, 4P2 ncbigene_synonym Cyp4p2 35946
Drosophila melanogaster Invertebrates Ptdlns3P, PTDINS3P ncbigene_synonym fab1 37033
Drosophila melanogaster Invertebrates PDK1 PDK1 ncbigene_symbol Pdk1 38017
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates TOR TOR ncbigene_symbol tor 35717
Drosophila melanogaster Invertebrates TOR TOR ncbigene_symbol Tor 47396
Drosophila melanogaster Invertebrates TOR TOR ncbigene_synonym Egfr 37455
Drosophila melanogaster Invertebrates CyclinD CYCLIND ncbigene_synonym CycD 32551
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym CycE 34924
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym cyc 40162
Drosophila melanogaster Invertebrates ATM ATM ncbigene_synonym tefu 41839
Homo sapiens Primates ErbB ERBB ncbigene_synonym EGFR 1956
Homo sapiens Primates ErbB ERBB famplex_relations ERBB2 2064
Homo sapiens Primates ErbB ERBB famplex_relations ERBB3 2065
Homo sapiens Primates ErbB ERBB famplex_relations ERBB4 2066
Homo sapiens Primates BRK BRK ncbigene_synonym PTK6 5753
Homo sapiens Primates c-Src C-SRC ncbigene_synonym SRC 6714
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates p85 P85 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates p85 P85 ncbigene_synonym CBFA2T2 9139
Homo sapiens Primates p85 P85 ncbigene_synonym PPP1R13B 23368
Homo sapiens Primates p85 P85 ncbigene_synonym PPP1R12C 54776
Homo sapiens Primates -PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates -5-Ptase 5PTASE ncbigene_synonym INPP5A 3632
Homo sapiens Primates -5-Ptase 5PTASE ncbigene_synonym INPP5B 3633
Homo sapiens Primates PDK1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates TOR TOR ncbigene_synonym RORC 6097
Homo sapiens Primates BRCA1 BRCA1 ncbigene_symbol BRCA1 672
Homo sapiens Primates CyclinD CYCLIND famplex_relations CCND1 595
Homo sapiens Primates CyclinD CYCLIND famplex_relations CCND2 894
Homo sapiens Primates CyclinD CYCLIND famplex_relations CCND3 896
Homo sapiens Primates ATM ATM ncbigene_symbol ATM 472

Chemical mentions

Word Match MeSH Name ChEBI
Ly294002 NA mesh:C085911
Rapamycin Sirolimus mesh:D020123 sirolimus chebi:9168

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Lung cancer NA