Association between human TLRs and adaptors determine each TLR-specific signaling pathway

Association between human TLRs and adaptors determine each TLR-specific signaling pathway. Topology of the adaptor proteins in the TIR domains of TLR2, TLR3 and TLR4 is shown in the schema. The complex consisting of each TIR and adaptors delivers TLR signaling to activate NF-κB and the IFN-β promoter (IRF-3). In pDC, activation of TLR7 or 9 happens to activate IRF-7 in a MyD88-dependent way followed by induction of IFN-α. Representative ligands of TLRs are shown on the top.
Association between human TLRs and adaptors determine each TLR-specific signaling pathway
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Publication

Role of Toll-like Receptors in Adjuvant-Augmented Immune Therapies. (2006) Tsukasa Seya, et al. Evid Based Complement Alternat Med. 2006 Mar;3(1):31-38. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates LPS LPS ncbigene_synonym IRF6 3664
Homo sapiens Primates TLR7/9 TLR9 ncbigene_symbol TLR9 54106
Homo sapiens Primates TLR7/9 TLR7 ncbigene_symbol TLR7 51284
Homo sapiens Primates TLR2 TLR2 ncbigene_symbol TLR2 7097
Homo sapiens Primates TLR4 TLR4 ncbigene_symbol TLR4 7099
Homo sapiens Primates TLR3 TLR3 ncbigene_symbol TLR3 7098
Homo sapiens Primates TLR5 TLR5 ncbigene_symbol TLR5 7100
Homo sapiens Primates TICAM-2 TICAM-2 ncbigene_synonym TICAM2 353376
Homo sapiens Primates TICAM-2 TICAM-2 ncbigene_synonym TMED7-TICAM2 100302736
Homo sapiens Primates TICAM-1 TICAM-1 ncbigene_synonym TICAM1 148022
Homo sapiens Primates TIRAP, TIRAP ncbigene_symbol TIRAP 114609
Homo sapiens Primates Mal/TIRAP, MAL ncbigene_symbol MAL 4118
Homo sapiens Primates Mal/TIRAP, MAL ncbigene_synonym MRTFA 57591
Homo sapiens Primates Mal/TIRAP, MA1 ncbigene_synonym PNMA1 9240
Homo sapiens Primates Mal/TIRAP, MAI ncbigene_synonym GSTZ1 2954
Homo sapiens Primates MyD88 MYD88 ncbigene_symbol MYD88 4615
Homo sapiens Primates IRAK IRAK ncbigene_synonym IRAK1 3654
Homo sapiens Primates IRF-7 IRF-7 ncbigene_synonym IRF7 3665
Homo sapiens Primates TRAF6 TRAF6 ncbigene_symbol TRAF6 7189
Homo sapiens Primates IRF-3 IRF3 ncbigene_symbol IRF3 3661
Homo sapiens Primates ATF-2/c-Jun C-JUN ncbigene_synonym JUN 3725
Homo sapiens Primates ATF-2 ATF2 ncbigene_symbol ATF2 1386
Homo sapiens Primates ATF-2 ATF2 ncbigene_synonym GDNF 2668
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates (p38,ERK,JNK) ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates IFN-B IFN-B ncbigene_synonym IFNB1 3456
Homo sapiens Primates IL-6, IL-6 ncbigene_synonym IL6 3569
Homo sapiens Primates TNF-a TNF-A ncbigene_synonym TNF 7124
Homo sapiens Primates IFN-a IFN-A ncbigene_synonym IFNA1 3439
Danio rerio Vertebrates TLR7/9 TLR9 ncbigene_symbol tlr9 403128
Danio rerio Vertebrates TLR7/9 TLR7 ncbigene_symbol tlr7 100534776
Danio rerio Vertebrates TLR2 TLR2 ncbigene_symbol tlr2 403125
Danio rerio Vertebrates TLR3 TLR3 ncbigene_symbol tlr3 403126
Danio rerio Vertebrates TLR5 TLR5 ncbigene_synonym tlr5b 403139
Danio rerio Vertebrates TICAM-1 TICAM1 ncbigene_symbol ticam1 403147
Danio rerio Vertebrates TIRAP, TIRAP ncbigene_symbol tirap 403148
Danio rerio Vertebrates Mal/TIRAP, MAL ncbigene_synonym malb 550381
Danio rerio Vertebrates MyD88 MYD88 ncbigene_symbol myd88 403145
Danio rerio Vertebrates IRF-7 IRF7 ncbigene_symbol irf7 393650
Danio rerio Vertebrates TRAF6 TRAF6 ncbigene_symbol traf6 554561
Danio rerio Vertebrates IRF-3 IRF3 ncbigene_symbol irf3 564854
Danio rerio Vertebrates ATF-2/c-Jun C-JUN ncbigene_synonym jun 335916
Danio rerio Vertebrates ATF-2 ATF2 ncbigene_symbol atf2 100006516
Danio rerio Vertebrates (p38,ERK,JNK) JNK ncbigene_synonym mapk8b 65236
Danio rerio Vertebrates (p38,ERK,JNK) P38 ncbigene_synonym mapk14a 65237
Danio rerio Vertebrates IL-6, IL6 ncbigene_symbol il6 100885851
Danio rerio Vertebrates TNF-a TNF-A ncbigene_synonym tnfb 554167

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID